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Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study
KN. Fountoulakis, E. Dragioti, AT. Theofilidis, T. Wiklund, X. Atmatzidis, I. Nimatoudis, E. Thys, M. Wampers, L. Hranov, T. Hristova, D. Aptalidis, R. Milev, F. Iftene, F. Spaniel, P. Knytl, P. Furstova, T. From, H. Karlsson, M. Walta, RKR....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie
NLK
ProQuest Central
od 2012-06-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2012-06-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2012-06-01 do Před 1 rokem
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- progrese nemoci MeSH
- schizofrenie (psychologie) * MeSH
- schizofrenie diagnóza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model. METHODS: Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed. RESULTS: The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage. CONCLUSIONS: The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct "cores" of schizophrenia, the "Positive" and the "Negative," while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.
2nd Department of Psychiatry National and Kapodistrian University of Athens Athens Greece
Antwerp Health Law and Ethics Chair AHLEC University Antwerpen Belgium
Clinical Department of Neurology Clinical Centre of Montenegro Podgorica Montenegro
Clinical Department of Psychiatry Clinical Centre of Montenegro Podgorica Montenegro
Department for Psychosis Treatment Vilnius Mental Health Center Vilnius Lithuania
Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Clinic of Psychiatric Faculty of Medicine Vilnius University Vilnius Lithuania
Department of Neurosciences Katholieke Universiteit Leuven Leuven Belgium
Department of Psychiatry and Mental Health Santa Maria University Hospital Lisbon Portugal
Department of Psychiatry and Mental Health University of Cape Town Cape Town South Africa
Department of Psychiatry and Narcology Riga Stradins University Riga Latvia
Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria
Department of Psychiatry and Psychotherapy Semmelweis University Budapest Hungary
Department of Psychiatry College of Medicine University of Ibadan Ibadan Nigeria
Department of Psychiatry Lokmanya Tilak Municipal Medical College Mumbai India
Department of Psychiatry Queen's University Providence Care Hospital Kingston Ontario Canada
Department of Psychiatry Royal College of Surgeons in Ireland Beaumont Hospital Dublin Ireland
Department of Psychiatry Ruhr University Bochum Bochum Germany
Department of Psychiatry Sainte Marguerite University Hospital Marseille France
Department of Psychiatry School of Medicine University of Montenegro Podgorica Montenegro
Department of Psychiatry University of Florida Gainesville Florida USA
Department of Psychiatry University of Melbourne Parkville Victoria Australia
Department of Psychiatry University of Turku Turku Finland
Department of Psychosocial Rehabilitation Vilnius Mental Health Center Vilnius Lithuania
Institute of Mental Health Belgrade Serbia
Institute of Mental Health School of Medicine University of Belgrade Belgrade Serbia
National Institute of Mental Health Klecany Czech Republic
Nyírő Gyula Hospital Budapest Hungary
Orygen The National Centre of Excellence in Youth Mental Health Parkville Victoria Australia
Psychiatry Department Diskapi Yildirim Beyazit Training and Research Hospital Ankara Turkey
Serbian Academy of Sciences and Arts Belgrade Serbia
Timone Institute of Neuroscience Marseille France
University of Medicine and Pharmacy of Târgu Mures Târgu Mures Romania
University of Medicine and Pharmacy of Timisoara Timisoara Romania
University Psychiatric Center Katholieke Universiteit Leuven Kortenberg Belgium
Citace poskytuje Crossref.org
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- $a Fountoulakis, Konstantinos N $u 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece $1 https://orcid.org/0000000155030811
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- $a Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study / $c KN. Fountoulakis, E. Dragioti, AT. Theofilidis, T. Wiklund, X. Atmatzidis, I. Nimatoudis, E. Thys, M. Wampers, L. Hranov, T. Hristova, D. Aptalidis, R. Milev, F. Iftene, F. Spaniel, P. Knytl, P. Furstova, T. From, H. Karlsson, M. Walta, RKR. Salokangas, JM. Azorin, J. Bouniard, J. Montant, G. Juckel, IS. Haussleiter, A. Douzenis, I. Michopoulos, P. Ferentinos, N. Smyrnis, L. Mantonakis, Z. Nemes, X. Gonda, D. Vajda, A. Juhasz, A. Shrivastava, J. Waddington, M. Pompili, A. Comparelli, V. Corigliano, E. Rancans, A. Navickas, J. Hilbig, L. Bukelskis, LI. Stevovic, S. Vodopic, O. Esan, O. Oladele, C. Osunbote, JK. Rybakowski, P. Wojciak, K. Domowicz, ML. Figueira, L. Linhares, J. Crawford, AL. Panfil, D. Smirnova, O. Izmailova, D. Lecic-Tosevski, H. Temmingh, F. Howells, J. Bobes, MP. Garcia-Portilla, L. García-Alvarez, G. Erzin, H. Karadağ, A. De Sousa, A. Bendre, C. Hoschl, C. Bredicean, I. Papava, O. Vukovic, B. Pejuskovic, V. Russell, L. Athanasiadis, A. Konsta, D. Stein, M. Berk, O. Dean, R. Tandon, S. Kasper, M. De Hert
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