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The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation

L. De Roeck, HL. van der Weide, DBP. Eekers, MC. Kramer, C. Alapetite, M. Blomstrand, NG. Burnet, V. Calugaru, IEM. Coremans, D. Di Perri, S. Harrabi, A. Iannalfi, YLB. Klaver, JA. Langendijk, AM. Romero, F. Paulsen, E. Roelofs, D. de Ruysscher,...

. 2022 ; 168 (-) : 241-249. [pub] 20220129

Jazyk angličtina Země Irsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22019336

PURPOSE: Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy. METHODS: A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points. RESULTS: In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant, the organ at risk threshold doses for recommended referral to specific organ specialists are defined. CONCLUSION: These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. With adoptation of this standard, collaboration will be facilitated and we can further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.

Clinic for Particle Therapy University Hospital Essen West German Cancer Center Germany

Danish Centre for Particle Therapy Aarhus Denmark

Department of Oncology Sahlgrenska University Hospital Gothenburg Sweden

Department of Radiation Oncology Cliniques universitaires Saint Luc Brussels Belgium

Department of Radiation Oncology Eberhard Karls Universität Tübingen Germany

Department of Radiation Oncology GROW School for Oncology Maastricht University Medical Centre The Netherlands

Department of Radiation Oncology University Medical Center Groningen University of Groningen The Netherlands

Department of Radiotherapy and Radiation Oncology Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universität Dresden Germany

Department of Radiotherapy Erasmus MC Cancer Institute Rotterdam The Netherlands

German Cancer Consortium partnersite Essen Germany

German Cancer Research Center Heidelberg Germany

Haaglanden Medisch Centrum Department of Radiotherapy Leidschendam The Netherlands

Heidelberg Ion Beam Therapy Centre Department of Radiation Oncology University Hospital Heidelberg Heidelberg Germany

Holland Proton Therapy Centre Delft The Netherlands

Institut Curie Radiation Oncology Department Paris and Proton Center Orsay France

Institute Curie Centre de Protonthérapie d'Orsay Orsay France

Institute Curie Paris France

Institute of Radiooncology OncoRay Helmholtz Zentrum Dresden Rossendorf Germany

KU Leuven University of Leuven Department of Oncology Laboratory of Experimental Radiotherapy Belgium

Leiden University Medical Centre Department of Radiotherapy The Netherlands

Leuven Kanker Instituut UZ Leuven Gasthuisberg Belgium

National Center for Oncological Hadrontherapy Pavia Italy

National Center for Tumour Diseases Partner Site Dresden Germany

Norwegian Radiation and Nuclear Safety Authority Oslo Norway

OncoRay National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universität Dresden Helmholtz Zentrum Dresden Rossendorf Germany

Particle Therapy Interuniversitary Center Leuven Belgium

Paul Scherrer Institut Center for Proton Therapy ETH Domain Villigen Switzerland

Proton Therapy Center Czech Prague Czech Republic

The Children's Brain Tumour Research Network University of Manchester Royal Manchester Children's Hospital United Kingdom

The Christie NHS Foundation Trust Manchester United Kingdom

The University of Manchester Manchester Academic Health Science Centre The Christie NHS Foundation Trust United Kingdom

University Hospitals Leuven Department of Radiation Oncology Belgium

West German Proton Therapy Center Essen Germany

Citace poskytuje Crossref.org

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