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Safety and outcomes of routine endovascular thrombectomy in large artery occlusion recorded in the SITS Register: An observational study
N. Ahmed, M. Mazya, AP. Nunes, T. Moreira, JP. Ollikainen, I. Escudero-Martinez, G. Bigliardi, L. Dorado, A. Dávalos, JA. Egido, R. Tassi, D. Strbian, A. Zini, P. Nichelli, R. Herzig, L. Jurák, E. Hurtikova, G. Tsivgoulis, A. Peeters, M....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, pozorovací studie, práce podpořená grantem
NLK
Free Medical Journals
od 1997 do Před 2 roky
Wiley Free Content
od 1997 do Před 2 roky
PubMed
33999451
DOI
10.1111/joim.13302
Knihovny.cz E-zdroje
- MeSH
- arterie MeSH
- cévní mozková příhoda * MeSH
- endovaskulární výkony MeSH
- intrakraniální krvácení MeSH
- ischemie mozku * chirurgie MeSH
- lidé MeSH
- randomizované kontrolované studie jako téma MeSH
- retrospektivní studie MeSH
- trombektomie * MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
BACKGROUND AND OBJECTIVE: We aimed to evaluate the safety and outcomes of thrombectomy in anterior circulation acute ischaemic stroke recorded in the SITS-International Stroke Thrombectomy Register (SITS-ISTR) and compare them with pooled randomized controlled trials (RCTs) and two national registry studies. METHODS: We identified centres recording ≥10 consecutive patients in the SITS-ISTR with at least 70% of available modified Rankin Scale (mRS) at 3 months during 2014-2019. We defined large artery occlusion as intracranial internal carotid artery, first and second segment of middle cerebral artery and first segment of anterior cerebral artery. Outcome measures were functional independence (mRS score 0-2) and death at 3 months and symptomatic intracranial haemorrhage (SICH) per modified SITS-MOST. RESULTS: Results are presented in the following order: SITS-ISTR, RCTs, MR CLEAN Registry and German Stroke Registry (GSR). Median age was 73, 68, 71 and 75 years; baseline NIHSS score was 16, 17, 16 and 15; prior intravenous thrombolysis was 62%, 83%, 78% and 56%; onset to reperfusion time was 289, 285, 267 and 249 min; successful recanalization (mTICI score 2b or 3) was 86%, 71%, 59% and 83%; functional independence at 3 months was 45.5% (95% CI: 44-47), 46.0% (42-50), 38% (35-41) and 37% (35-41), respectively; death was 19.2% (19-21), 15.3% (12.7-18.4), 29.2% (27-32) and 28.6% (27-31); and SICH was 3.6% (3-4), 4.4% (3.0-6.4), 5.8% (4.7-7.1) and not available. CONCLUSION: Thrombectomy in routine clinical use registered in the SITS-ISTR showed safety and outcomes comparable to RCTs, and better functional outcomes and lower mortality than previous national registry studies.
2nd Department of Neurology National and Kapodistrian University of Athens Athens Greece
Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
Department of Human Neurosciences La Sapienza Rome Italy
Department of Neurology Cliniques Universitaires St Luc Brussels Belgium
Department of Neurology Helsinki University Central Hospital Helsinki Finland
Department of Neurology Hospital Clínico San Carlos Madrid Spain
Department of Neurology Hospital Universitari Germans Trias i Pujol Badalona Spain
Department of Neurology Nemocnice Ceske Budejovice Ceske Budejovice Czech Republic
Department of Neurology Ospedale San Giovanni Bosco Turin Italy
Department of Neurology Tampere University Hospital Tampere Finland
Department of Neurology University Hospital Ostrava Ostrava Czech Republic
Department of Neuroradiology Karolinska University Hospital Stockholm Sweden
Faculty of Social Sciences and Health Constantine the Philosopher University Nitra Nitra Slovakia
From the Department of Neurology Karolinska University Hospital Stockholm Sweden
Neurocentre Regional Hospital Liberec Liberec Czech Republic
School of Medicine Nursing and Dentistry University of Glasgow Glasgow UK
Stroke Unit Azienda Ospedaliera Universitaria Senese Siena Italy
Stroke Unit Hospital de São José Centro Hospitalar Universitário de Lisboa Central Lisboa Portugal
Citace poskytuje Crossref.org
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