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Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)
A. Olsson, N. Guha, L. Bouaoun, H. Kromhout, S. Peters, J. Siemiatycki, V. Ho, P. Gustavsson, P. Boffetta, R. Vermeulen, T. Behrens, T. Brüning, B. Kendzia, P. Guénel, D. Luce, S. Karrasch, HE. Wichmann, D. Consonni, MT. Landi, NE. Caporaso, F....
Language English Country United States
Document type Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1991 to 1 year ago
Freely Accessible Science Journals
from 1991 to 12 months ago
Open Access Digital Library
from 1991-11-01
Open Access Digital Library
from 1991-11-01
- MeSH
- Carcinogens MeSH
- Humans MeSH
- Lung Neoplasms * chemically induced epidemiology MeSH
- Lung MeSH
- Polycyclic Aromatic Hydrocarbons * adverse effects MeSH
- Occupational Exposure * adverse effects analysis MeSH
- Case-Control Studies MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Exposure to polycyclic aromatic hydrocarbons (PAH) occurs widely in occupational settings. We investigated the association between occupational exposure to PAH and lung cancer risk and joint effects with smoking within the SYNERGY project. METHODS: We pooled 14 case-control studies with information on lifetime occupational and smoking histories conducted between 1985 and 2010 in Europe and Canada. Exposure to benzo[a]pyrene (BaP) was used as a proxy of PAH and estimated from a quantitative general population job-exposure matrix. Multivariable unconditional logistic regression models, adjusted for smoking and exposure to other occupational lung carcinogens, estimated ORs, and 95% confidence intervals (CI). RESULTS: We included 16,901 lung cancer cases and 20,965 frequency-matched controls. Adjusted OR for PAH exposure (ever) was 1.08 (CI, 1.02-1.15) in men and 1.20 (CI, 1.04-1.38) in women. When stratified by smoking status and histologic subtype, the OR for cumulative exposure ≥0.24 BaP μg/m3-years in men was higher in never smokers overall [1.31 (CI, 0.98-1.75)], for small cell [2.53 (CI, 1.28-4.99)] and squamous cell cancers [1.33 (CI, 0.80-2.21)]. Joint effects between PAH and smoking were observed. Restricting analysis to the most recent studies showed no increased risk. CONCLUSIONS: Elevated lung cancer risk associated with PAH exposure was observed in both sexes, particularly for small cell and squamous cell cancers, after accounting for cigarette smoking and exposure to other occupational lung carcinogens. IMPACT: The lack of association between PAH and lung cancer in more recent studies merits further research under today's exposure conditions and worker protection measures.
Cancer Epidemiology Unit Department of Medical Sciences University of Turin Turin Italy
Comprehensive Pneumology Center Munich Munich Germany
Dalla Lana School of Public Health University of Toronto Toronto Canada
Department of Environmental Epidemiology The Nofer Institute of Occupational Medicine Lodz Poland
Department of Epidemiology ASL Roma E Rome Italy
Department of Medical and Surgical Sciences University of Bologna Bologna Italy
Department of Public Health University of Oviedo ISPA and CIBERESP Oviedo Spain
Department of Social and Preventive Medicine University of Montreal Montreal Canada
Division of Cancer Epidemiology and Genetics NCI NIH Bethesda Maryland
Epidemiology Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy
Faculty of Health Catholic University Ružomberok Slovakia
Faculty of Health Sciences Palacky University Olomouc Czechia
Institute for Medical Informatics Biometry and Epidemiology University Hospital Essen Essen Germany
Institute for Risk Assessment Sciences Utrecht University Utrecht the Netherlands
Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
Institute of Hygiene and Epidemiology 1st Faculty of Medicine Charles University Prague Czechia
International Agency for Research on Cancer Lyon France
Leibniz Institute for Prevention Research and Epidemiology BIPS Bremen Germany
Masaryk Memorial Cancer Institute Brno Czechia
National Institute of Public Health Bucharest Romania
National Public Health Center Budapest Hungary
Occupational Cancer Research Centre Ontario Health Toronto Canada
Regional Authority of Public Health Banská Bystrica Slovakia
Stony Brook Cancer Center Stony Brook University Stony Brook New York
Univ Rennes Inserm EHESP Irset UMR_S 1085 Pointe à Pitre France
References provided by Crossref.org
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