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Microdialysis as a tool for antibiotic assessment in patients with diabetic foot: a review

V. Fejfarová, R. Jarošíková, J. Polák, B. Sommerová, J. Husáková, V. Wosková, M. Dubský, P. Tůma

. 2023 ; 14 (-) : 1141086. [pub] 20230417

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc23011760

Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy can be easily verified using triplex ultrasound, ankle-brachial/toe-brachial index examination, or transcutaneous oxygen pressure. However, the success of infection treatment is difficult to establish in patients with diabetic foot. Intravenous systemic antibiotics are recommended for the treatment of infectious complications in patients with moderate or serious stages of infection. Antibiotic therapy should be initiated promptly and aggressively to achieve sufficient serum and peripheral antibiotic concentrations. Antibiotic serum levels are easily evaluated by pharmacokinetic assessment. However, antibiotic concentrations in peripheral tissues, especially in diabetic foot, are not routinely detectable. This review describes microdialysis techniques that have shown promise in determining antibiotic levels in the surroundings of diabetic foot lesions.

Citace poskytuje Crossref.org

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$a Jarošíková, Radka $u Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czechia $u Second Faculty of Medicine, Charles University, Prague, Czechia
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$a Polák, Jan $u Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czechia
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$a Sommerová, Blanka $u Department of Hygiene, Third Faculty of Medicine, Charles University, Prague, Czechia
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