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Heart failure treated with low-dose milrinone in a full-term newborn
Šebková S., Tomek V., Zemanová P., Janota J.
Language English Country Czech Republic
Document type Case Reports
NLK
Directory of Open Access Journals
from 2012
Medline Complete (EBSCOhost)
from 2012-01-01
- MeSH
- Phosphodiesterase 3 Inhibitors administration & dosage MeSH
- Cardiotonic Agents administration & dosage MeSH
- Humans MeSH
- Milrinone administration & dosage MeSH
- Infant, Newborn MeSH
- Heart Failure drug therapy complications MeSH
- Persistent Fetal Circulation Syndrome drug therapy complications MeSH
- Vasodilator Agents administration & dosage MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
A term newborn with a hypocontractile myocardium complicating persistent pulmonary hypertension of the newborn was successfully treated with a low-dose phosphodiesterase III inhibitor milrinone. Echocardiography diagnosed heart failure with a left ventricular ejection fraction of 35% and a left ventricular shortening fraction of 18% and severe persistent pulmonary hypertension of the newborn with oxygenation index of 28. Milrinone was started at an initial dose of 50 mcg/kg, followed by continuous infusion of 0.20 mcg/kg/min. With lowdose milrinone oxygenation index decreased to 3 within 6 hours, left ventricular ejection fraction and left ventricular shortening fraction increased to 57%, and 30%, respectively. Low doses of milrinone might be promising in the treatment of heart failure and persistent pulmonary hypertension of the newborn in term newborns.
Department of Neonatology Thomayer Hospital Prague
Department of Neonatology Thomayer Hospital Prague Czech Republic
Institute of Pathological Physiology 1st Faculty of Medicine Charles University Prague Prag
Kardiocentrum and Cardiovascular Research Centre University Hospital Motol Prague
References provided by Crossref.org
Literatura
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- $a A term newborn with a hypocontractile myocardium complicating persistent pulmonary hypertension of the newborn was successfully treated with a low-dose phosphodiesterase III inhibitor milrinone. Echocardiography diagnosed heart failure with a left ventricular ejection fraction of 35% and a left ventricular shortening fraction of 18% and severe persistent pulmonary hypertension of the newborn with oxygenation index of 28. Milrinone was started at an initial dose of 50 mcg/kg, followed by continuous infusion of 0.20 mcg/kg/min. With lowdose milrinone oxygenation index decreased to 3 within 6 hours, left ventricular ejection fraction and left ventricular shortening fraction increased to 57%, and 30%, respectively. Low doses of milrinone might be promising in the treatment of heart failure and persistent pulmonary hypertension of the newborn in term newborns.
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