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Comparison of rhinitis treatments using MASK-air® data and considering the minimal important difference
B. Sousa-Pinto, HJ. Schünemann, A. Sá-Sousa, RJ. Vieira, R. Amaral, JM. Anto, L. Klimek, W. Czarlewski, J. Mullol, O. Pfaar, A. Bedbrook, L. Brussino, V. Kvedariene, D. Larenas-Linnemann, Y. Okamoto, MT. Ventura, I. Agache, IJ. Ansotegui, KC....
Jazyk angličtina Země Dánsko
Typ dokumentu časopisecké články
PubMed
35567393
DOI
10.1111/all.15371
Knihovny.cz E-zdroje
- MeSH
- alergická rýma * terapie MeSH
- desenzibilizace imunologická MeSH
- flutikason terapeutické užití MeSH
- hormony kůry nadledvin terapeutické užití MeSH
- lidé MeSH
- rinitida * farmakoterapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., "real-world data"). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) on allergy symptom control considering the minimal important difference (MID) and (iv) the effect of AIT. METHODS: We assessed the MASK-air® app data (May 2015-December 2020) by users self-reporting AR (16-90 years). We compared eight AR medication schemes on reported VAS of allergy symptoms, clustering data by the patient and controlling for confounding factors. We compared (i) allergy symptoms between patients with and without AIT and (ii) different drug classes used in co-medication. RESULTS: We analysed 269,837 days from 10,860 users. Most days (52.7%) involved medication use. Median VAS levels were significantly higher in co-medication than in monotherapy (including the fixed combination azelastine-fluticasone) schemes. In adjusted models, azelastine-fluticasone was associated with lower average VAS global allergy symptoms than all other medication schemes, while the contrary was observed for oral corticosteroids. AIT was associated with a decrease in allergy symptoms in some medication schemes. A difference larger than the MID compared to no treatment was observed for oral steroids. Azelastine-fluticasone was the drug class with the lowest chance of being used in co-medication (adjusted OR = 0.75; 95% CI = 0.71-0.80). CONCLUSION: Median VAS levels were higher in co-medication than in monotherapy. Patients with more severe symptoms report a higher treatment, which is currently not reflected in guidelines.
ALL MED Medical Research Institute Wrocław Poland
Allergy Center CUF Descobertas Hospital Lisbon Portugal
Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece
Celal Bayar University Department of Pulmonology Manisa Turkey
CIBER Epidemiología y Salud Pública Barcelona Spain
CINTESIS Center for Health Technology and Services Research University of Porto Porto Portugal
Department of Allergology Medical University of Gdańsk Gdansk Poland
Department of Allergy and Immunology Hospital Quironsalud Bizkaia Bilbao Spain
Department of Biomedical Sciences Humanitas University Pieve Emanuele Italy
Department of Clinical Immunology Wrocław Medical University Wrocław Poland
Department of Computing Science Umeå University Umeå Sweden
Department of Immunoallergology Cova da Beira University Hospital Centre Covilhã Portugal
Department of Medicine Clinical Immunology and Allergy McMaster University Hamilton ON Canada
Department of Otolaryngology Head and Neck Surgery Eye and Ear University Hospital Beirut Lebanon
Department of Otorhinolaryngology Amsterdam University Medical Centres AMC Amsterdam The Netherlands
Department of Otorhinolaryngology Chiba University Hospital Chiba Japan
Department of Otorhinolaryngology Head and Neck Surgery Semmelweis University Budapest Hungary
Department of Pulmonary Medicine and Tuberculosis University Hospital Brno Brno Czech Republic
Department of Pulmonary Medicine CHU Sart Tilman and GIGA I3 Research Group Liege Belgium
Division of Allergy Immunology University of South Florida Tampa Florida USA
Ecole Polytechnique Palaiseau IRBA Bretigny France
ENT Department Dar Al Shifa Hospital Salmiya Salmiya Kuwait
ENT Department Medical Faculty Eskisehir Osmangazi University Eskisehir Turkey
Faculty of Health Sciences University of Beira Interior Covilhã Portugal
Faculty of Medicine University of Ljubljana Ljubljana Slovenia
Fundaçao ProAR Federal University of Bahia and GARD WHO Planning Group Salvador Brazil
Fundacion Jimenez Diaz CIBERES Faculty of Medicine Autonoma University of Madrid Madrid Spain
IMSB Medical Faculty University at Cologne and ClinCompetence Cologne GmbH Cologne Germany
ISGlobal Barcelona Institute for Global Health Barcelona Spain
KYomed INNOV Montpellier France
Medical Consulting Czarlewski Levallois France
NOVA Medical School Comprehensive Health Research Centre Lisbon Portugal
Nova Southeastern University Fort Lauderdale Florida USA
Personalized Medicine Asthma and Allergy Humanitas Clinical and Research Center IRCCS Rozzano Italy
Poltava State Medical University Poltava Ukraine
RISE Health Research Network University of Porto Porto Portugal
School of Medicine University CEU San Pablo Madrid Spain
Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina
Skin and Allergy Hospital Helsinki University Hospital University of Helsinki Helsinki Finland
SOS Allergology and Clinical Immunology USL Toscana Centro Prato Italy
Transylvania University Brasov Brasov Romania
UBIAir Clinical and Experimental Lung Centre University of Beira Interior Covilhã Portugal
Universitat Pompeu Fabra Barcelona Spain
University Clinic of Respiratory and Allergic Diseases Golnick Slovenia
University Hospital Montpellier Montpellier France
University of Bari Medical School Unit of Geriatric Immunoallergology Bari Italy
Citace poskytuje Crossref.org
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