-
Je něco špatně v tomto záznamu ?
Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans
J. Dobeš, O. Ben-Nun, A. Binyamin, L. Stoler-Barak, BE. Oftedal, Y. Goldfarb, N. Kadouri, Y. Gruper, T. Givony, I. Zalayat, K. Kováčová, H. Böhmová, E. Valter, Z. Shulman, D. Filipp, ES. Husebye, J. Abramson
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
ProQuest Central
od 2000-07-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-07-01 do Před 1 rokem
- MeSH
- autoimunitní nemoci * MeSH
- autoimunitní polyglandulární syndromy * genetika MeSH
- buňky Th17 MeSH
- Candida albicans MeSH
- kandidóza * genetika MeSH
- lidé MeSH
- přirozená imunita MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Patients with loss of function in the gene encoding the master regulator of central tolerance AIRE suffer from a devastating disorder called autoimmune polyendocrine syndrome type 1 (APS-1), characterized by a spectrum of autoimmune diseases and severe mucocutaneous candidiasis. Although the key mechanisms underlying the development of autoimmunity in patients with APS-1 are well established, the underlying cause of the increased susceptibility to Candida albicans infection remains less understood. Here, we show that Aire+MHCII+ type 3 innate lymphoid cells (ILC3s) could sense, internalize and present C. albicans and had a critical role in the induction of Candida-specific T helper 17 (TH17) cell clones. Extrathymic Rorc-Cre-mediated deletion of Aire resulted in impaired generation of Candida-specific TH17 cells and subsequent overgrowth of C. albicans in the mucosal tissues. Collectively, our observations identify a previously unrecognized regulatory mechanism for effective defense responses against fungal infections.
Department of Cell Biology Faculty of Science Charles University Prague Czech Republic
Department of Clinical Science University of Bergen Bergen Norway
Department of Immunology Weizmann Institute of Science Rehovot Israel
Department of Medicine Haukeland University Hospital Bergen Norway
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22025355
- 003
- CZ-PrNML
- 005
- 20221031100818.0
- 007
- ta
- 008
- 221017s2022 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41590-022-01247-6 $2 doi
- 035 __
- $a (PubMed)35761088
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Dobeš, Jan $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel $u Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic $1 https://orcid.org/0000000318531603
- 245 10
- $a Extrathymic expression of Aire controls the induction of effective TH17 cell-mediated immune response to Candida albicans / $c J. Dobeš, O. Ben-Nun, A. Binyamin, L. Stoler-Barak, BE. Oftedal, Y. Goldfarb, N. Kadouri, Y. Gruper, T. Givony, I. Zalayat, K. Kováčová, H. Böhmová, E. Valter, Z. Shulman, D. Filipp, ES. Husebye, J. Abramson
- 520 9_
- $a Patients with loss of function in the gene encoding the master regulator of central tolerance AIRE suffer from a devastating disorder called autoimmune polyendocrine syndrome type 1 (APS-1), characterized by a spectrum of autoimmune diseases and severe mucocutaneous candidiasis. Although the key mechanisms underlying the development of autoimmunity in patients with APS-1 are well established, the underlying cause of the increased susceptibility to Candida albicans infection remains less understood. Here, we show that Aire+MHCII+ type 3 innate lymphoid cells (ILC3s) could sense, internalize and present C. albicans and had a critical role in the induction of Candida-specific T helper 17 (TH17) cell clones. Extrathymic Rorc-Cre-mediated deletion of Aire resulted in impaired generation of Candida-specific TH17 cells and subsequent overgrowth of C. albicans in the mucosal tissues. Collectively, our observations identify a previously unrecognized regulatory mechanism for effective defense responses against fungal infections.
- 650 12
- $a autoimunitní nemoci $7 D001327
- 650 _2
- $a Candida albicans $7 D002176
- 650 12
- $a kandidóza $x genetika $7 D002177
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a přirozená imunita $7 D007113
- 650 12
- $a autoimunitní polyglandulární syndromy $x genetika $7 D016884
- 650 _2
- $a buňky Th17 $7 D058504
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Ben-Nun, Osher $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- 700 1_
- $a Binyamin, Amit $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel $1 https://orcid.org/0000000200460029
- 700 1_
- $a Stoler-Barak, Liat $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- 700 1_
- $a Oftedal, Bergithe E $u Department of Clinical Science, University of Bergen, Bergen, Norway $u Department of Medicine, Haukeland University Hospital, Bergen, Norway $1 https://orcid.org/0000000342487737
- 700 1_
- $a Goldfarb, Yael $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- 700 1_
- $a Kadouri, Noam $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel $1 https://orcid.org/0000000229784318
- 700 1_
- $a Gruper, Yael $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- 700 1_
- $a Givony, Tal $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- 700 1_
- $a Zalayat, Itay $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
- 700 1_
- $a Kováčová, Katarína $u Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic $1 https://orcid.org/0000000207184047
- 700 1_
- $a Böhmová, Helena $u Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic
- 700 1_
- $a Valter, Evgeny $u Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic
- 700 1_
- $a Shulman, Ziv $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel $1 https://orcid.org/000000029604212X
- 700 1_
- $a Filipp, Dominik $u Laboratory of Immunobiology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic $1 https://orcid.org/0000000325069330
- 700 1_
- $a Husebye, Eystein S $u Department of Clinical Science, University of Bergen, Bergen, Norway $u Department of Medicine, Haukeland University Hospital, Bergen, Norway
- 700 1_
- $a Abramson, Jakub $u Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. jakub.abramson@weizmann.ac.il $1 https://orcid.org/0000000217458996
- 773 0_
- $w MED00005448 $t Nature immunology $x 1529-2916 $g Roč. 23, č. 7 (2022), s. 1098-1108
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35761088 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20221017 $b ABA008
- 991 __
- $a 20221031100816 $b ABA008
- 999 __
- $a ok $b bmc $g 1854862 $s 1176645
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 23 $c 7 $d 1098-1108 $e 20220627 $i 1529-2916 $m Nature immunology $n Nat Immunol $x MED00005448
- LZP __
- $a Pubmed-20221017
