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Evaluation of alfaxalone's anti-inflammatory and antinociceptive effects in broiler chicks

Amjed Najem Alatroshi, Ahmed Salah Naser

. 2023 ; 92 (3) : 208-216. [pub] 20230901

Language English Country Czech Republic

Document type Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc23013698

Background: Progesterone is the source of the steroid general anesthetic Alfaxalone, which became commercially available in the 1970s when combined with alfadolone, another steroid anesthetic.Objective: the goal of the present research was to discover and assess the sub-anesthetic effects of Alfaxalone: the antinociceptive and anti-inflammatory properties in broiler chicks. Methods: One hundred and three Ross broiler chicks (80-100 g, 7-8 days old) were used. The electric stimulation test, hot water test (HWT), and formalin test were performed on broiler chicks to assess the antinociceptive and anti-inflammatory properties of Alfaxalone. The up-and-down method that described by Dixon was used to determine the median effective antinociceptive dose.Results: The median effective antinociceptive doses (ED50s) of Alfaxalone by electric stimulation test and hot water test were 0.94 and 0.65 mg/kg intraperitoneally, respectively. Alfaxalone, at doses of 1, 2, and 4 mg/kg intraperitoneally, induced an antinociceptive effect in the electric stimulation test and HWT as well as antinociceptive and anti-inflammatory effects during the formalin test in the chicks. The antinociceptive effect was displayed 15 min after treatment and the maximum effect was observed 30 min after injection.Conclusion: The results showed that Alfaxalone had antinociceptive and anti-inflammatory effects, with a stronger antinociceptive effect in the electric stimulation test than in the thermal stimulation test, which was illustrated by shorter antinociceptive time.

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$a Background: Progesterone is the source of the steroid general anesthetic Alfaxalone, which became commercially available in the 1970s when combined with alfadolone, another steroid anesthetic.Objective: the goal of the present research was to discover and assess the sub-anesthetic effects of Alfaxalone: the antinociceptive and anti-inflammatory properties in broiler chicks. Methods: One hundred and three Ross broiler chicks (80-100 g, 7-8 days old) were used. The electric stimulation test, hot water test (HWT), and formalin test were performed on broiler chicks to assess the antinociceptive and anti-inflammatory properties of Alfaxalone. The up-and-down method that described by Dixon was used to determine the median effective antinociceptive dose.Results: The median effective antinociceptive doses (ED50s) of Alfaxalone by electric stimulation test and hot water test were 0.94 and 0.65 mg/kg intraperitoneally, respectively. Alfaxalone, at doses of 1, 2, and 4 mg/kg intraperitoneally, induced an antinociceptive effect in the electric stimulation test and HWT as well as antinociceptive and anti-inflammatory effects during the formalin test in the chicks. The antinociceptive effect was displayed 15 min after treatment and the maximum effect was observed 30 min after injection.Conclusion: The results showed that Alfaxalone had antinociceptive and anti-inflammatory effects, with a stronger antinociceptive effect in the electric stimulation test than in the thermal stimulation test, which was illustrated by shorter antinociceptive time.
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