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Serum autoantibodies against hexokinase 1 manifest secondary to diabetic macular edema onset

D. Šimčíková, J. Ivančinová, M. Veith, J. Dusová, V. Matušková, J. Němčanský, P. Kunčický, O. Chrapek, N. Jirásková, J. Gojda, P. Heneberg

. 2024 ; 212 (-) : 111721. [pub] 20240529

Jazyk angličtina Země Irsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24013611

AIMS: Autoantibodies against hexokinase 1 (HK1) were recently proposed to be associated with diabetic macular edema (DME). We hypothesized that anti-HK1 autoantibodies can be used as DME markers and to predict DME onset. MATERIALS AND METHODS: Serum from patients with 1) DME, 2) diabetes mellitus (DM), 3) allergies or autoimmunities, and 4) control subjects was tested for anti-HK1 and anti-hexokinase 2 (HK2) autoantibodies by immunoblotting. Patients with DM were prospectively followed for up to nine years, and the association of anti-HK1 antibodies with new-onset DME was evaluated. The vitreous humor was also tested for autoantibodies. RESULTS: Among patients with DME, 32 % were positive for anti-HK1 autoantibodies (42 % of those with underlying type 1 DM and 31 % of those with underlying type 2 DM), and 12 % were positive for anti-HK2 autoantibodies, with only partial overlap of these two groups of patients. Anti-HK1 positive were also 7 % of patients with DM, 6 % of patients with allergies and autoimmunities, and 3 % of control subjects. The latter three groups were anti-HK2 negative. Only one of seven patients with DM who were initially anti-HK1 positive developed DME. CONCLUSIONS: Anti-HK1 autoantibodies can be used as DME markers but fail to predict DME onset.

Citace poskytuje Crossref.org

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$a AIMS: Autoantibodies against hexokinase 1 (HK1) were recently proposed to be associated with diabetic macular edema (DME). We hypothesized that anti-HK1 autoantibodies can be used as DME markers and to predict DME onset. MATERIALS AND METHODS: Serum from patients with 1) DME, 2) diabetes mellitus (DM), 3) allergies or autoimmunities, and 4) control subjects was tested for anti-HK1 and anti-hexokinase 2 (HK2) autoantibodies by immunoblotting. Patients with DM were prospectively followed for up to nine years, and the association of anti-HK1 antibodies with new-onset DME was evaluated. The vitreous humor was also tested for autoantibodies. RESULTS: Among patients with DME, 32 % were positive for anti-HK1 autoantibodies (42 % of those with underlying type 1 DM and 31 % of those with underlying type 2 DM), and 12 % were positive for anti-HK2 autoantibodies, with only partial overlap of these two groups of patients. Anti-HK1 positive were also 7 % of patients with DM, 6 % of patients with allergies and autoimmunities, and 3 % of control subjects. The latter three groups were anti-HK2 negative. Only one of seven patients with DM who were initially anti-HK1 positive developed DME. CONCLUSIONS: Anti-HK1 autoantibodies can be used as DME markers but fail to predict DME onset.
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$a Ivančinová, Jana $u Third Faculty of Medicine, Charles University, Prague, Czech Republic
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$a Veith, Miroslav $u Third Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Ophthalmology, University Hospital Královské Vinohrady, Prague, Czech Republic
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$a Dusová, Jaroslava $u Department of Ophthalmology, University Hospital Hradec Králové, Hradec Králové, Czech Republic
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$a Matušková, Veronika $u Department of Ophthalmology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Ophthalmology, University Hospital Brno, Brno, Czech Republic
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$a Němčanský, Jan $u Department of Ophthalmology, University Hospital Ostrava, Ostrava, Czech Republic
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$a Kunčický, Přemysl $u Third Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Internal Medicine, University Hospital Královské Vinohrady, Prague, Czech Republic
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$a Chrapek, Oldřich $u Department of Ophthalmology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Ophthalmology, University Hospital Brno, Brno, Czech Republic
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$a Jirásková, Naďa $u Department of Ophthalmology, University Hospital Hradec Králové, Hradec Králové, Czech Republic
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$a Gojda, Jan $u Third Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Internal Medicine, University Hospital Královské Vinohrady, Prague, Czech Republic
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$a Heneberg, Petr $u Third Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address: petr.heneberg@lf3.cuni.cz
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