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Photodynamic effect of TPP encapsulated in polystyrene nanoparticles toward multi-resistant pathogenic bacterial strains: AFM evaluation
Z. Malá, L. Žárská, L. Malina, K. Langová, R. Večeřová, M. Kolář, P. Henke, J. Mosinger, H. Kolářová
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-12-01
PubMed Central
od 2011
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od 2011
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od 2011-01-01
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od 2011-01-01
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od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01
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od 2011
- MeSH
- Bacteria účinky léků účinky záření MeSH
- fotochemické procesy * MeSH
- fotochemoterapie metody MeSH
- mikroskopie atomárních sil MeSH
- nanočástice * chemie MeSH
- polystyreny * chemie MeSH
- porfyriny aplikace a dávkování chemie MeSH
- příprava léků * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Photodynamic inactivation (PDI) is a promising approach for the efficient killing of pathogenic microbes. In this study, the photodynamic effect of sulfonated polystyrene nanoparticles with encapsulated hydrophobic 5,10,15,20-tetraphenylporphyrin (TPP-NP) photosensitizers on Gram-positive (including multi-resistant) and Gram-negative bacterial strains was investigated. The cell viability was determined by the colony forming unit method. The results showed no dark cytotoxicity but high phototoxicity within the tested conditions. Gram-positive bacteria were more sensitive to TPP-NPs than Gram-negative bacteria. Atomic force microscopy was used to detect changes in the morphological properties of bacteria before and after the PDI treatment.
Citace poskytuje Crossref.org
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- $a Photodynamic inactivation (PDI) is a promising approach for the efficient killing of pathogenic microbes. In this study, the photodynamic effect of sulfonated polystyrene nanoparticles with encapsulated hydrophobic 5,10,15,20-tetraphenylporphyrin (TPP-NP) photosensitizers on Gram-positive (including multi-resistant) and Gram-negative bacterial strains was investigated. The cell viability was determined by the colony forming unit method. The results showed no dark cytotoxicity but high phototoxicity within the tested conditions. Gram-positive bacteria were more sensitive to TPP-NPs than Gram-negative bacteria. Atomic force microscopy was used to detect changes in the morphological properties of bacteria before and after the PDI treatment.
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