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Does the Impact of COVID-19 on Patients With Systemic Sclerosis Change Over Time
E. Deibel, PE. Carreira, M. Vonk, N. Del Papa, R. Bečvář, A. Guillén-Del-Castillo, C. Campochiaro, H. Poormoghim, S. Liem, MG. Lazzaroni, A. Giollo, A. Mekinian, J. de Vries-Bouwstra, M. De Santis, A. Balbir-Gurman, C. Mihai, G. De Luca, S....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
PubMed
37667424
DOI
10.1002/acr.25226
Knihovny.cz E-zdroje
- MeSH
- COVID-19 * MeSH
- hypertenze * MeSH
- lidé MeSH
- lokalizovaná sklerodermie * MeSH
- systémová sklerodermie * komplikace diagnóza epidemiologie MeSH
- testování na COVID-19 MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: The outcome of patients with COVID-19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of patients with both SSc and COVID-19 over several waves. METHODS: Patients with both SSc and COVID-19 who were registered in the European Scleroderma Trials and Research group (EUSTAR) were collected between April 2020 and April 2021. Patients were assigned to waves 1, 2, or 3 depending on the date of their COVID-19 diagnosis. Primary endpoints were death, intensive care unit stay, or ventilatory support (severe outcome). Subgroup analyses of patients who were hospitalized or died were conducted. General and SSc-specific characteristics and treatment were compared over the waves. Descriptive statistics and multivariate logistic regression were applied. RESULTS: A total of 333 patients were included; 57 patients (17%) had a severe outcome, and 30 patients (9%) died. Compared to wave 1, significantly fewer patients with SSc suffered from severe COVID-19 in waves 2 and 3 (28.2% vs 9.8% and 12.7%; P < 0.001), fewer patients required hospitalization (46.7% vs 19.6% and 25.5%; P < 0.001) or ventilatory support (24.0% vs 8.7% and 10.9%; P = 0.001), and fewer patients died (15.7% vs 5.0% and 7.5%; P = 0.011). Patients were significantly younger, more often men, had less frequent arterial hypertension, and less SSc cardiac involvement over waves 1 to 3. Patients received significantly less medium to high doses of corticosteroids as they did SSc treatment. CONCLUSION: The outcome of patients with both SSc and COVID-19 improved significantly over time because of intrinsic and extrinsic factors.
1st Medical School Charles University Praha Czech Republic
A O U Policlinico S Marco Catania Catania Italy
ASST G Pini CTO University of Milan Milan Italy
ASST Grande Ospedale Metropolitano Niguarda Milano Italy
ASST Spedali Civili of Brescia University of Brescia Italy
Azienda Ospedaliero Universitaria di Cagliari Cagliari Italy
B Shine Rheumatology Institute and Technion Haifa Israel
Centro Hospital e Universitário de Coimbra University of Coimbra Portugal
Centro Hospitalar Universitário Lisboa Central Lisboa Portugal
Cochin Hospital Université de Paris Paris France
e Octubre University Hospital Madrid Spain
Firoozgar Hospital Tehran Iran
Ghent University Ghent University Hospital and VIB Inflammation Research Center Ghent Belgium
Hôpital Saint Antoine Paris France
Hospital Universitari de la Santa Creu 1 Sant Pau Barcelona Spain
Hospital Universitari Mútua de Terrassa Barcelona Catalonia Spain
Hospital Universitario Dr Peset Comunitat Valenciana Spain
Hospital Universitario Vall d'Hebron Barcelona Spain
IRCCS Policlinico S Matteo University Hospital Pavia Italy
IRCCS San Raffaele Hospital Milan Italy
Istanbul University Istanbul Turkey
Leiden University Medical Center Leiden The Netherlands
National and Kapodistrian University of Athens Medical School Athens Greece
Nippon Medical School Tokyo Japan
Oslo University Hospital Oslo Norway
Pomeranian Medical University in Szczecin Szczecin Poland
Radboud University Medical Center Nijmegen The Netherlands
Royal Free and University College London Medical School London UK
Sapienza University of Rome Rome Italy
Sechenov 1st Moscow State Medical University Moscow Russian Federation
Thomas Jefferson University Philadelphia Pennsylvania
Universidade Federal de Pelotas Pelotas Brazil
Università Politecnica delle Marche Polo Didattico University of Ancona Ancona Italy
Universitätsspital Basel Basel Switzerland
Université de Bordeaux Bordeaux Aquitaine France
University Clinic Schleswig Holstein Lübeck University of Lübeck Lübeck Germany
University Hospital Zurich University of Zurich Zurich Switzerland
University Medical Center Utrecht Utrecht The Netherlands
University of Bari Aldo Moro Bari Italy
University of California Los Angeles
University of Debrecen Debrecen Hungary
University of Florence Florence Italy and IRCCS San Raffaele Hospital Milan Italy
University of Genova and IRCCS Ospedale Policlinico San Martino Genova Italy
University of Genova Genova Italy
University of Marmara Istanbul Turkey
University of Medicine and Pharmacy Iuliu Hatieganu Cluj Cluj Napoca Romania
University of Messina Messina Italy
University of Padova Padova Italy
University of Verona Verona Italy
VA Nasonova Research Institute of Rheumatology Moscow Russian Federation
Citace poskytuje Crossref.org
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