• Je něco špatně v tomto záznamu ?

Lipid emulsions prevent postoperative abdominal adhesions

M. Sirovy, M. Krupova, R. Hyspler, A. Ticha, M. Kolackova, C. Andrys, V. Radochova, D. Astapenko, S. Odlozilová, J. Kotek, J. Zajak, J. Paral

. 2023 ; 46 (1) : 465-471. [pub] 20220607

Jazyk angličtina Země Čína

Typ dokumentu časopisecké články, randomizované kontrolované studie veterinární

Perzistentní odkaz   https://www.medvik.cz/link/bmc22032087

INTRODUCTION: Adhesions are the most common cause of long-term morbidity after abdominal surgery and most often cause various forms of intestinal passage disorders ranging from partial obstruction to complete, life-threatening intestinal obstruction. The aim of the present study was to evaluate the protective effect of intraperitoneally administered lipid emulsions on the formation of adhesions in larger animal model, as the lubricating effect of phospholipids and the mechanical barrier of the lipid component are combined with the anti-inflammatory effect of fish oil. METHODS: Thirty-one female domestic pigs were randomly divided into three groups. At the end of the surgical procedure, a lipid emulsion or saline solution was applied intraperitoneally. After 14 days, an independent macroscopic, histological and immunohistochemical evaluation of the adhesions were performed. RESULTS: Intraperitoneal administration of lipid emulsions significantly reduced the incidence of intra-abdominal adhesions. Microscopic examination demonstrated a significant reduction in the number of inflammatory elements and the amount of collagen in the adhesions, especially after administration of the fish oil-based emulsion. A simultaneous decrease in neovascularization was observed in the adhesions. Evaluation of the intestinal anastomosis did not reveal significant differences in healing between the groups. CONCLUSION: Intraperitoneal administration of lipid emulsions can reduce the development of postoperative intra-abdominal adhesions by the combined action of phospholipids as important lubricants and lipids as a mechanical barrier. Their effect is caused by a reduction in proinflammatory and profibrotic mediators. At the same time, intraperitoneal administration of lipid emulsions does not impair healing of the anastomosis in larger animal model.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22032087
003      
CZ-PrNML
005      
20230815105148.0
007      
ta
008      
230120s2023 cc f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.asjsur.2022.05.119 $2 doi
035    __
$a (PubMed)35688763
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a cc
100    1_
$a Sirovy, Miroslav $u University of Defense, Faculty of Military Health Science, Department of Military Surgery, Hradec Kralove, Czech Republic; Department of Surgery, University Hospital and Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic. Electronic address: miroslav.sirovy@fnhk.cz
245    10
$a Lipid emulsions prevent postoperative abdominal adhesions / $c M. Sirovy, M. Krupova, R. Hyspler, A. Ticha, M. Kolackova, C. Andrys, V. Radochova, D. Astapenko, S. Odlozilová, J. Kotek, J. Zajak, J. Paral
520    9_
$a INTRODUCTION: Adhesions are the most common cause of long-term morbidity after abdominal surgery and most often cause various forms of intestinal passage disorders ranging from partial obstruction to complete, life-threatening intestinal obstruction. The aim of the present study was to evaluate the protective effect of intraperitoneally administered lipid emulsions on the formation of adhesions in larger animal model, as the lubricating effect of phospholipids and the mechanical barrier of the lipid component are combined with the anti-inflammatory effect of fish oil. METHODS: Thirty-one female domestic pigs were randomly divided into three groups. At the end of the surgical procedure, a lipid emulsion or saline solution was applied intraperitoneally. After 14 days, an independent macroscopic, histological and immunohistochemical evaluation of the adhesions were performed. RESULTS: Intraperitoneal administration of lipid emulsions significantly reduced the incidence of intra-abdominal adhesions. Microscopic examination demonstrated a significant reduction in the number of inflammatory elements and the amount of collagen in the adhesions, especially after administration of the fish oil-based emulsion. A simultaneous decrease in neovascularization was observed in the adhesions. Evaluation of the intestinal anastomosis did not reveal significant differences in healing between the groups. CONCLUSION: Intraperitoneal administration of lipid emulsions can reduce the development of postoperative intra-abdominal adhesions by the combined action of phospholipids as important lubricants and lipids as a mechanical barrier. Their effect is caused by a reduction in proinflammatory and profibrotic mediators. At the same time, intraperitoneal administration of lipid emulsions does not impair healing of the anastomosis in larger animal model.
650    _2
$a zvířata $7 D000818
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a anastomóza chirurgická $x metody $7 D000714
650    _2
$a emulze $7 D004655
650    12
$a rybí oleje $x terapeutické užití $7 D005395
650    12
$a pooperační komplikace $x prevence a kontrola $x patologie $7 D011183
650    _2
$a adheze tkání $x etiologie $x prevence a kontrola $x patologie $7 D000267
655    _2
$a časopisecké články $7 D016428
655    _2
$a randomizované kontrolované studie veterinární $7 D000081262
700    1_
$a Krupova, Marketa $u Fingerland Department of Pathology, Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic
700    1_
$a Hyspler, Radomir $u Center for Development and Research, University Hospital, Hradec Kralove, Czech Republic
700    1_
$a Ticha, Alena $u Center for Development and Research, University Hospital, Hradec Kralove, Czech Republic
700    1_
$a Kolackova, Martina $u Department of Clinical Immunology and Allergology, Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic
700    1_
$a Andrys, Ctirad $u Department of Clinical Immunology and Allergology, Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic
700    1_
$a Radochova, Vera $u Department of Vivarium, University of Defense, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
700    1_
$a Astapenko, David $u Department of Anesthesiology, Resuscitation and Intensive Care Medicine, University Hospital, Hradec Kralove, Faculty of Medicine, Charles University, Czech Republic
700    1_
$a Odlozilová, Sarka $u University of Defense, Faculty of Military Health Science, Department of Military Surgery, Hradec Kralove, Czech Republic; Department of Surgery, University Hospital and Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic
700    1_
$a Kotek, Jiří $u University of Defense, Faculty of Military Health Science, Department of Military Surgery, Hradec Kralove, Czech Republic; Department of Surgery, University Hospital and Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic $7 xx0305380
700    1_
$a Zajak, Jan $u University of Defense, Faculty of Military Health Science, Department of Military Surgery, Hradec Kralove, Czech Republic; Department of Surgery, University Hospital and Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic
700    1_
$a Paral, Jiri $u University of Defense, Faculty of Military Health Science, Department of Military Surgery, Hradec Kralove, Czech Republic; Department of Surgery, University Hospital and Charles University, Faculty of Medicine, Hradec Kralove, Czech Republic
773    0_
$w MED00005710 $t Asian journal of surgery $x 0219-3108 $g Roč. 46, č. 1 (2023), s. 465-471
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35688763 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230815105144 $b ABA008
999    __
$a ok $b bmc $g 1891083 $s 1183422
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 46 $c 1 $d 465-471 $e 20220607 $i 0219-3108 $m Asian journal of surgery $n Asian J Surg $x MED00005710
LZP    __
$a Pubmed-20230120

Najít záznam

Citační ukazatele

Možnosti archivace