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Osteoporosis and Bone Marrow Adipose Tissue
KM. Beekman, G. Duque, A. Corsi, M. Tencerova, PH. Bisschop, J. Paccou
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
- MeSH
- kostní denzita MeSH
- kostní dřeň * diagnostické zobrazování MeSH
- lidé MeSH
- lipidy MeSH
- magnetická rezonanční tomografie metody MeSH
- osteoporóza * diagnostické zobrazování patologie MeSH
- tuková tkáň diagnostické zobrazování patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
PURPOSE OF REVIEW: This review focuses on the recent findings regarding bone marrow adipose tissue (BMAT) concerning bone health. We summarize the variations in BMAT in relation to age, sex, and skeletal sites, and provide an update on noninvasive imaging techniques to quantify human BMAT. Next, we discuss the role of BMAT in patients with osteoporosis and interventions that affect BMAT. RECENT FINDINGS: There are wide individual variations with region-specific fluctuation and age- and gender-specific differences in BMAT content and composition. The Bone Marrow Adiposity Society (BMAS) recommendations aim to standardize imaging protocols to increase comparability across studies and sites. Water-fat imaging (WFI) seems an accurate and efficient alternative for spectroscopy (1H-MRS). Most studies indicate that greater BMAT is associated with lower bone mineral density (BMD) and a higher prevalence of vertebral fractures. The proton density fat fraction (PDFF) and changes in lipid composition have been associated with an increased risk of fractures independently of BMD. Therefore, PDFF and lipid composition could potentially be future imaging biomarkers for assessing fracture risk. Evidence of the inhibitory effect of osteoporosis treatments on BMAT is still limited to a few randomized controlled trials. Moreover, results from the FRAME biopsy sub-study highlight contradictory findings on the effect of the sclerostin antibody romosozumab on BMAT. Further understanding of the role(s) of BMAT will provide insight into the pathogenesis of osteoporosis and may lead to targeted preventive and therapeutic strategies.
Department of Endocrinology Amsterdam UMC University of Amsterdam Amsterdam The Netherlands
Department of Molecular Medicine Sapienza University of Rome Rome Italy
Department of Rheumatology MABLaB ULR 4490 CHU Lille University Lille Lille France
Citace poskytuje Crossref.org
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