Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

A Multidisciplinary Hypothesis about Serotonergic Psychedelics. Is it Possible that a Portion of Brain Serotonin Comes From the Gut

N. Császár-Nagy, P. Bob, I. Bókkon

. 2022 ; 21 (5) : 148. [pub] 2022Aug31

Jazyk angličtina Země Singapur

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22024704

Here we present a complex hypothesis about the psychosomatic mechanism of serotonergic psychedelics. Serotonergic psychedelics affect gut microbes that produce a temporary increase of 5-HT by their host enterochromaffin cells (ECs). This increased 5-HT production-which is taken up and distributed by platelets-may work as a hormone-like regulatory signal that could influence membrane permeability in the host organs and tissues and in the brain. Increased plasma 5-HT levels could enhance permeability of the blood-brain barrier (BBB). Transiently increased permeability of the BBB allows for plasma 5-HT to enter the central nervous system (CNS) and be distributed by the volume transmission. Next, this gut-derived 5-HT could modulate excitatory and inhibitory neurotransmission and produce special network disintegration in the CNS. This transient perturbation of the normal neural hierarchy allows patients access to suppressed fear information and perform an emotional reset, in which the amygdale may have a key role.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22024704
003      
CZ-PrNML
005      
20221031100500.0
007      
ta
008      
221017s2022 si f 000 0|eng||
009      
AR
024    7_
$a 10.31083/j.jin2105148 $2 doi
035    __
$a (PubMed)36137971
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a si
100    1_
$a Császár-Nagy, Noémi $u National University of Public Services, H-1083 Budapest, Hungary $u Psychosomatic Outpatient Clinics, H-1037 Budapest, Hungary
245    12
$a A Multidisciplinary Hypothesis about Serotonergic Psychedelics. Is it Possible that a Portion of Brain Serotonin Comes From the Gut / $c N. Császár-Nagy, P. Bob, I. Bókkon
520    9_
$a Here we present a complex hypothesis about the psychosomatic mechanism of serotonergic psychedelics. Serotonergic psychedelics affect gut microbes that produce a temporary increase of 5-HT by their host enterochromaffin cells (ECs). This increased 5-HT production-which is taken up and distributed by platelets-may work as a hormone-like regulatory signal that could influence membrane permeability in the host organs and tissues and in the brain. Increased plasma 5-HT levels could enhance permeability of the blood-brain barrier (BBB). Transiently increased permeability of the BBB allows for plasma 5-HT to enter the central nervous system (CNS) and be distributed by the volume transmission. Next, this gut-derived 5-HT could modulate excitatory and inhibitory neurotransmission and produce special network disintegration in the CNS. This transient perturbation of the normal neural hierarchy allows patients access to suppressed fear information and perform an emotional reset, in which the amygdale may have a key role.
650    _2
$a hematoencefalická bariéra $7 D001812
650    _2
$a mozek $7 D001921
650    12
$a halucinogeny $7 D006213
650    _2
$a hormony $7 D006728
650    _2
$a lidé $7 D006801
650    12
$a serotonin $7 D012701
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Bob, Petr $u Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry & UHSL, First Faculty of Medicine, and Department of Psychiatry, Faculty of Medicine Pilsen, Charles University, CZ-12108 Prague, Czechia
700    1_
$a Bókkon, István $u Psychosomatic Outpatient Clinics, H-1037 Budapest, Hungary $u Neuroscience and Consciousness Research Department, Vision Research Institute, Lowell, MA 01854 USA
773    0_
$w MED00008014 $t Journal of integrative neuroscience $x 0219-6352 $g Roč. 21, č. 5 (2022), s. 148
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36137971 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20221017 $b ABA008
991    __
$a 20221031100457 $b ABA008
999    __
$a ok $b bmc $g 1854442 $s 1175994
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 21 $c 5 $d 148 $e 2022Aug31 $i 0219-6352 $m Journal of integrative neuroscience $n J Integr Neurosci $x MED00008014
LZP    __
$a Pubmed-20221017

Najít záznam

Citační ukazatele

Možnosti archivace