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Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients
TW. Georgi, D. Stoevesandt, L. Kurch, JM. Bartelt, D. Hasenclever, H. Dittmann, J. Ferda, P. Francis, C. Franzius, C. Furth, D. Gräfe, A. Gussew, M. Hüllner, LJ. Menezes, M. Mustafa, L. Stegger, L. Umutlu, K. Zöphel, P. Zucchetta, D. Körholz, O....
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1964 to 1 year ago
Open Access Digital Library
from 1964-01-01 to 6 months ago
Medline Complete (EBSCOhost)
from 1960-01-01
- MeSH
- Whole Body Imaging methods MeSH
- Diffusion Magnetic Resonance Imaging methods MeSH
- Child MeSH
- Fluorodeoxyglucose F18 MeSH
- Hodgkin Disease * diagnostic imaging pathology MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Bone Diseases * MeSH
- Positron Emission Tomography Computed Tomography MeSH
- Positron-Emission Tomography methods MeSH
- Workflow MeSH
- Radiopharmaceuticals MeSH
- Neoplasm Staging MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
18F-FDG PET/MRI might be the diagnostic method of choice for Hodgkin lymphoma patients, as it combines significant metabolic information from PET with excellent soft-tissue contrast from MRI and avoids radiation exposure from CT. However, a major issue is longer examination times than for PET/CT, especially for younger children needing anesthesia. Thus, a targeted selection of suitable whole-body MRI sequences is important to optimize the PET/MRI workflow. Methods: The initial PET/MRI scans of 84 EuroNet-PHL-C2 study patients from 13 international PET centers were evaluated. In each available MRI sequence, 5 PET-positive lymph nodes were assessed. If extranodal involvement occurred, 2 splenic lesions, 2 skeletal lesions, and 2 lung lesions were also assessed. A detection rate was calculated dividing the number of visible, anatomically assignable, and measurable lesions in the respective MRI sequence by the total number of lesions. Results: Relaxation time-weighted (T2w) transverse sequences with fat saturation (fs) yielded the best result, with detection rates of 95% for nodal lesions, 62% for splenic lesions, 94% for skeletal lesions, and 83% for lung lesions, followed by T2w transverse sequences without fs (86%, 49%, 16%, and 59%, respectively) and longitudinal relaxation time-weighted contrast-enhanced transverse sequences with fs (74%, 35%, 57%, and 55%, respectively). Conclusion: T2w transverse sequences with fs yielded the highest detection rates and are well suited for accurate whole-body PET/MRI in lymphoma patients. There is no evidence to recommend the use of contrast agents.
Department of Imaging University Hospital Pilsen Pilsen Czech Republic
Department of Nuclear Medicine Royal Children's Hospital Melbourne Victoria Australia
Department of Nuclear Medicine University Hospital Muenster Muenster Germany
Department of Nuclear Medicine University Hospital Zurich University of Zurich Zurich Switzerland
Department of Nuclear Medicine University of Leipzig Leipzig Germany
Department of Pediatric Oncology Justus Liebig University Giessen Germany
Department of Radiology University of Halle Halle Saale Germany
Institute for Medical Informatics Statistics and Epidemiology University of Leipzig Leipzig Germany
Medical Faculty Martin Luther University of Halle Wittenberg Halle Saale Germany
Nuclear Medicine Unit Department of Medicine Padova University Hospital Padova Italy
Paediatric Radiology Department of Radiology University of Leipzig Leipzig Germany
UCL Institute of Nuclear Medicine University College London Hospitals London United Kingdom
References provided by Crossref.org
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