• Je něco špatně v tomto záznamu ?

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project

M. Audebert, AS. Assmann, A. Azqueta, P. Babica, E. Benfenati, S. Bortoli, P. Bouwman, A. Braeuning, T. Burgdorf, X. Coumoul, K. Debizet, M. Dusinska, N. Ertych, J. Fahrer, V. Fetz, L. Le Hégarat, A. López de Cerain, HJ. Heusinkveld, K. Hogeveen,...

. 2023 ; 5 (-) : 1220998. [pub] 20230710

Status neindexováno Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc23015753

Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcinogens (NGTxCs). Genotoxic compounds induce DNA damage, which can be detected by an established in vitro and in vivo battery of genotoxicity assays. For NGTxCs, DNA is not the primary target, and the possible modes of action (MoA) of NGTxCs are much more diverse than those of genotoxic compounds, and there is no specific in vitro assay for detecting NGTxCs. Therefore, the evaluation of the carcinogenic potential is still dependent on long-term studies in rodents. This 2-year bioassay, mainly applied for testing agrochemicals and pharmaceuticals, is time-consuming, costly and requires very high numbers of animals. More importantly, its relevance for human risk assessment is questionable due to the limited predictivity for human cancer risk, especially with regard to NGTxCs. Thus, there is an urgent need for a transition to new approach methodologies (NAMs), integrating human-relevant in vitro assays and in silico tools that better exploit the current knowledge of the multiple processes involved in carcinogenesis into a modern safety assessment toolbox. Here, we describe an integrative project that aims to use a variety of novel approaches to detect the carcinogenic potential of NGTxCs based on different mechanisms and pathways involved in carcinogenesis. The aim of this project is to contribute suitable assays for the safety assessment toolbox for an efficient and improved, internationally recognized hazard assessment of NGTxCs, and ultimately to contribute to reliable mechanism-based next-generation risk assessment for chemical carcinogens.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23015753
003      
CZ-PrNML
005      
20231020093644.0
007      
ta
008      
231010s2023 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/ftox.2023.1220998 $2 doi
035    __
$a (PubMed)37492623
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Audebert, Marc $u INRAE: Toxalim, INRAE, INP-ENVT, INP-EI-Purpan, Université de Toulouse 3 Paul Sabatier, Toulouse, France
245    10
$a New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project / $c M. Audebert, AS. Assmann, A. Azqueta, P. Babica, E. Benfenati, S. Bortoli, P. Bouwman, A. Braeuning, T. Burgdorf, X. Coumoul, K. Debizet, M. Dusinska, N. Ertych, J. Fahrer, V. Fetz, L. Le Hégarat, A. López de Cerain, HJ. Heusinkveld, K. Hogeveen, MN. Jacobs, M. Luijten, G. Raitano, C. Recoules, E. Rundén-Pran, M. Saleh, I. Sovadinová, M. Stampar, L. Thibol, C. Tomkiewicz, A. Vettorazzi, B. Van de Water, N. El Yamani, B. Zegura, M. Oelgeschläger
520    9_
$a Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcinogens (NGTxCs). Genotoxic compounds induce DNA damage, which can be detected by an established in vitro and in vivo battery of genotoxicity assays. For NGTxCs, DNA is not the primary target, and the possible modes of action (MoA) of NGTxCs are much more diverse than those of genotoxic compounds, and there is no specific in vitro assay for detecting NGTxCs. Therefore, the evaluation of the carcinogenic potential is still dependent on long-term studies in rodents. This 2-year bioassay, mainly applied for testing agrochemicals and pharmaceuticals, is time-consuming, costly and requires very high numbers of animals. More importantly, its relevance for human risk assessment is questionable due to the limited predictivity for human cancer risk, especially with regard to NGTxCs. Thus, there is an urgent need for a transition to new approach methodologies (NAMs), integrating human-relevant in vitro assays and in silico tools that better exploit the current knowledge of the multiple processes involved in carcinogenesis into a modern safety assessment toolbox. Here, we describe an integrative project that aims to use a variety of novel approaches to detect the carcinogenic potential of NGTxCs based on different mechanisms and pathways involved in carcinogenesis. The aim of this project is to contribute suitable assays for the safety assessment toolbox for an efficient and improved, internationally recognized hazard assessment of NGTxCs, and ultimately to contribute to reliable mechanism-based next-generation risk assessment for chemical carcinogens.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Assmann, Ann-Sophie $u Department Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany
700    1_
$a Azqueta, Amaya $u Department of Pharmacology and Toxicology, School of Pharmacy and Nutrition, UNAV: University of Navarra, Pamplona, Spain
700    1_
$a Babica, Pavel $u RECETOX: RECETOX, Faculty of Science, Masaryk University, Brno, Czechia
700    1_
$a Benfenati, Emilio $u IRFMN: Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy
700    1_
$a Bortoli, Sylvie $u INSERM: INSERM UMR-S 1124 T3S-Université Paris Cité, Paris, France
700    1_
$a Bouwman, Peter $u UL-LACDR: Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands
700    1_
$a Braeuning, Albert $u Department Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany
700    1_
$a Burgdorf, Tanja $u Department Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany
700    1_
$a Coumoul, Xavier $u INSERM: INSERM UMR-S 1124 T3S-Université Paris Cité, Paris, France
700    1_
$a Debizet, Kloé $u INSERM: INSERM UMR-S 1124 T3S-Université Paris Cité, Paris, France
700    1_
$a Dusinska, Maria $u Health Effects Laboratory, NILU: The Climate and Environmental Research Institute, Kjeller, Norway
700    1_
$a Ertych, Norman $u Department Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany
700    1_
$a Fahrer, Jörg $u Department of Chemistry, RPTU: Division of Food Chemistry and Toxicology, Kaiserslautern, Germany
700    1_
$a Fetz, Verena $u Department Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany
700    1_
$a Le Hégarat, Ludovic $u ANSES: French Agency for Food, Environmental and Occupational Health and Safety, Fougères Laboratory, Toxicology of Contaminants Unit, Fougères, France
700    1_
$a López de Cerain, Adela $u Department of Pharmacology and Toxicology, School of Pharmacy and Nutrition, UNAV: University of Navarra, Pamplona, Spain
700    1_
$a Heusinkveld, Harm J $u RIVM: National Institute for Public Health and the Environment, Bilthoven, Netherlands
700    1_
$a Hogeveen, Kevin $u ANSES: French Agency for Food, Environmental and Occupational Health and Safety, Fougères Laboratory, Toxicology of Contaminants Unit, Fougères, France
700    1_
$a Jacobs, Miriam N $u Radiation, Chemical and Environmental Hazards, UKHSA: UK Health Security Agency, Chilton, Oxfordshire, United Kingdom
700    1_
$a Luijten, Mirjam $u RIVM: National Institute for Public Health and the Environment, Bilthoven, Netherlands
700    1_
$a Raitano, Giuseppa $u IRFMN: Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Milan, Italy
700    1_
$a Recoules, Cynthia $u INRAE: Toxalim, INRAE, INP-ENVT, INP-EI-Purpan, Université de Toulouse 3 Paul Sabatier, Toulouse, France
700    1_
$a Rundén-Pran, Elise $u Health Effects Laboratory, NILU: The Climate and Environmental Research Institute, Kjeller, Norway
700    1_
$a Saleh, Mariam $u ANSES: French Agency for Food, Environmental and Occupational Health and Safety, Fougères Laboratory, Toxicology of Contaminants Unit, Fougères, France
700    1_
$a Sovadinová, Iva $u RECETOX: RECETOX, Faculty of Science, Masaryk University, Brno, Czechia
700    1_
$a Stampar, Martina $u Department of Genetic Toxicology and Cancer Biology, NIB: National Institute of Biology, Ljubljana, Slovenia
700    1_
$a Thibol, Lea $u Department of Chemistry, RPTU: Division of Food Chemistry and Toxicology, Kaiserslautern, Germany
700    1_
$a Tomkiewicz, Céline $u INSERM: INSERM UMR-S 1124 T3S-Université Paris Cité, Paris, France
700    1_
$a Vettorazzi, Ariane $u Department of Pharmacology and Toxicology, School of Pharmacy and Nutrition, UNAV: University of Navarra, Pamplona, Spain
700    1_
$a Van de Water, Bob $u UL-LACDR: Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands
700    1_
$a El Yamani, Naouale $u Health Effects Laboratory, NILU: The Climate and Environmental Research Institute, Kjeller, Norway
700    1_
$a Zegura, Bojana $u Department of Genetic Toxicology and Cancer Biology, NIB: National Institute of Biology, Ljubljana, Slovenia
700    1_
$a Oelgeschläger, Michael $u Department Experimental Toxicology and ZEBET, German Centre for the Protection of Laboratory Animals (Bf3R) and Department Food Safety, BfR: German Federal Institute for Risk Assessment, Berlin, Germany
773    0_
$w MED00209728 $t Frontiers in toxicology $x 2673-3080 $g Roč. 5, č. - (2023), s. 1220998
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37492623 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20231010 $b ABA008
991    __
$a 20231020093637 $b ABA008
999    __
$a ok $b bmc $g 1997248 $s 1202115
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2023 $b 5 $c - $d 1220998 $e 20230710 $i 2673-3080 $m Frontiers in toxicology $n Front Toxicol $x MED00209728
LZP    __
$a Pubmed-20231010

Najít záznam

Citační ukazatele

Možnosti archivace