-
Je něco špatně v tomto záznamu ?
Predictors of Good Clinical Outcome After Endovascular Treatment for Acute Ischemic Stroke due to Tandem Lesion in Anterior Circulation: Results from the ASCENT Study
R. Havlíček, D. Šaňák, D. Černík, J. Neradová, N. Leško, Z. Gdovinová, M. Köcher, F. Cihlář, J. Malik, J. Fedorko, P. Pedowski, J. Zapletalová
Jazyk angličtina Země Spojené státy americké
Typ dokumentu multicentrická studie, časopisecké články
Grantová podpora
IGA-KZ-2021-1-15
Krajska Zdravotni
IGA UPOL_009_2023
Univerzita Palackého v Olomouci
- MeSH
- cévní mozková příhoda * diagnostické zobrazování terapie etiologie MeSH
- endovaskulární výkony * metody MeSH
- ischemická cévní mozková příhoda * diagnostické zobrazování chirurgie MeSH
- ischemie mozku * diagnostické zobrazování terapie etiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- retrospektivní studie MeSH
- senioři MeSH
- statiny * MeSH
- trombektomie metody MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
PURPOSE: Endovascular treatment (EVT) of tandem lesion (TL) in anterior circulation (AC) acute ischemic stroke (AIS) represents still a clinical challenge. We aimed to evaluate selected factors related to EVT and assess other possible predictors of good clinical outcome besides the generally known ones. METHODS: AIS patients with TL in AC treated with EVT were enrolled in the multicenter retrospective ASCENT study. A good three-month clinical outcome was scored as 0-2 points in modified Rankin Scale (mRS) and achieved recanalization using the TICI scale. Symptomatic intracerebral hemorrhage (SICH) was assessed using the SITS-MOST criteria. Logistic regression analysis was used for the assessment of possible predictors of mRS 0-2 with adjustment for potential confounders. RESULTS: In total, 300 (68.7% males, mean age 67.3 ± 10.2 years) patients with median of admission NIHSS 17 were analyzed. Recanalization (TICI 2b-3) was achieved in 290 (96.7%) patients and 176 (58.7%) had mRS 0-2. Besides the age, admission NIHSS and SICH, admission glycemia (p = 0.005, OR: 0.884) the stent patency within the first 30 days after EVT (p = 0.0003, OR: 0.219), dual antiplatelet therapy (DAPT) started within 12 h after EVT (p < 0.0001, OR: 5.006) and statin therapy started within 24 h after stenting (p < 0.0001, OR: 5.558) were found as other predictors. CONCLUSION: Admission glycemia, start of DAPT within 12 h and statin therapy within 24 h after EVT, and stent patency within the first 30 days after EVT were found as other predictors of good three-month clinical outcome in AIS patients treated with EVT for TL.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24007294
- 003
- CZ-PrNML
- 005
- 20240423155847.0
- 007
- ta
- 008
- 240412s2024 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00270-023-03649-x $2 doi
- 035 __
- $a (PubMed)38216741
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Havlíček, Roman $u Comprehensive Stroke Center, Department of Neurology, Palacký University Medical School and University Hospital Olomouc, Olomouc, Czech Republic $u Comprehensive Stroke Center, Department of Neurology, Central Military Hospital Prague, Prague, Czech Republic
- 245 10
- $a Predictors of Good Clinical Outcome After Endovascular Treatment for Acute Ischemic Stroke due to Tandem Lesion in Anterior Circulation: Results from the ASCENT Study / $c R. Havlíček, D. Šaňák, D. Černík, J. Neradová, N. Leško, Z. Gdovinová, M. Köcher, F. Cihlář, J. Malik, J. Fedorko, P. Pedowski, J. Zapletalová
- 520 9_
- $a PURPOSE: Endovascular treatment (EVT) of tandem lesion (TL) in anterior circulation (AC) acute ischemic stroke (AIS) represents still a clinical challenge. We aimed to evaluate selected factors related to EVT and assess other possible predictors of good clinical outcome besides the generally known ones. METHODS: AIS patients with TL in AC treated with EVT were enrolled in the multicenter retrospective ASCENT study. A good three-month clinical outcome was scored as 0-2 points in modified Rankin Scale (mRS) and achieved recanalization using the TICI scale. Symptomatic intracerebral hemorrhage (SICH) was assessed using the SITS-MOST criteria. Logistic regression analysis was used for the assessment of possible predictors of mRS 0-2 with adjustment for potential confounders. RESULTS: In total, 300 (68.7% males, mean age 67.3 ± 10.2 years) patients with median of admission NIHSS 17 were analyzed. Recanalization (TICI 2b-3) was achieved in 290 (96.7%) patients and 176 (58.7%) had mRS 0-2. Besides the age, admission NIHSS and SICH, admission glycemia (p = 0.005, OR: 0.884) the stent patency within the first 30 days after EVT (p = 0.0003, OR: 0.219), dual antiplatelet therapy (DAPT) started within 12 h after EVT (p < 0.0001, OR: 5.006) and statin therapy started within 24 h after stenting (p < 0.0001, OR: 5.558) were found as other predictors. CONCLUSION: Admission glycemia, start of DAPT within 12 h and statin therapy within 24 h after EVT, and stent patency within the first 30 days after EVT were found as other predictors of good three-month clinical outcome in AIS patients treated with EVT for TL.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 12
- $a ischemie mozku $x diagnostické zobrazování $x terapie $x etiologie $7 D002545
- 650 12
- $a endovaskulární výkony $x metody $7 D057510
- 650 12
- $a statiny $7 D019161
- 650 12
- $a ischemická cévní mozková příhoda $x diagnostické zobrazování $x chirurgie $7 D000083242
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 12
- $a cévní mozková příhoda $x diagnostické zobrazování $x terapie $x etiologie $7 D020521
- 650 _2
- $a trombektomie $x metody $7 D017131
- 650 _2
- $a výsledek terapie $7 D016896
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Šaňák, Daniel $u Comprehensive Stroke Center, Department of Neurology, Palacký University Medical School and University Hospital Olomouc, Olomouc, Czech Republic. daniel.sanak@centrum.cz $1 https://orcid.org/0000000154261810 $7 xx0104413
- 700 1_
- $a Černík, David $u Comprehensive Stroke Center, Department of Neurology, Masaryk Hospital, KZ a.S., Ústí Nad Labem, Czech Republic
- 700 1_
- $a Neradová, Jarmila $u Comprehensive Stroke Center, Department of Neurology, Masaryk Hospital, KZ a.S., Ústí Nad Labem, Czech Republic
- 700 1_
- $a Leško, Norbert $u Department of Neurology, P.J. Šafarik University, Faculty of Medicine and University Hospital L. Pasteur Košice, Košice, Slovakia
- 700 1_
- $a Gdovinová, Zuzana $u Department of Neurology, P.J. Šafarik University, Faculty of Medicine and University Hospital L. Pasteur Košice, Košice, Slovakia
- 700 1_
- $a Köcher, Martin $u Department of Radiology, Palacký University Medical School and University Hospital Olomouc, Olomouc, Czech Republic
- 700 1_
- $a Cihlář, Filip $u Department of Radiology, J. E. Purkinje University, Masaryk Hospital, KZ a.S., Ústí Nad Labem, Czech Republic
- 700 1_
- $a Malik, Jozef $u Department of Radiology, Central Military Hospital Prague, Prague, Czech Republic
- 700 1_
- $a Fedorko, Jakub $u Department of Radiodiagnostics and Imagine Techniques, P.J. Šafarik University, Faculty of Medicine and University Hospital L. Pasteur Košice, Košice, Slovakia
- 700 1_
- $a Pedowski, Piotr $u Department of Radiodiagnostics and Imagine Techniques, P.J. Šafarik University, Faculty of Medicine and University Hospital L. Pasteur Košice, Košice, Slovakia
- 700 1_
- $a Zapletalová, Jana $u Department of Biophysics and Statistics, Palacký University Medical School Olomouc, Olomouc, Czech Republic
- 773 0_
- $w MED00001056 $t Cardiovascular and interventional radiology $x 1432-086X $g Roč. 47, č. 2 (2024), s. 218-224
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38216741 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240412 $b ABA008
- 991 __
- $a 20240423155843 $b ABA008
- 999 __
- $a ok $b bmc $g 2081339 $s 1217061
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 47 $c 2 $d 218-224 $e 20240112 $i 1432-086X $m Cardiovascular and interventional radiology $n Cardiovasc Intervent Radiol $x MED00001056
- GRA __
- $a IGA-KZ-2021-1-15 $p Krajska Zdravotni
- GRA __
- $a IGA UPOL_009_2023 $p Univerzita Palackého v Olomouci
- LZP __
- $a Pubmed-20240412
