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Genetic variants associated with glycemic response to treatment with dipeptidylpeptidase 4 inhibitors
A. Űrgeová, M. Javorský, L. Klimčáková, J. Židzik, J. Šalagovič, JA. Hubáček, P. Doubravová, I. Gotthardová, M. Kvapil, T. Pelikánová, I. Tkáč, AS. Yaluri
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
PubMed Central
od 2015 do Před 1 rokem
ProQuest Central
od 2000-02-01 do 2020-12-31
Health & Medicine (ProQuest)
od 2000-02-01 do 2020-12-31
PubMed
32308134
DOI
10.2217/pgs-2019-0147
Knihovny.cz E-zdroje
- MeSH
- alely MeSH
- diabetes mellitus 2. typu * farmakoterapie genetika MeSH
- inhibitory dipeptidylpeptidasy 4 * terapeutické užití MeSH
- lidé MeSH
- metformin * MeSH
- vildagliptin terapeutické užití MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Aim: We examined associations of eight SNPs in/near seven candidate genes with glycemic response to 6 month treatment with DPP4 inhibitors. Patients & methods: 206 patients with type 2 diabetes (116 men and 90 women) were treated with sitagliptin or vildagliptin (both 100 mg/day) in combination with metformin or metformin/sulphonylurea over 6 months, and the reduction in glycated hemoglobin (HbA1c) was measured. Results: Rs6923761 in GLP1R was significantly associated with a reduction in HbA1c (adjusted p = 0.006). Homozygotes for the minor A allele had smaller reduction in HbA1c by 0.4% (4 mmol/mol) than the G allele carriers (p = 0.016). Conclusion: The missense variant rs6923761 in the GLP1R gene was associated with a smaller glycemic response to 6 month gliptin therapy in diabetic patients of central European origin.
Charles University Faculty of Medicine 2 Prague Czech Republic
Faculty Hospital in Motol Department of Medicine Prague Czech Republic
Institute for Clinical and Experimental Medicine Diabetes Centre Prague Czech Republic
Institute for Clinical and Experimental Medicine Prague Czech Republic
Louis Pasteur University Hospital Košice Slovakia
Pavol Jozef Šafárik University Faculty of Medicine Košice Slovakia
Citace poskytuje Crossref.org
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