• Something wrong with this record ?

The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease

T. Hortobágyi, T. Vetrovsky, GM. Balbim, NCB. Sorte Silva, A. Manca, F. Deriu, M. Kolmos, C. Kruuse, T. Liu-Ambrose, Z. Radák, M. Váczi, H. Johansson, PCR. Dos Santos, E. Franzén, U. Granacher

. 2022 ; 80 (-) : 101698. [pub] 20220716

Language English Country England, Great Britain

Document type Journal Article, Meta-Analysis, Review, Systematic Review, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc22024496

OBJECTIVE: To determine the effects of low- vs. high-intensity aerobic and resistance training on motor and cognitive function, brain activation, brain structure, and neurochemical markers of neuroplasticity and the association thereof in healthy young and older adults and in patients with multiple sclerosis, Parkinson's disease, and stroke. DESIGN: Systematic review and robust variance estimation meta-analysis with meta-regression. DATA SOURCES: Systematic search of MEDLINE, Web of Science, and CINAHL databases. RESULTS: Fifty studies with 60 intervention arms and 2283 in-analyses participants were included. Due to the low number of studies, the three patient groups were combined and analyzed as a single group. Overall, low- (g=0.19, p = 0.024) and high-intensity exercise (g=0.40, p = 0.001) improved neuroplasticity. Exercise intensity scaled with neuroplasticity only in healthy young adults but not in healthy older adults or patient groups. Exercise-induced improvements in neuroplasticity were associated with changes in motor but not cognitive outcomes. CONCLUSION: Exercise intensity is an important variable to dose and individualize the exercise stimulus for healthy young individuals but not necessarily for healthy older adults and neurological patients. This conclusion warrants caution because studies are needed that directly compare the effects of low- vs. high-intensity exercise on neuroplasticity to determine if such changes are mechanistically and incrementally linked to improved cognition and motor function.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22024496
003      
CZ-PrNML
005      
20221031100313.0
007      
ta
008      
221017s2022 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.arr.2022.101698 $2 doi
035    __
$a (PubMed)35853549
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Hortobágyi, Tibor $u Center for Human Movement Sciences, University of Groningen Medical Center, Groningen, the Netherlands; Somogy County Kaposi Mór Teaching Hospital, Kaposvár, Hungary; Department of Sport Biology, Institute of Sport Sciences and Physical Education, University of Pécs, Hungary; Division of Training and Movement Sciences, Research Focus Cognition Sciences, University of Potsdam, Potsdam, Germany; Hungarian University of Sports Science, Department of Kinesiology, Budapest, Hungary. Electronic address: t.hortobagyi@umcg.nl
245    14
$a The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease / $c T. Hortobágyi, T. Vetrovsky, GM. Balbim, NCB. Sorte Silva, A. Manca, F. Deriu, M. Kolmos, C. Kruuse, T. Liu-Ambrose, Z. Radák, M. Váczi, H. Johansson, PCR. Dos Santos, E. Franzén, U. Granacher
520    9_
$a OBJECTIVE: To determine the effects of low- vs. high-intensity aerobic and resistance training on motor and cognitive function, brain activation, brain structure, and neurochemical markers of neuroplasticity and the association thereof in healthy young and older adults and in patients with multiple sclerosis, Parkinson's disease, and stroke. DESIGN: Systematic review and robust variance estimation meta-analysis with meta-regression. DATA SOURCES: Systematic search of MEDLINE, Web of Science, and CINAHL databases. RESULTS: Fifty studies with 60 intervention arms and 2283 in-analyses participants were included. Due to the low number of studies, the three patient groups were combined and analyzed as a single group. Overall, low- (g=0.19, p = 0.024) and high-intensity exercise (g=0.40, p = 0.001) improved neuroplasticity. Exercise intensity scaled with neuroplasticity only in healthy young adults but not in healthy older adults or patient groups. Exercise-induced improvements in neuroplasticity were associated with changes in motor but not cognitive outcomes. CONCLUSION: Exercise intensity is an important variable to dose and individualize the exercise stimulus for healthy young individuals but not necessarily for healthy older adults and neurological patients. This conclusion warrants caution because studies are needed that directly compare the effects of low- vs. high-intensity exercise on neuroplasticity to determine if such changes are mechanistically and incrementally linked to improved cognition and motor function.
650    _2
$a senioři $7 D000368
650    _2
$a biologické markery $7 D015415
650    _2
$a kognice $x fyziologie $7 D003071
650    _2
$a cvičení $x fyziologie $7 D015444
650    _2
$a lidé $7 D006801
650    12
$a roztroušená skleróza $7 D009103
650    _2
$a neuroplasticita $7 D009473
650    12
$a odporový trénink $7 D055070
655    _2
$a časopisecké články $7 D016428
655    _2
$a metaanalýza $7 D017418
655    _2
$a přehledy $7 D016454
655    _2
$a systematický přehled $7 D000078182
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Vetrovsky, Tomas $u Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic
700    1_
$a Balbim, Guilherme Moraes $u Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada
700    1_
$a Sorte Silva, Nárlon Cássio Boa $u Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada
700    1_
$a Manca, Andrea $u Department of Biomedical Sciences, University of Sassari, Sassari, Italy
700    1_
$a Deriu, Franca $u Department of Biomedical Sciences, University of Sassari, Sassari, Italy; Unit of Endocrinology, Nutritional and Metabolic Disorders, AOU Sassari, Sassari, Italy
700    1_
$a Kolmos, Mia $u Neurovascular Research Unit, Department of Neurology, Herlev Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
700    1_
$a Kruuse, Christina $u Neurovascular Research Unit, Department of Neurology, Herlev Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
700    1_
$a Liu-Ambrose, Teresa $u Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada
700    1_
$a Radák, Zsolt $u Research Center of Molecular Exercise Science, Hungarian University of Sport Science, Budapest, Hungary
700    1_
$a Váczi, Márk $u Department of Sport Biology, Institute of Sport Sciences and Physical Education, University of Pécs, Hungary
700    1_
$a Johansson, Hanna $u Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden; Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden
700    1_
$a Dos Santos, Paulo Cezar Rocha $u Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel
700    1_
$a Franzén, Erika $u Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden; Women's Health and Allied Health Professionals Theme, Medical Unit Occupational Therapy & Physiotherapy, Karolinska University Hospital, Stockholm, Sweden
700    1_
$a Granacher, Urs $u Division of Training and Movement Sciences, Research Focus Cognition Sciences, University of Potsdam, Potsdam, Germany
773    0_
$w MED00008553 $t Ageing research reviews $x 1872-9649 $g Roč. 80, č. - (2022), s. 101698
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35853549 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20221017 $b ABA008
991    __
$a 20221031100311 $b ABA008
999    __
$a ok $b bmc $g 1854292 $s 1175786
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 80 $c - $d 101698 $e 20220716 $i 1872-9649 $m Ageing research reviews $n Ageing Res Rev $x MED00008553
LZP    __
$a Pubmed-20221017

Find record

Citation metrics

Archiving options