Distribution of SMI-32-immunoreactive neurons in the central auditory system of the rat
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- analýza rozptylu MeSH
- colliculus inferior cytologie metabolismus MeSH
- imunohistochemie MeSH
- krysa rodu Rattus MeSH
- metathalamus cytologie metabolismus MeSH
- mikroskopie MeSH
- monoklonální protilátky metabolismus MeSH
- neurofilamentové proteiny metabolismus MeSH
- neurony aferentní metabolismus MeSH
- nucleus cochlearis cytologie metabolismus MeSH
- potkani Long-Evans MeSH
- přední mozek cytologie metabolismus MeSH
- sluchová dráha cytologie MeSH
- sluchové korové centrum cytologie metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- monoklonální protilátky MeSH
- neurofilamentové proteiny MeSH
SMI-32 antibody recognizes a non-phosphorylated epitope of neurofilament proteins, which are thought to be necessary for the maintenance of large neurons with highly myelinated processes. We investigated the distribution and quantity of SMI-32-immunoreactive(-ir) neurons in individual parts of the rat auditory system. SMI-32-ir neurons were present in all auditory structures; however, in most regions they constituted only a minority of all neurons (10-30%). In the cochlear nuclei, a higher occurrence of SMI-32-ir neurons was found in the ventral cochlear nucleus. Within the superior olivary complex, SMI-32-ir cells were particularly abundant in the medial nucleus of the trapezoid body (MNTB), the only auditory region where SMI-32-ir neurons constituted an absolute majority of all neurons. In the inferior colliculus, a region with the highest total number of neurons among the rat auditory subcortical structures, the percentage of SMI-32-ir cells was, in contrast to the MNTB, very low. In the medial geniculate body, SMI-32-ir neurons were prevalent in the ventral division. At the cortical level, SMI-32-ir neurons were found mainly in layers III, V and VI. Within the auditory cortex, it was possible to distinguish the Te1, Te2 and Te3 areas on the basis of the variable numerical density and volumes of SMI-32-ir neurons, especially when the pyramidal cells of layer V were taken into account. SMI-32-ir neurons apparently form a representative subpopulation of neurons in all parts of the rat central auditory system and may belong to both the inhibitory and excitatory systems, depending on the particular brain region.
Citace poskytuje Crossref.org
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Immunocytochemical profiles of inferior colliculus neurons in the rat and their changes with aging
