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Plasma-Derived Nanoclusters for Site-Specific Multimodality Photo/Magnetic Thrombus Theranostics
CH. Liu, MC. Liu, PR. Jheng, J. Yu, YJ. Fan, JW. Liang, YC. Hsiao, CW. Chiang, N. Bolouki, JW. Lee, JH. Hsieh, BW. Mansel, YT. Chen, HT. Nguyen, EY. Chuang
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
37421244
DOI
10.1002/adhm.202301504
Knihovny.cz E-zdroje
- MeSH
- fibrinolytika chemie terapeutické užití MeSH
- individualizovaná medicína MeSH
- magnetické jevy MeSH
- myši MeSH
- trombolytická terapie * MeSH
- trombóza * diagnostické zobrazování farmakoterapie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Traditional thrombolytic therapeutics for vascular blockage are affected by their limited penetration into thrombi, associated off-target side effects, and low bioavailability, leading to insufficient thrombolytic efficacy. It is hypothesized that these limitations can be overcome by the precisely controlled and targeted delivery of thrombolytic therapeutics. A theranostic platform is developed that is biocompatible, fluorescent, magnetic, and well-characterized, with multiple targeting modes. This multimodal theranostic system can be remotely visualized and magnetically guided toward thrombi, noninvasively irradiated by near-infrared (NIR) phototherapies, and remotely activated by actuated magnets for additional mechanical therapy. Magnetic guidance can also improve the penetration of nanomedicines into thrombi. In a mouse model of thrombosis, the thrombosis residues are reduced by ≈80% and with no risk of side effects or of secondary embolization. This strategy not only enables the progression of thrombolysis but also accelerates the lysis rate, thereby facilitating its prospective use in time-critical thrombolytic treatment.
Clinical Research Center Taipei Medical University Hospital Taipei 11031 Taiwan
Department of Materials Engineering Ming Chi University of Technology New Taipei City 24301 Taiwan
Department of Orthopedics Taipei Medical University Hospital Taipei 11031 Taiwan
Department of Orthopedics Taipei Medical University Taipei 11031 Taiwan
Department of Physical Electronics Faculty of Science Masaryk University Brno 60177 Czech Republic
National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu 30076 Taiwan
School of Dental Technology College of Oral Medicine Taipei Medical University Taipei 11031 Taiwan
Citace poskytuje Crossref.org
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- $a Liu, Chia-Hung $u Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan $u TMU Research Center of Urology and Kidney, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan $u Department of Urology, Shuang Ho Hospital, Taipei Medical University, 291 Zhongzheng Road, Zhonghe District, New Taipei City, 23561, Taiwan
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