-
Je něco špatně v tomto záznamu ?
High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery
K. Isand, R. Feelders, T. Brue, M. Toth, T. Deutschbein, M. Reincke, M. Kršek, A. Santos, F. Demtröder, O. Chabre, CJ. Strasburger, A. Aulinas Maso, V. Volke, AM. Pereira, R. Lohmann, I. Gich Saladich, Ercusyn Study Group , SM. Webb, J. Wass, E. Valassi
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu pozorovací studie, časopisecké články
Grantová podpora
Novartis, Ipsen, HRA, and the European Society of Endocrinology
NLK
Open Access Digital Library
od 1948-06-01
Open Access Digital Library
od 1997-07-01
PubMed
38146835
DOI
10.1093/ejendo/lvad176
Knihovny.cz E-zdroje
- MeSH
- Cushingův syndrom * komplikace epidemiologie chirurgie MeSH
- hydrokortison MeSH
- hypersekrece ACTH v hypofýze * komplikace MeSH
- lidé MeSH
- prevalence MeSH
- retrospektivní studie MeSH
- trombóza * MeSH
- žilní tromboembolie * etiologie komplikace MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
OBJECTIVE: The aim of this study was to evaluate the prevalence of venous thromboembolism (VTE) in patients included in the European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. DESIGN: A retrospective observational cohort study. METHODS: Data extraction from the registry was taken on February, 7, 2022. At the time there were 2174 patients diagnosed with Cushing's syndrome (CS) and 95 VTEs were reported in the database. RESULTS: Of 95 VTE events 70 (74%) were in pituitary-dependent CS patients, 12 (12.5%) in adrenal-dependant CS, 10 (10.5%) in ectopic CS, and 3 (3%) in CS due to other causes. Sex, 24-hour urinary free cortisol (UFC) value at diagnosis, as well as the number of operations remained statistically significant predictors of VTE. Of patients who were treated with at least one surgery, 12 (13%) VTE occurred before and 80 (87%) after the surgery. Nearly half of these VTEs occurred within six months since the operation (36; 45%). Over half of the centers that reported VTE did not routinely anticoagulate CS patients. Anticoagulation schemes varied widely. CONCLUSION: Patients with CS have an elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS. Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention that is widely adopted appears to be necessary for patients with CS.
Centro de Investigación Biomédica en Red de Enfermedades Raras Barcelona Spain
Clinical Endocrinology Charite Universitätsmedizin Campus Mitte 10117 Berlin Germany
Department of Internal Medicine and Oncology Semmelweis University 1083 Budapest Hungary
Health Care Consulting GmbH Lohmann and Birkner Health Care Consulting GmbH 13407 Berlin Germany
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc24007660
- 003
- CZ-PrNML
- 005
- 20240423160149.0
- 007
- ta
- 008
- 240412s2024 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1093/ejendo/lvad176 $2 doi
- 035 __
- $a (PubMed)38146835
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Isand, Kristina $u Institute of Biomedicine and Translational Medicine, University of Tartu, Ülikooli 18, 50090, Tartu, Estonia $1 https://orcid.org/0009000218174597
- 245 10
- $a High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery / $c K. Isand, R. Feelders, T. Brue, M. Toth, T. Deutschbein, M. Reincke, M. Kršek, A. Santos, F. Demtröder, O. Chabre, CJ. Strasburger, A. Aulinas Maso, V. Volke, AM. Pereira, R. Lohmann, I. Gich Saladich, Ercusyn Study Group , SM. Webb, J. Wass, E. Valassi
- 520 9_
- $a OBJECTIVE: The aim of this study was to evaluate the prevalence of venous thromboembolism (VTE) in patients included in the European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for VTE. DESIGN: A retrospective observational cohort study. METHODS: Data extraction from the registry was taken on February, 7, 2022. At the time there were 2174 patients diagnosed with Cushing's syndrome (CS) and 95 VTEs were reported in the database. RESULTS: Of 95 VTE events 70 (74%) were in pituitary-dependent CS patients, 12 (12.5%) in adrenal-dependant CS, 10 (10.5%) in ectopic CS, and 3 (3%) in CS due to other causes. Sex, 24-hour urinary free cortisol (UFC) value at diagnosis, as well as the number of operations remained statistically significant predictors of VTE. Of patients who were treated with at least one surgery, 12 (13%) VTE occurred before and 80 (87%) after the surgery. Nearly half of these VTEs occurred within six months since the operation (36; 45%). Over half of the centers that reported VTE did not routinely anticoagulate CS patients. Anticoagulation schemes varied widely. CONCLUSION: Patients with CS have an elevated risk of developing VTE for an extended period of time. From ERCUSYN cohort patients have higher risk for VTE if they need multiple surgeries to treat CS, are males and have high UFC values at the diagnosis of CS. Since there is no agreement on thromboprohpylaxis, a protocol for VTE prevention that is widely adopted appears to be necessary for patients with CS.
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a Cushingův syndrom $x komplikace $x epidemiologie $x chirurgie $7 D003480
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a prevalence $7 D015995
- 650 12
- $a žilní tromboembolie $x etiologie $x komplikace $7 D054556
- 650 12
- $a hypersekrece ACTH v hypofýze $x komplikace $7 D047748
- 650 12
- $a trombóza $7 D013927
- 650 _2
- $a hydrokortison $7 D006854
- 655 _2
- $a pozorovací studie $7 D064888
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Feelders, Richard $u Department of Internal Medicine, Section of Endocrinology, ENETS Center of Excellence, Erasmus MC and Erasmus Cancer Institute, 3015 Rotterdam, The Netherlands
- 700 1_
- $a Brue, Thierry $u Aix Marseille Univ, APHM, INSERM, MMG, Department of Endocrinology Hospital La Conception, MarMaRa Institute, 13305 Marseille, France $1 https://orcid.org/0000000184826691
- 700 1_
- $a Toth, Miklos $u Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, Hungary
- 700 1_
- $a Deutschbein, Timo $u Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, 97080 Würzburg, Germany
- 700 1_
- $a Reincke, Martin $u Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Ludwig-Maximilians-Universität München, 80336 Munich, Germany $1 https://orcid.org/0000000298179875
- 700 1_
- $a Kršek, Michal $u Third Department of Internal Medicine, First Faculty of Medicine, Charles University, General University Hospital, 12808 Prague, Czech Republic
- 700 1_
- $a Santos, Alicia $u IIB-Sant Pau and Department of Endocrinology, Hospital Sant Pau, Dept Medicine, UAB, and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, 08025 Barcelona, Spain $u Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), Barcelona, Spain
- 700 1_
- $a Demtröder, Frank $u Zentrum für Endokrinologie, Diabetologie, Rheumatologie Dr. Demtröder & Kollegen, 44137 Dortmund, Germany
- 700 1_
- $a Chabre, Olivier $u University Grenoble Alpes, UMR 1292 INSERM-CEA-UGA, Endocrinologie CHU Grenoble Alpes, F-38000 Grenoble, France
- 700 1_
- $a Strasburger, Christian J $u Clinical Endocrinology, Charite-Universitätsmedizin, Campus Mitte, 10117 Berlin, Germany
- 700 1_
- $a Aulinas Maso, Anna $u IIB-Sant Pau and Department of Endocrinology, Hospital Sant Pau, Dept Medicine, UAB, and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, 08025 Barcelona, Spain $u Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), Barcelona, Spain
- 700 1_
- $a Volke, Vallo $u Institute of Biomedicine and Translational Medicine, University of Tartu, Ülikooli 18, 50090, Tartu, Estonia
- 700 1_
- $a Pereira, Alberto M $u Department of Endocrinology & Metabolism, Amsterdam University Medical Center, and University of Amsterdam, 1081 Amsterdam, Netherlands
- 700 1_
- $a Lohmann, Rüdiger $u Health Care Consulting GmbH, Lohmann & Birkner Health Care Consulting GmbH, 13407 Berlin, Germany
- 700 1_
- $a Gich Saladich, Ignasi $u Department of Clinical Epidemiology and Public Health, Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), 08025 Barcelona, Spain
- 700 1_
- $a Webb, Susan M $u IIB-Sant Pau and Department of Endocrinology, Hospital Sant Pau, Dept Medicine, UAB, and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER, Unidad 747), ISCIII, 08025 Barcelona, Spain $u Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), Barcelona, Spain
- 700 1_
- $a Wass, John $u Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals, OX37LE Oxford, United Kingdom
- 700 1_
- $a Valassi, Elena $u Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), Barcelona, Spain $u Endocrinology and Nutrition Department, Germans Trias i Pujol Hospital and Research Institute, Badalona 08916, Spain $1 https://orcid.org/0000000238640105
- 710 2_
- $a Ercusyn Study Group
- 773 0_
- $w MED00009634 $t European journal of endocrinology $x 1479-683X $g Roč. 190, č. 1 (2024), s. 75-85
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38146835 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20240412 $b ABA008
- 991 __
- $a 20240423160145 $b ABA008
- 999 __
- $a ok $b bmc $g 2081568 $s 1217427
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 190 $c 1 $d 75-85 $e 20240103 $i 1479-683X $m European journal of endocrinology $n Eur J Endocrinol $x MED00009634
- GRA __
- $p Novartis, Ipsen, HRA, and the European Society of Endocrinology
- LZP __
- $a Pubmed-20240412
