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Characteristics of subjective cognitive decline associated with amyloid positivity
O. Janssen, WJ. Jansen, SJB. Vos, M. Boada, L. Parnetti, T. Gabryelewicz, T. Fladby, JL. Molinuevo, S. Villeneuve, J. Hort, S. Epelbaum, A. Lleó, S. Engelborghs, WM. van der Flier, S. Landau, J. Popp, A. Wallin, P. Scheltens, MO. Rikkert, PJ....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
U01 AG024904
NIA NIH HHS - United States
NIH HHS - United States
PubMed
34877782
DOI
10.1002/alz.12512
Knihovny.cz E-zdroje
- MeSH
- amyloid MeSH
- amyloidogenní proteiny MeSH
- amyloidóza * MeSH
- apolipoprotein E4 genetika MeSH
- biologické markery MeSH
- kognitivní dysfunkce * genetika psychologie MeSH
- lidé MeSH
- mozek metabolismus MeSH
- pozitronová emisní tomografie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
INTRODUCTION: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. METHODS: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. RESULTS: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. DISCUSSION: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
Carol DAVILA University of Medicine and Pharmacy Bucharest Romania
Centre for Studies on Prevention of Alzheimer's Disease Centre Montreal Quebec Canada
Clinical Memory Research Unit Department of Clinical Sciences Malmö Lund University Lund Sweden
CSIRO Health and Biosecurity Parkville Victoria Australia
Department of Clinical Sciences Malmö Clinical Memory Research Unit Lund University Lund Sweden
Department of Geriatric Psychiatry Psychiatric University Hospital Zürich Switzerland
Department of Molecular Imaging and Therapy Austin Health Melbourne Australia
Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden
Department of Neurodegenerative Diseases and Psychiatry University Hospital Bonn Bonn Germany
Department of Neurology Akershus University Hospital Lorenskog Norway
Department of Psychiatry University of Cologne Cologne Germany
Department of Psychiatry University of Pittsburgh Pittsburgh USA
Functional Neuroimaging Group Department of Radiology University Hospital Bonn Bonn Germany
Helen Wills Neuroscience Institute University of California Berkeley California USA
Institut National de la Sant et de la Recherche M dicale Caen France
Institute of Clinical Medicine Neurology University of Eastern Finland Kuopio Finland
Institute of Clinical Medicine University of Oslo Oslo Norway
International Clinical Research Center St Anne's University Hospital Brno Czech Republic
Kingston The University of Rhode Island Rhode Island USA
Klinik für Psychiatrie und Psychotherapie Charité Universitätsmedizin Berlin CBF Berlin Deutschland
Neurology Department Hospital de Sant Pau Barcelona Spain
Old Age Psychiatry University Hospital of Lausanne Lausanne Switzerland
Vrije Universiteit Brussel Brussels and University of Antwerp Antwerp Belgium
Citace poskytuje Crossref.org
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- $a Characteristics of subjective cognitive decline associated with amyloid positivity / $c O. Janssen, WJ. Jansen, SJB. Vos, M. Boada, L. Parnetti, T. Gabryelewicz, T. Fladby, JL. Molinuevo, S. Villeneuve, J. Hort, S. Epelbaum, A. Lleó, S. Engelborghs, WM. van der Flier, S. Landau, J. Popp, A. Wallin, P. Scheltens, MO. Rikkert, PJ. Snyder, C. Rowe, G. Chételat, A. Ruíz, M. Marquié, E. Chipi, S. Wolfsgruber, M. Heneka, H. Boecker, O. Peters, J. Jarholm, L. Rami, A. Tort-Merino, AP. Binette, J. Poirier, P. Rosa-Neto, J. Cerman, B. Dubois, M. Teichmann, D. Alcolea, J. Fortea, MB. Sánchez-Saudinós, J. Ebenau, C. Pocnet, M. Eckerström, L. Thompson, V. Villemagne, R. Buckley, S. Burnham, M. Delarue, Y. Freund-Levi, ÅK. Wallin, I. Ramakers, M. Tsolaki, H. Soininen, H. Hampel, L. Spiru, Alzheimer's Disease Neuroimaging Initiative, FACEHBI study group, PREVENT-AD research group, B. Tijms, R. Ossenkoppele, FRJ. Verhey, F. Jessen, PJ. Visser
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