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Gender, age at onset, and duration of being ill as predictors for the long-term course and outcome of schizophrenia: an international multicenter study
KN. Fountoulakis, E. Dragioti, AT. Theofilidis, T. Wiklund, X. Atmatzidis, I. Nimatoudis, E. Thys, M. Wampers, L. Hranov, T. Hristova, D. Aptalidis, R. Milev, F. Iftene, F. Spaniel, P. Knytl, P. Furstova, T. From, H. Karlsson, M. Walta, RKR....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu multicentrická studie, časopisecké články
NLK
ProQuest Central
od 2012-06-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2012-06-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2012-06-01 do Před 1 rokem
- MeSH
- Diagnostický a statistický manuál mentálních poruch MeSH
- lidé MeSH
- schizofrenie * diagnóza epidemiologie MeSH
- věk při počátku nemoci MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: The aim of the current study was to explore the effect of gender, age at onset, and duration on the long-term course of schizophrenia. METHODS: Twenty-nine centers from 25 countries representing all continents participated in the study that included 2358 patients aged 37.21 ± 11.87 years with a DSM-IV or DSM-5 diagnosis of schizophrenia; the Positive and Negative Syndrome Scale as well as relevant clinicodemographic data were gathered. Analysis of variance and analysis of covariance were used, and the methodology corrected for the presence of potentially confounding effects. RESULTS: There was a 3-year later age at onset for females (P < .001) and lower rates of negative symptoms (P < .01) and higher depression/anxiety measures (P < .05) at some stages. The age at onset manifested a distribution with a single peak for both genders with a tendency of patients with younger onset having slower advancement through illness stages (P = .001). No significant effects were found concerning duration of illness. DISCUSSION: Our results confirmed a later onset and a possibly more benign course and outcome in females. Age at onset manifested a single peak in both genders, and surprisingly, earlier onset was related to a slower progression of the illness. No effect of duration has been detected. These results are partially in accord with the literature, but they also differ as a consequence of the different starting point of our methodology (a novel staging model), which in our opinion precluded the impact of confounding effects. Future research should focus on the therapeutic policy and implications of these results in more representative samples.
2nd Department of Psychiatry National and Kapodistrian University of Athens Athens Greece
Antwerp Health Law and Ethics Chair AHLEC University Antwerpen Belgium
Clinical Department of Neurology Clinical Centre of Montenegro Podgorica Montenegro
Clinical Department of Psychiatry Clinical Centre of Montenegro Podgorica Montenegro
Department for Psychosis Treatment Vilnius Mental Health Center Vilnius Lithuania
Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Clinic of Psychiatric Faculty of Medicine Vilnius University Vilnius Lithuania
Department of Neurosciences Katholieke Universiteit Leuven Leuven Belgium
Department of Psychiatry and Mental Health Santa Maria University Hospital Lisbon Portugal
Department of Psychiatry and Mental Health University of Cape Town Cape Town South Africa
Department of Psychiatry and Narcology Riga Stradins University Riga Latvia
Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria
Department of Psychiatry and Psychotherapy Semmelweis University Budapest Hungary
Department of Psychiatry College of Medicine University of Ibadan Ibadan Nigeria
Department of Psychiatry Lokmanya Tilak Municipal Medical College Mumbai India
Department of Psychiatry Queen's University Providence Care Hospital Kingston Ontario Canada
Department of Psychiatry Royal College of Surgeons in Ireland Beaumont Hospital Dublin Ireland
Department of Psychiatry Ruhr University Bochum Bochum Germany
Department of Psychiatry Sainte Marguerite University Hospital Marseille France
Department of Psychiatry School of Medicine University of Montenegro Podgorica Montenegro
Department of Psychiatry University of Florida Gainesville Florida USA
Department of Psychiatry University of Melbourne Parkville Victoria Australia
Department of Psychiatry University of Turku Turku Finland
Department of Psychosocial Rehabilitation Vilnius Mental Health Center Vilnius Lithuania
Faculty of Medicine Medical University Sofia Bulgaria
Institute of Mental Health Belgrade Serbia
Institute of Mental Health School of Medicine University of Belgrade Belgrade Serbia
National Institute of Mental Health Klecany Czech Republic
Nyírő Gyula Hospital Budapest Hungary
Orygen The National Centre of Excellence in Youth Mental Health Parkville Victoria Australia
Psychiatry Department Diskapi Yildirim Beyazit Training and Research Hospital Ankara Turkey
Serbian Academy of Sciences and Arts Belgrade Serbia
Timone Institute of Neuroscience Marseille France
University of Medicine and Pharmacy of Târgu Mureş Târgu Mureș Romania
University of Medicine and Pharmacy of Timisoara Timisoara Romania
University Psychiatric Center Katholieke Universiteit Leuven Kortenberg Belgium
Citace poskytuje Crossref.org
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