-
Je něco špatně v tomto záznamu ?
International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System
M. Lechner, Y. Takahashi, M. Turri-Zanoni, M. Ferrari, J. Liu, N. Counsell, D. Mattavelli, V. Rampinelli, W. Vermi, D. Lombardi, R. Saade, KW. Park, VH. Schartinger, A. Franchi, C. Facco, F. Sessa, S. Battocchio, TR. Fenton, FM. Vaz, P. O'Flynn,...
Status neindexováno Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 2012 do Před 1 rokem
PubMed Central
od 2012 do Před 1 rokem
PubMed
37405239
DOI
10.1055/s-0042-1750178
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucially, our understanding of its clinical presentation, course, and optimal treatment remains limited, and few advancements in improving its management have been made in the recent past. Methods We conducted an international multicenter retrospective analysis of 505 SNMM cases from 11 institutions across the United States, United Kingdom, Ireland, and continental Europe. Data on clinical presentation, diagnosis, treatment, and clinical outcomes were assessed. Results One-, three-, and five-year recurrence-free and overall survival were 61.4, 30.6, and 22.0%, and 77.6, 49.2, and 38.3%, respectively. Compared with disease confined to the nasal cavity, sinus involvement confers significantly worse survival; based on this, further stratifying the T3 stage was highly prognostic ( p < 0.001) with implications for a potential modification to the current TNM staging system. There was a statistically significant survival benefit for patients who received adjuvant radiotherapy, compared with those who underwent surgery alone (hazard ratio [HR] = 0.74, 95% confidence interval [CI]: 0.57-0.96, p = 0.021). Immune checkpoint blockade for the management of recurrent or persistent disease, with or without distant metastasis, conferred longer survival (HR = 0.50, 95% CI: 0.25-1.00, p = 0.036). Conclusions We present findings from the largest cohort of SNMM reported to date. We demonstrate the potential utility of further stratifying the T3 stage by sinus involvement and present promising data on the benefit of immune checkpoint inhibitors for recurrent, persistent, or metastatic disease with implications for future clinical trials in this field.
Cancer Research UK and UCL Cancer Trials Centre University College London London United Kingdom
Cancer Sciences Unit Faculty of Medicine University of Southampton United Kingdom
Department of Clinical Oncology The Christie NHS Foundation Trust Manchester United Kingdom
Department of ENT Barts Health NHS Trust London United Kingdom
Department of Histopathology University College London Hospitals NHS Trust London United Kingdom
Department of Oncology Johns Hopkins University School of Medicine Baltimore Maryland United States
Department of Otolaryngology Head and Neck Surgery Beaumont Hospital Dublin Ireland
Department of Otolaryngology Head and Neck Surgery Lebanese American University Beirut Lebanon
Department of Otolaryngology University of Pittsburgh Medical Center Pittsburgh United States
Department of Otorhinolaryngology Medical University of Innsbruck Innsbruck Austria
Department of Translational Research University of Pisa Pisa Italy
Disease Team Alignment Head and Neck City of Hope Medical Center Duarte California United States
Division of Dentistry University of Manchester Manchester United Kingdom
Head and Neck Centre University College London Hospitals NHS Trust London United Kingdom
Liverpool Head and Neck Centre University of Liverpool Liverpool United Kingdom
The Royal College of Surgeons in Ireland Dublin Ireland
UCL Cancer Institute University College London London United Kingdom
UCL Division of Surgery and Interventional Science University College London London United Kingdom
Unit of Pathology ASST Sette Laghi University of Insubria Varese Italy
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23015574
- 003
- CZ-PrNML
- 005
- 20231020093509.0
- 007
- ta
- 008
- 231010s2023 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1055/s-0042-1750178 $2 doi
- 035 __
- $a (PubMed)37405239
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Lechner, Matt $u UCL Cancer Institute, University College London, London, United Kingdom $u UCL Division of Surgery and Interventional Science, University College London, London, United Kingdom $u Department of ENT, Barts Health NHS Trust, London, United Kingdom
- 245 10
- $a International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System / $c M. Lechner, Y. Takahashi, M. Turri-Zanoni, M. Ferrari, J. Liu, N. Counsell, D. Mattavelli, V. Rampinelli, W. Vermi, D. Lombardi, R. Saade, KW. Park, VH. Schartinger, A. Franchi, C. Facco, F. Sessa, S. Battocchio, TR. Fenton, FM. Vaz, P. O'Flynn, D. Howard, P. Stimpson, S. Wang, SA. Hannan, S. Unadkat, J. Hughes, R. Dwivedi, CT. Forde, P. Randhawa, S. Gane, J. Joseph, PJ. Andrews, M. Dave, JC. Fleming, D. Thomson, T. Zhu, A. Teschendorff, G. Royle, C. Steele, JE. Jimenez, J. Laco, EW. Wang, C. Snyderman, PD. Lacy, R. Woods, JP. O'Neill, A. Saraswathula, RP. Kaur, T. Zhao, M. Ramanathan, GL. Gallia, NR. London, QT. Le, RB. West, ZM. Patel, JV. Nayak, PH. Hwang, M. Hermsen, J. Llorente, F. Facchetti, P. Nicolai, P. Bossi, P. Castelnuovo, A. Jay, D. Carnell, MD. Forster, DM. Bell, VJ. Lund, EY. Hanna
- 520 9_
- $a Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucially, our understanding of its clinical presentation, course, and optimal treatment remains limited, and few advancements in improving its management have been made in the recent past. Methods We conducted an international multicenter retrospective analysis of 505 SNMM cases from 11 institutions across the United States, United Kingdom, Ireland, and continental Europe. Data on clinical presentation, diagnosis, treatment, and clinical outcomes were assessed. Results One-, three-, and five-year recurrence-free and overall survival were 61.4, 30.6, and 22.0%, and 77.6, 49.2, and 38.3%, respectively. Compared with disease confined to the nasal cavity, sinus involvement confers significantly worse survival; based on this, further stratifying the T3 stage was highly prognostic ( p < 0.001) with implications for a potential modification to the current TNM staging system. There was a statistically significant survival benefit for patients who received adjuvant radiotherapy, compared with those who underwent surgery alone (hazard ratio [HR] = 0.74, 95% confidence interval [CI]: 0.57-0.96, p = 0.021). Immune checkpoint blockade for the management of recurrent or persistent disease, with or without distant metastasis, conferred longer survival (HR = 0.50, 95% CI: 0.25-1.00, p = 0.036). Conclusions We present findings from the largest cohort of SNMM reported to date. We demonstrate the potential utility of further stratifying the T3 stage by sinus involvement and present promising data on the benefit of immune checkpoint inhibitors for recurrent, persistent, or metastatic disease with implications for future clinical trials in this field.
- 590 __
- $a NEINDEXOVÁNO
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Takahashi, Yoko $u Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
- 700 1_
- $a Turri-Zanoni, Mario $u Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy
- 700 1_
- $a Ferrari, Marco $u Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padova, Padova, Italy
- 700 1_
- $a Liu, Jacklyn $u UCL Cancer Institute, University College London, London, United Kingdom
- 700 1_
- $a Counsell, Nicholas $u Cancer Research UK and UCL Cancer Trials Centre, University College London, London, United Kingdom
- 700 1_
- $a Mattavelli, Davide $u Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
- 700 1_
- $a Rampinelli, Vittorio $u Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
- 700 1_
- $a Vermi, William $u Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
- 700 1_
- $a Lombardi, Davide $u Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
- 700 1_
- $a Saade, Rami $u Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States $u Department of Otolaryngology-Head and Neck Surgery, Lebanese American University, Beirut, Lebanon
- 700 1_
- $a Park, Ki Wan $u Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, United States
- 700 1_
- $a Schartinger, Volker H $u Department of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria
- 700 1_
- $a Franchi, Alessandro $u Department of Translational Research, University of Pisa, Pisa, Italy
- 700 1_
- $a Facco, Carla $u Unit of Pathology, ASST Sette Laghi, University of Insubria, Varese, Italy
- 700 1_
- $a Sessa, Fausto $u Unit of Pathology, ASST Sette Laghi, University of Insubria, Varese, Italy
- 700 1_
- $a Battocchio, Simonetta $u Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, ASST Spedali Civili, Brescia, Italy
- 700 1_
- $a Fenton, Tim R $u Cancer Sciences Unit, Faculty of Medicine, University of Southampton, United Kingdom
- 700 1_
- $a Vaz, Francis M $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a O'Flynn, Paul $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Howard, David $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Stimpson, Paul $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Wang, Simon $u Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- 700 1_
- $a Hannan, S Alam $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Unadkat, Samit $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Hughes, Jonathan $u Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Dwivedi, Raghav $u Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Forde, Cillian T $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Randhawa, Premjit $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Gane, Simon $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Joseph, Jonathan $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Andrews, Peter J $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Dave, Manas $u Division of Dentistry, University of Manchester, Manchester, United Kingdom
- 700 1_
- $a Fleming, Jason C $u Liverpool Head & Neck Centre, University of Liverpool, Liverpool, United Kingdom
- 700 1_
- $a Thomson, David $u Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom $u Liverpool Head & Neck Centre, University of Liverpool, Liverpool, United Kingdom
- 700 1_
- $a Zhu, Tianyu $u CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, People's Republic of China
- 700 1_
- $a Teschendorff, Andrew $u CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, People's Republic of China
- 700 1_
- $a Royle, Gary $u UCL Cancer Institute, University College London, London, United Kingdom
- 700 1_
- $a Steele, Christopher $u UCL Cancer Institute, University College London, London, United Kingdom
- 700 1_
- $a Jimenez, Joaquin E $u Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, United States
- 700 1_
- $a Laco, Jan $u The Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
- 700 1_
- $a Wang, Eric W $u Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, United States $u Center for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
- 700 1_
- $a Snyderman, Carl $u Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, United States $u Center for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
- 700 1_
- $a Lacy, Peter D $u Department of Otolaryngology-Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland
- 700 1_
- $a Woods, Robbie $u Department of Otolaryngology-Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland
- 700 1_
- $a O'Neill, James P $u Department of Otolaryngology-Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland $u The Royal College of Surgeons in Ireland, Dublin, Ireland
- 700 1_
- $a Saraswathula, Anirudh $u Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, United States
- 700 1_
- $a Kaur, Raman Preet $u Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, United States
- 700 1_
- $a Zhao, Tianna $u Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
- 700 1_
- $a Ramanathan, Murugappan $u Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, United States $u Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
- 700 1_
- $a Gallia, Gary L $u Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, United States $u Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States $u Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
- 700 1_
- $a London, Nyall R $u Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, United States $u Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States $u Sinonasal and Skull Base Tumor Program-Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, United States
- 700 1_
- $a Le, Quynh-Thu $u Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California, United States
- 700 1_
- $a West, Robert B $u Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California, United States
- 700 1_
- $a Patel, Zara M $u Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, United States $1 https://orcid.org/000000032072982X
- 700 1_
- $a Nayak, Jayakar V $u Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, United States
- 700 1_
- $a Hwang, Peter H $u Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California, United States
- 700 1_
- $a Hermsen, Mario $u Department of Head and Neck Oncology, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain
- 700 1_
- $a Llorente, Jose $u Department of Head and Neck Oncology, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain
- 700 1_
- $a Facchetti, Fabio $u Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, ASST Spedali Civili, Brescia, Italy
- 700 1_
- $a Nicolai, Piero $u Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padova, Padova, Italy
- 700 1_
- $a Bossi, Paolo $u Medical Oncology, Department of Medical and Surgical Specialities, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
- 700 1_
- $a Castelnuovo, Paolo $u Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy
- 700 1_
- $a Jay, Amrita $u Department of Histopathology, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Carnell, Dawn $u Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Forster, Martin D $u UCL Cancer Institute, University College London, London, United Kingdom
- 700 1_
- $a Bell, Diana M $u Disease Team Alignment: Head and Neck, City of Hope Medical Center, Duarte, California, United States
- 700 1_
- $a Lund, Valerie J $u Royal National ENT Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, United Kingdom
- 700 1_
- $a Hanna, Ehab Y $u Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
- 773 0_
- $w MED00179152 $t Journal of neurological surgery. Part B, Skull base $x 2193-6331 $g Roč. 84, č. 4 (2023), s. 307-319
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/37405239 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20231010 $b ABA008
- 991 __
- $a 20231020093502 $b ABA008
- 999 __
- $a ok $b bmc $g 1997189 $s 1201936
- BAS __
- $a 3
- BAS __
- $a PreBMC-PubMed-not-MEDLINE
- BMC __
- $a 2023 $b 84 $c 4 $d 307-319 $e 20220710 $i 2193-6331 $m Journal of neurological surgery. Part B, Skull base $n J Neurol Surg B Skull Base $x MED00179152
- LZP __
- $a Pubmed-20231010
