Serum autoantibodies against hexokinase 1 manifest secondary to diabetic macular edema onset
Language English Country Ireland Media print-electronic
Document type Journal Article
PubMed
38821414
DOI
10.1016/j.diabres.2024.111721
PII: S0168-8227(24)00631-4
Knihovny.cz E-resources
- Keywords
- Autoimmunity, Disease marker, Disease prediction, Glycolysis, Tissue damage, Vitreous fluid,
- MeSH
- Autoantibodies * blood immunology MeSH
- Biomarkers blood MeSH
- Diabetes Mellitus, Type 1 immunology complications blood MeSH
- Diabetes Mellitus, Type 2 immunology complications blood MeSH
- Diabetic Retinopathy * immunology blood MeSH
- Adult MeSH
- Hexokinase * immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Macular Edema * immunology blood MeSH
- Prospective Studies MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Autoantibodies * MeSH
- Biomarkers MeSH
- Hexokinase * MeSH
- HK1 protein, human MeSH Browser
AIMS: Autoantibodies against hexokinase 1 (HK1) were recently proposed to be associated with diabetic macular edema (DME). We hypothesized that anti-HK1 autoantibodies can be used as DME markers and to predict DME onset. MATERIALS AND METHODS: Serum from patients with 1) DME, 2) diabetes mellitus (DM), 3) allergies or autoimmunities, and 4) control subjects was tested for anti-HK1 and anti-hexokinase 2 (HK2) autoantibodies by immunoblotting. Patients with DM were prospectively followed for up to nine years, and the association of anti-HK1 antibodies with new-onset DME was evaluated. The vitreous humor was also tested for autoantibodies. RESULTS: Among patients with DME, 32 % were positive for anti-HK1 autoantibodies (42 % of those with underlying type 1 DM and 31 % of those with underlying type 2 DM), and 12 % were positive for anti-HK2 autoantibodies, with only partial overlap of these two groups of patients. Anti-HK1 positive were also 7 % of patients with DM, 6 % of patients with allergies and autoimmunities, and 3 % of control subjects. The latter three groups were anti-HK2 negative. Only one of seven patients with DM who were initially anti-HK1 positive developed DME. CONCLUSIONS: Anti-HK1 autoantibodies can be used as DME markers but fail to predict DME onset.
3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Ophthalmology University Hospital Hradec Králové Hradec Králové Czech Republic
Department of Ophthalmology University Hospital Ostrava Ostrava Czech Republic
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