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Occupational Benzene Exposure and Lung Cancer Risk: A Pooled Analysis of 14 Case-Control Studies
W. Wan, S. Peters, L. Portengen, A. Olsson, J. Schüz, W. Ahrens, M. Schejbalova, P. Boffetta, T. Behrens, T. Brüning, B. Kendzia, D. Consonni, PA. Demers, E. Fabiánová, G. Fernández-Tardón, JK. Field, F. Forastiere, L. Foretova, P. Guénel, P....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu metaanalýza, časopisecké články
Grantová podpora
001
World Health Organization - International
NIH HHS - United States
CIHR - Canada
NLK
Free Medical Journals
od 1997-07-01 do Před 1 rokem
Freely Accessible Science Journals
od 1997 do Před 1 rokem
Open Access Digital Library
od 1998-01-01
- MeSH
- benzen toxicita MeSH
- karcinogeny MeSH
- lidé MeSH
- nádory plic * chemicky indukované epidemiologie MeSH
- nemoci z povolání * chemicky indukované epidemiologie MeSH
- plíce MeSH
- pracovní expozice * škodlivé účinky MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
Rationale: Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. Objectives: We aimed to examine the relationship between occupational benzene exposure and lung cancer. Methods: Subjects from 14 case-control studies across Europe and Canada were pooled. We used a quantitative job-exposure matrix to estimate benzene exposure. Logistic regression models assessed lung cancer risk across different exposure indices. We adjusted for smoking and five main occupational lung carcinogens and stratified analyses by smoking status and lung cancer subtypes. Measurements and Main Results: Analyses included 28,048 subjects (12,329 cases, 15,719 control subjects). Lung cancer odds ratios ranged from 1.12 (95% confidence interval, 1.03-1.22) to 1.32 (95% confidence interval, 1.18-1.48) (Ptrend = 0.002) for groups with the lowest and highest cumulative occupational exposures, respectively, compared with unexposed subjects. We observed an increasing trend of lung cancer with longer duration of exposure (Ptrend < 0.001) and a decreasing trend with longer time since last exposure (Ptrend = 0.02). These effects were seen for all lung cancer subtypes, regardless of smoking status, and were not influenced by specific occupational groups, exposures, or studies. Conclusions: We found consistent and robust associations between different dimensions of occupational benzene exposure and lung cancer after adjusting for smoking and main occupational lung carcinogens. These associations were observed across different subgroups, including nonsmokers. Our findings support the hypothesis that occupational benzene exposure increases the risk of developing lung cancer. Consequently, there is a need to revisit published epidemiological and molecular data on the pulmonary carcinogenicity of benzene.
Boston College Boston Massachusetts
Cancer Epidemiology Unit Department of Medical Sciences University of Turin Turin Italy
Comprehensive Pneumology Center Munich Member of the German Center for Lung Research Munich Germany
Consortium for Biomedical Research in Epidemiology and Public Health Madrid Spain
Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada
Department of Environmental Epidemiology The Nofer Institute of Occupational Medicine Lodz Poland
Department of Epidemiology Azienda Sanitaria Locale Roma E Rome Italy
Department of Medical and Surgical Sciences University of Bologna Bologna Italy
Department of Social and Preventive Medicine University of Montreal Montreal Quebec Canada
Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland
Faculty of Health Catholic University Ružomberok Slovakia
Institute and Clinic for Occupational Social and Environmental Medicine University Hospital and
Institute for Medical Informatics Biometry and Epidemiology University Hospital Essen Essen Germany
Institute for Risk Assessment Sciences Utrecht University Utrecht the Netherlands
Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
Institute of Hygiene and Epidemiology 1st Faculty of Medicine Charles University Prague Czechia
International Agency for Research on Cancer World Health Organization Lyon France
Leibniz Institute for Prevention Research and Epidemiology Bremen Germany
Masaryk Memorial Cancer Institute Brno Czechia
National Institute of Public Health Bucharest Romania
National Public Health Center Budapest Hungary
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek Utrecht the Netherlands
Occupational Cancer Research Centre Ontario Health Toronto Ontario Canada
Regional Authority of Public Health Banská Bystrica Slovakia
Stony Brook Cancer Center Stony Brook University Stony Brook New York
Citace poskytuje Crossref.org
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