A term newborn with a hypocontractile myocardium complicating persistent pulmonary hypertension of the newborn was successfully treated with a low-dose phosphodiesterase III inhibitor milrinone. Echocardiography diagnosed heart failure with a left ventricular ejection fraction of 35% and a left ventricular shortening fraction of 18% and severe persistent pulmonary hypertension of the newborn with oxygenation index of 28. Milrinone was started at an initial dose of 50 mcg/kg, followed by continuous infusion of 0.20 mcg/kg/min. With lowdose milrinone oxygenation index decreased to 3 within 6 hours, left ventricular ejection fraction and left ventricular shortening fraction increased to 57%, and 30%, respectively. Low doses of milrinone might be promising in the treatment of heart failure and persistent pulmonary hypertension of the newborn in term newborns.
- MeSH
- inhibitory fosfodiesterasy 3 aplikace a dávkování MeSH
- kardiotonika aplikace a dávkování MeSH
- lidé MeSH
- milrinon aplikace a dávkování MeSH
- novorozenec MeSH
- srdeční selhání farmakoterapie komplikace MeSH
- syndrom přetrvávajícího fetálního oběhu farmakoterapie komplikace MeSH
- vazodilatancia aplikace a dávkování MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
