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Flavonoids attenuate cancer metabolism by modulating Lipid metabolism, amino acids, ketone bodies and redox state mediated by Nrf2
M. Samec, A. Mazurakova, V. Lucansky, L. Koklesova, R. Pecova, M. Pec, O. Golubnitschaja, RK. Al-Ishaq, M. Caprnda, L. Gaspar, R. Prosecky, K. Gazdikova, M. Adamek, D. Büsselberg, P. Kruzliak, P. Kubatka
Language English Country Netherlands
Document type Journal Article, Review
- MeSH
- Amino Acids * MeSH
- NF-E2-Related Factor 2 metabolism MeSH
- Flavonoids pharmacology MeSH
- Ketone Bodies metabolism MeSH
- Humans MeSH
- Lipid Metabolism MeSH
- Cell Transformation, Neoplastic metabolism MeSH
- Neoplasms * drug therapy metabolism MeSH
- Oxidation-Reduction MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Metabolic reprogramming of cancer cells is a common hallmark of malignant transformation. The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well-studied phenomenon known as the Warburg effect. Importantly, metabolic transformation of cancer cells also involves alterations in signaling cascades contributing to lipid metabolism, amino acid flux and synthesis, and utilization of ketone bodies. Also, redox regulation interacts with metabolic reprogramming during malignant transformation. Flavonoids, widely distributed phytochemicals in plants, exert various beneficial effects on human health through modulating molecular cascades altered in the pathological cancer phenotype. Recent evidence has identified numerous flavonoids as modulators of critical components of cancer metabolism and associated pathways interacting with metabolic cascades such as redox balance. Flavonoids affect lipid metabolism by regulating fatty acid synthase, redox balance by modulating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activity, or amino acid flux and synthesis by phosphoglycerate mutase 1. Here, we discuss recent preclinical evidence evaluating the impact of flavonoids on cancer metabolism, focusing on lipid and amino acid metabolic cascades, redox balance, and ketone bodies.
Department of Anatomy Comenius University in Bratislava Martin Slovakia
Department of General Medicine Faculty of Medicine Slovak Medical University Bratislava Slovakia
Department of Thoracic Surgery Medical University of Silesia Katowice Poland
Faculty of Health Sciences University of Ss Cyril and Methodius in Trnava Trnava Slovakia
Weill Cornell Medicine Qatar Education City Qatar Foundation Doha Qatar
References provided by Crossref.org
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- $a Samec, Marek $u Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
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- $a Flavonoids attenuate cancer metabolism by modulating Lipid metabolism, amino acids, ketone bodies and redox state mediated by Nrf2 / $c M. Samec, A. Mazurakova, V. Lucansky, L. Koklesova, R. Pecova, M. Pec, O. Golubnitschaja, RK. Al-Ishaq, M. Caprnda, L. Gaspar, R. Prosecky, K. Gazdikova, M. Adamek, D. Büsselberg, P. Kruzliak, P. Kubatka
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- $a Metabolic reprogramming of cancer cells is a common hallmark of malignant transformation. The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well-studied phenomenon known as the Warburg effect. Importantly, metabolic transformation of cancer cells also involves alterations in signaling cascades contributing to lipid metabolism, amino acid flux and synthesis, and utilization of ketone bodies. Also, redox regulation interacts with metabolic reprogramming during malignant transformation. Flavonoids, widely distributed phytochemicals in plants, exert various beneficial effects on human health through modulating molecular cascades altered in the pathological cancer phenotype. Recent evidence has identified numerous flavonoids as modulators of critical components of cancer metabolism and associated pathways interacting with metabolic cascades such as redox balance. Flavonoids affect lipid metabolism by regulating fatty acid synthase, redox balance by modulating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activity, or amino acid flux and synthesis by phosphoglycerate mutase 1. Here, we discuss recent preclinical evidence evaluating the impact of flavonoids on cancer metabolism, focusing on lipid and amino acid metabolic cascades, redox balance, and ketone bodies.
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- $a Mazurakova, Alena $u Department of Anatomy, Comenius University in Bratislava, Martin, Slovakia
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- $a Pecova, Renata $u Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia
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- $a Gazdikova, Katarina $u Department of Nutrition, Faculty of Nursing and Professional Health Studies, Slovak Medical University, Bratislava, Slovakia; Department of General Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia. Electronic address: katarina.gazdikova@szu.sk
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- $a Kruzliak, Peter $u 2(nd) Department of Surgery, Faculty of Medicine, Masaryk University and St. Anne's University Hospital, Brno, Czech Republic. Electronic address: peter.kruzliak@fnusa.cz
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- $a Kubatka, Peter $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. Electronic address: peter.kubatka@uniba.sk
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