Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19

MPJ. Visser, J. Walk, C. Vermeer, S. Bílková, R. Janssen, O. Mayer

. 2022 ; 125 (-) : 275-277. [pub] 20221028

Language English Country Canada

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc22032282

OBJECTIVES: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown. METHODS: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results. RESULTS: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients. CONCLUSION: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22032282
003      
CZ-PrNML
005      
20230131151546.0
007      
ta
008      
230120s2022 xxc f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ijid.2022.10.030 $2 doi
035    __
$a (PubMed)36511328
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxc
100    1_
$a Visser, Margot P J $u Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands. Electronic address: m.visser@cwz.nl
245    10
$a Enhanced vitamin K expenditure as a major contributor to vitamin K deficiency in COVID-19 / $c MPJ. Visser, J. Walk, C. Vermeer, S. Bílková, R. Janssen, O. Mayer
520    9_
$a OBJECTIVES: Vitamin K deficiency consistently associates with worse clinical outcome in COVID-19 patients. However, whether this is due to increased expenditure during inflammation or poor vitamin K status prior to infection remained unknown. METHODS: Dp-ucMGP levels of 128 individuals were measured for the post-MONICA study and were compared to SARS-CoV-2 PCR testing results. RESULTS: Dp-ucMGP levels prior to COVID-19 infection were not significantly different comparing PCR-negative, PCR-positive and not hospitalized, and PCR-positive and hospitalized patients. CONCLUSION: In this study, we demonstrate normal vitamin K status prior to infection in SARS-CoV-2 positive patients, supporting the theory of increased utilisation during disease.
650    _2
$a lidé $7 D006801
650    _2
$a vitamin K $7 D014812
650    _2
$a výdaje na zdravotnictví $7 D005102
650    _2
$a extracelulární matrix - proteiny $7 D016326
650    _2
$a proteiny vázající vápník $7 D002135
650    12
$a COVID-19 $7 D000086382
650    _2
$a SARS-CoV-2 $7 D000086402
650    12
$a nedostatek vitaminu K $x komplikace $7 D014813
650    _2
$a biologické markery $7 D015415
655    _2
$a časopisecké články $7 D016428
700    1_
$a Walk, Jona $u Department of Internal Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands
700    1_
$a Vermeer, Cees $u Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
700    1_
$a Bílková, Simona $u Department of Internal Medicine, University Hospital of Pilsen, Pilsen, Czech Republic
700    1_
$a Janssen, Rob $u Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands
700    1_
$a Mayer, Otto $u Department of Internal Medicine, University Hospital of Pilsen, Pilsen, Czech Republic
773    0_
$w MED00005677 $t International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases $x 1878-3511 $g Roč. 125, č. - (2022), s. 275-277
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36511328 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20230131151542 $b ABA008
999    __
$a ok $b bmc $g 1891187 $s 1183617
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2022 $b 125 $c - $d 275-277 $e 20221028 $i 1878-3511 $m International journal of infectious diseases $n Int J Infect Dis $x MED00005677
LZP    __
$a Pubmed-20230120

Find record

Citation metrics

Archiving options