• Something wrong with this record ?

Role of lymphadenectomy during primary surgery for kidney cancer

K. Bekku, T. Kawada, T. Yanagisawa, PI. Karakiewicz, SF. Shariat

. 2023 ; 33 (4) : 294-301. [pub] 20230410

Language English Country United States

Document type Review, Journal Article

Persistent link   https://www.medvik.cz/link/bmc23010936

PURPOSE OF REVIEW: Lymph node dissection (LND) during radical nephrectomy (RN) for renal cell carcinoma (RCC) is not considered as a standard. The emergence of robot-assisted surgery and effective immune checkpoint inhibitors (ICI) in recent years may change this and lymph node (LN) staging has become easier and has a clinical impact. In this review, we aimed to reconsider the role of LND today. RECENT FINDINGS: Although the extent of LND has still not been well established, removal of more LN seems to provide better oncologic outcomes for a select group of patients with high-risk factors such as clinical T3-4. Adjuvant therapy using pembrolizumab has been shown to improve disease free survival if complete resection of metastatic lesions as well as the primary site is obtained in combination. Robot assisted RN for localized RCC has been widespread and the studies regarding LND for RCC has been recently appeared. SUMMARY: The staging and surgical benefits and its extent of LND during RN for RCC remains unclear, but it is becoming increasingly important. Technologies that allow an easier LND and adjuvant ICI that improve survival in LN-positive patients are engaging the role of LND, a procedure that was needed, but almost never done, is now indicated sometimes. Now, the goal is to identify the clinical and molecular imaging tools that can help identify with sufficient accuracy who needs a LND and which LNs to remove in a targeted personalized approach.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23010936
003      
CZ-PrNML
005      
20230801132714.0
007      
ta
008      
230718s2023 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1097/MOU.0000000000001095 $2 doi
035    __
$a (PubMed)37014778
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Bekku, Kensuke $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna $u Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
245    10
$a Role of lymphadenectomy during primary surgery for kidney cancer / $c K. Bekku, T. Kawada, T. Yanagisawa, PI. Karakiewicz, SF. Shariat
520    9_
$a PURPOSE OF REVIEW: Lymph node dissection (LND) during radical nephrectomy (RN) for renal cell carcinoma (RCC) is not considered as a standard. The emergence of robot-assisted surgery and effective immune checkpoint inhibitors (ICI) in recent years may change this and lymph node (LN) staging has become easier and has a clinical impact. In this review, we aimed to reconsider the role of LND today. RECENT FINDINGS: Although the extent of LND has still not been well established, removal of more LN seems to provide better oncologic outcomes for a select group of patients with high-risk factors such as clinical T3-4. Adjuvant therapy using pembrolizumab has been shown to improve disease free survival if complete resection of metastatic lesions as well as the primary site is obtained in combination. Robot assisted RN for localized RCC has been widespread and the studies regarding LND for RCC has been recently appeared. SUMMARY: The staging and surgical benefits and its extent of LND during RN for RCC remains unclear, but it is becoming increasingly important. Technologies that allow an easier LND and adjuvant ICI that improve survival in LN-positive patients are engaging the role of LND, a procedure that was needed, but almost never done, is now indicated sometimes. Now, the goal is to identify the clinical and molecular imaging tools that can help identify with sufficient accuracy who needs a LND and which LNs to remove in a targeted personalized approach.
650    _2
$a lidé $7 D006801
650    12
$a karcinom z renálních buněk $x patologie $7 D002292
650    _2
$a staging nádorů $7 D009367
650    12
$a nádory ledvin $x patologie $7 D007680
650    _2
$a lymfadenektomie $x metody $7 D008197
650    _2
$a lymfatické uzliny $x chirurgie $x patologie $7 D008198
655    _2
$a přehledy $7 D016454
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kawada, Tatsushi $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna $u Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
700    1_
$a Yanagisawa, Takafumi $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna $u Department of Urology, The Jikei University School of Medicine, Tokyo, Japan
700    1_
$a Karakiewicz, Pierre I $u Cancer Prognostic and Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Canada
700    1_
$a Shariat, Shahrokh F $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna $u Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia $u Division of Urology, Department of Special Surgery, The University of Jordan, Amman, Jordan $u Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas $u Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic $u Department of Urology, Weill Cornell Medical College, New York, New York, USA $u Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria
773    0_
$w MED00001296 $t Current opinion in urology $x 1473-6586 $g Roč. 33, č. 4 (2023), s. 294-301
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37014778 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230718 $b ABA008
991    __
$a 20230801132711 $b ABA008
999    __
$a ok $b bmc $g 1963384 $s 1197201
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 33 $c 4 $d 294-301 $e 20230410 $i 1473-6586 $m Current opinion in urology $n Curr Opin Urol $x MED00001296
LZP    __
$a Pubmed-20230718

Find record

Citation metrics

Archiving options