-
Something wrong with this record ?
Rescue left bundle branch area pacing in coronary venous lead failure or nonresponse to biventricular pacing: Results from International LBBAP Collaborative Study Group
P. Vijayaraman, B. Herweg, A. Verma, PS. Sharma, SA. Batul, SS. Ponnusamy, RD. Schaller, O. Cano, M. Molina-Lerma, K. Curila, W. Huybrechts, DR. Wilson, LM. Rademakers, P. Sreekumar, G. Upadhyay, K. Vernooy, FA. Subzposh, W. Huang, M....
Language English Country United States
Document type Journal Article
- MeSH
- Bundle-Branch Block diagnosis etiology therapy MeSH
- Electrocardiography methods MeSH
- Ventricular Function, Left physiology MeSH
- Bundle of His MeSH
- Cardiac Pacing, Artificial methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Arrhythmias, Cardiac therapy MeSH
- Cardiac Resynchronization Therapy * methods MeSH
- Heart Failure * diagnosis etiology therapy MeSH
- Stroke Volume MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: Cardiac resynchronization therapy (CRT) using biventricular pacing (BVP) is effective in patients with heart failure, left bundle branch block (LBBB), and reduced left ventricular function. Left bundle branch area pacing (LBBAP) has been reported as an alternative option for CRT. OBJECTIVE: The purpose of this study was to assess the feasibility and outcomes of LBBAP in patients who failed conventional BVP because of coronary venous (CV) lead complications or who were nonresponders to BVP. METHODS: At 16 international centers, LBBAP was attempted in patients with conventional CRT indication who failed BVP because of CV lead complications or lack of therapeutic response to BVP. Heart failure hospitalization (HFH) and death, echocardiographic outcomes, procedural data, pacing parameters, and lead complications including CV lead failure are reported. RESULTS: LBBAP was successfully performed in 200 patients (CV lead failures 156; nonresponders 44) (age 68 ± 11 years; female 35%; LBBB 55%; right ventricular pacing 23%; ischemic cardiomyopathy 28%; nonischemic cardiomyopathy 63%; left ventricular ejection fraction [LVEF] ≤35% in 80%). Procedural duration was 119.5 ± 59.6 minutes, and fluoroscopy duration was 25.7 ± 18.5 minutes. LBBAP threshold and R-wave amplitudes were 0.68 ± 0.35 V @ 0.45 ms and 10.4 ± 5 mV at implant, respectively, and remained stable during mean follow-up of 12 ± 10.1 months. LBBAP resulted in significant QRS narrowing from 170 ± 28 ms to 139 ± 25 ms (P <.001) with V6 R-wave peak times of 85 ± 17 ms. LVEF improved from 29% ± 10% at baseline to 40% ± 12% (P <.001) during follow-up. The risk of death or HFH was lower in those with CV lead failure than in nonresponders (hazard ratio 0.357; 95% confidence interval 0.168-0.756; P = .007) CONCLUSION: LBBAP is a viable alternative to CRT in patients who failed conventional BVP due to CV lead failure or who were nonresponders.
Department of Cardiology Cardiovascular Research Institute Maastricht Maastricht The Netherlands
Department of Cardiology Catharina Ziekenhuis Eindhoven The Netherlands
Department of Cardiology University Hospital Antwerp Belgium
Division of Cardiology University of South Florida Tampa Florida
Electrophysiology Unit Department of Cardiology Aster Medcity Kochi Kerala India
Geisinger Heart Institute Wilkes Barre Pennsylvania
Rush University Medical Center Chicago Illinois
South Lake Regional Health Center University of Toronto Toronto Canada
University of Chicago Chicago Illinois
Virgen de las Nieves Hospital Granada Spain
Virginia Commonwealth University Health System Richmond Virginia
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22025034
- 003
- CZ-PrNML
- 005
- 20221031100821.0
- 007
- ta
- 008
- 221017s2022 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.hrthm.2022.04.024 $2 doi
- 035 __
- $a (PubMed)35504539
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Vijayaraman, Pugazhendhi $u Geisinger Heart Institute, Wilkes-Barre, Pennsylvania. Electronic address: pvijayaraman1@geisinger.edu
- 245 10
- $a Rescue left bundle branch area pacing in coronary venous lead failure or nonresponse to biventricular pacing: Results from International LBBAP Collaborative Study Group / $c P. Vijayaraman, B. Herweg, A. Verma, PS. Sharma, SA. Batul, SS. Ponnusamy, RD. Schaller, O. Cano, M. Molina-Lerma, K. Curila, W. Huybrechts, DR. Wilson, LM. Rademakers, P. Sreekumar, G. Upadhyay, K. Vernooy, FA. Subzposh, W. Huang, M. Jastrzebski, KA. Ellenbogen
- 520 9_
- $a BACKGROUND: Cardiac resynchronization therapy (CRT) using biventricular pacing (BVP) is effective in patients with heart failure, left bundle branch block (LBBB), and reduced left ventricular function. Left bundle branch area pacing (LBBAP) has been reported as an alternative option for CRT. OBJECTIVE: The purpose of this study was to assess the feasibility and outcomes of LBBAP in patients who failed conventional BVP because of coronary venous (CV) lead complications or who were nonresponders to BVP. METHODS: At 16 international centers, LBBAP was attempted in patients with conventional CRT indication who failed BVP because of CV lead complications or lack of therapeutic response to BVP. Heart failure hospitalization (HFH) and death, echocardiographic outcomes, procedural data, pacing parameters, and lead complications including CV lead failure are reported. RESULTS: LBBAP was successfully performed in 200 patients (CV lead failures 156; nonresponders 44) (age 68 ± 11 years; female 35%; LBBB 55%; right ventricular pacing 23%; ischemic cardiomyopathy 28%; nonischemic cardiomyopathy 63%; left ventricular ejection fraction [LVEF] ≤35% in 80%). Procedural duration was 119.5 ± 59.6 minutes, and fluoroscopy duration was 25.7 ± 18.5 minutes. LBBAP threshold and R-wave amplitudes were 0.68 ± 0.35 V @ 0.45 ms and 10.4 ± 5 mV at implant, respectively, and remained stable during mean follow-up of 12 ± 10.1 months. LBBAP resulted in significant QRS narrowing from 170 ± 28 ms to 139 ± 25 ms (P <.001) with V6 R-wave peak times of 85 ± 17 ms. LVEF improved from 29% ± 10% at baseline to 40% ± 12% (P <.001) during follow-up. The risk of death or HFH was lower in those with CV lead failure than in nonresponders (hazard ratio 0.357; 95% confidence interval 0.168-0.756; P = .007) CONCLUSION: LBBAP is a viable alternative to CRT in patients who failed conventional BVP due to CV lead failure or who were nonresponders.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a srdeční arytmie $x terapie $7 D001145
- 650 _2
- $a Hisův svazek $7 D002036
- 650 _2
- $a blokáda Tawarova raménka $x diagnóza $x etiologie $x terapie $7 D002037
- 650 _2
- $a kardiostimulace umělá $x metody $7 D002304
- 650 12
- $a srdeční resynchronizační terapie $x metody $7 D058406
- 650 _2
- $a elektrokardiografie $x metody $7 D004562
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a srdeční selhání $x diagnóza $x etiologie $x terapie $7 D006333
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a tepový objem $7 D013318
- 650 _2
- $a výsledek terapie $7 D016896
- 650 _2
- $a funkce levé komory srdeční $x fyziologie $7 D016277
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Herweg, Bengt $u Division of Cardiology, University of South Florida, Tampa, Florida
- 700 1_
- $a Verma, Atul $u South Lake Regional Health Center, University of Toronto, Toronto, Canada
- 700 1_
- $a Sharma, Parikshit S $u Rush University Medical Center, Chicago, Illinois
- 700 1_
- $a Batul, Syeda Atiqa $u Geisinger Heart Institute, Wilkes-Barre, Pennsylvania
- 700 1_
- $a Ponnusamy, Shunmuga Sundaram $u Department of Cardiology, Velammal Medical College Hospital and Research Institute, Velammal Village, Madurai, Tamil Nadu, India
- 700 1_
- $a Schaller, Robert D $u Division of Cardiovascular Medicine, Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
- 700 1_
- $a Cano, Oscar $u Hospital Universitari i Politècnic La Fe, Valencia, Spain, and Centro de Investigaciones Biomédicas en RED en Enfermedades Cardiovasculares (CIBERCV)
- 700 1_
- $a Molina-Lerma, Manuel $u Virgen de las Nieves Hospital, Granada, Spain
- 700 1_
- $a Curila, Karol $u Cardiocenter, University Hospital Kralovske Vinohrady and 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
- 700 1_
- $a Huybrechts, Wim $u Department of Cardiology, University Hospital Antwerp, Belgium
- 700 1_
- $a Wilson, David R $u Division of Cardiology, University of South Florida, Tampa, Florida
- 700 1_
- $a Rademakers, Leonard M $u Department of Cardiology, Catharina Ziekenhuis, Eindhoven, The Netherlands
- 700 1_
- $a Sreekumar, Praveen $u Electrophysiology Unit, Department of Cardiology Aster Medcity, Kochi, Kerala, India
- 700 1_
- $a Upadhyay, Gaurav $u University of Chicago, Chicago, Illinois
- 700 1_
- $a Vernooy, Kevin $u Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands
- 700 1_
- $a Subzposh, Faiz A $u Geisinger Heart Institute, Wilkes-Barre, Pennsylvania
- 700 1_
- $a Huang, Weijian $u Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, and The Key Lab of Cardiovascular Disease of Wenzhou, Wenzhou, China
- 700 1_
- $a Jastrzebski, Marek $u First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University, Medical College, Krakow, Poland
- 700 1_
- $a Ellenbogen, Kenneth A $u Virginia Commonwealth University Health System, Richmond, Virginia
- 773 0_
- $w MED00156180 $t Heart rhythm $x 1556-3871 $g Roč. 19, č. 8 (2022), s. 1272-1280
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35504539 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20221017 $b ABA008
- 991 __
- $a 20221031100819 $b ABA008
- 999 __
- $a ok $b bmc $g 1854637 $s 1176324
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 19 $c 8 $d 1272-1280 $e 20220430 $i 1556-3871 $m Heart rhythm $n Heart Rhythm $x MED00156180
- LZP __
- $a Pubmed-20221017
