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The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation
L. De Roeck, HL. van der Weide, DBP. Eekers, MC. Kramer, C. Alapetite, M. Blomstrand, NG. Burnet, V. Calugaru, IEM. Coremans, D. Di Perri, S. Harrabi, A. Iannalfi, YLB. Klaver, JA. Langendijk, AM. Romero, F. Paulsen, E. Roelofs, D. de Ruysscher,...
Jazyk angličtina Země Irsko
Typ dokumentu časopisecké články, přehledy
- MeSH
- dospělí MeSH
- konsensus MeSH
- lidé MeSH
- mozek MeSH
- nádory baze lební * radioterapie MeSH
- následné studie MeSH
- protonová terapie * škodlivé účinky MeSH
- protony MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
PURPOSE: Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy. METHODS: A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points. RESULTS: In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists are defined. CONCLUSION: These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. With adoptation of this standard, collaboration will be facilitated and we can further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.
Clinic for Particle Therapy University Hospital Essen West German Cancer Center Germany
Danish Centre for Particle Therapy Aarhus Denmark
Department of Oncology Sahlgrenska University Hospital Gothenburg Sweden
Department of Radiation Oncology Cliniques universitaires Saint Luc Brussels Belgium
Department of Radiation Oncology Eberhard Karls Universität Tübingen Germany
Department of Radiotherapy Erasmus MC Cancer Institute Rotterdam The Netherlands
German Cancer Consortium partnersite Essen Germany
German Cancer Research Center Heidelberg Germany
Haaglanden Medisch Centrum Department of Radiotherapy Leidschendam The Netherlands
Holland Proton Therapy Centre Delft The Netherlands
Institut Curie Radiation Oncology Department Paris and Proton Center Orsay France
Institute Curie Centre de Protonthérapie d'Orsay Orsay France
Institute of Radiooncology OncoRay Helmholtz Zentrum Dresden Rossendorf Germany
Leiden University Medical Centre Department of Radiotherapy The Netherlands
Leuven Kanker Instituut UZ Leuven Gasthuisberg Belgium
National Center for Oncological Hadrontherapy Pavia Italy
National Center for Tumour Diseases Partner Site Dresden Germany
Norwegian Radiation and Nuclear Safety Authority Oslo Norway
Particle Therapy Interuniversitary Center Leuven Belgium
Paul Scherrer Institut Center for Proton Therapy ETH Domain Villigen Switzerland
Proton Therapy Center Czech Prague Czech Republic
The Christie NHS Foundation Trust Manchester United Kingdom
University Hospitals Leuven Department of Radiation Oncology Belgium
Citace poskytuje Crossref.org
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- $a De Roeck, Laurien $u KU Leuven, University of Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, Belgium; University Hospitals Leuven, Department of Radiation Oncology, Belgium. Electronic address: Laurien.deroeck@uzleuven.be
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- $a The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation / $c L. De Roeck, HL. van der Weide, DBP. Eekers, MC. Kramer, C. Alapetite, M. Blomstrand, NG. Burnet, V. Calugaru, IEM. Coremans, D. Di Perri, S. Harrabi, A. Iannalfi, YLB. Klaver, JA. Langendijk, AM. Romero, F. Paulsen, E. Roelofs, D. de Ruysscher, B. Timmermann, P. Vitek, DC. Weber, GA. Whitfield, PW. Nyström, J. Zindler, EGC. Troost, M. Lambrecht, work package 1 of the taskforce “European Particle Therapy Network” of ESTRO
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- $a PURPOSE: Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy. METHODS: A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points. RESULTS: In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists are defined. CONCLUSION: These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. With adoptation of this standard, collaboration will be facilitated and we can further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.
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