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Genetic alteration profiling in middle-aged women acutely exposed during the mechanical processing of dental nanocomposites

A. Rossnerova, I. Chvojkova, F. Elzeinova, D. Pelclova, P. Klusackova, V. Zdimal, L. Ondrackova, P. Bradna, A. Roubickova, Z. Simova, P. Rossner

. 2024 ; 108 (-) : 104462. [pub] 20240506

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24013646

Nanoparticles (NPs) have become an important part of everyday life, including their application in dentistry. Aside from their undoubted benefits, questions regarding their risk to human health, and/or genome have arisen. However, studies concerning cytogenetic effects are completely absent. A group of women acutely exposed to an aerosol released during dental nanocomposite grinding was sampled before and after the work. Exposure monitoring including nano (PM0.1) and respirable (PM4) fractions was performed. Whole-chromosome painting for autosomes #1, #4, and gonosome X was applied to estimate the pattern of cytogenetic damage including structural and numerical alterations. The results show stable genomic frequency of translocations (FG/100), in contrast to a significant 37.8% (p<0.05) increase of numerical aberrations caused by monosomies (p<0.05), but not trisomies. Monosomies were mostly observed for chromosome X. In conclusion, exposure to nanocomposites in stomatology may lead to an increase in numerical aberrations which can be dangerous for dividing cells.

Citace poskytuje Crossref.org

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$a Rossnerova, Andrea $u Department of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Czech Republic. Electronic address: andrea.rossnerova@iem.cas.cz
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$a Nanoparticles (NPs) have become an important part of everyday life, including their application in dentistry. Aside from their undoubted benefits, questions regarding their risk to human health, and/or genome have arisen. However, studies concerning cytogenetic effects are completely absent. A group of women acutely exposed to an aerosol released during dental nanocomposite grinding was sampled before and after the work. Exposure monitoring including nano (PM0.1) and respirable (PM4) fractions was performed. Whole-chromosome painting for autosomes #1, #4, and gonosome X was applied to estimate the pattern of cytogenetic damage including structural and numerical alterations. The results show stable genomic frequency of translocations (FG/100), in contrast to a significant 37.8% (p<0.05) increase of numerical aberrations caused by monosomies (p<0.05), but not trisomies. Monosomies were mostly observed for chromosome X. In conclusion, exposure to nanocomposites in stomatology may lead to an increase in numerical aberrations which can be dangerous for dividing cells.
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$a Chvojkova, Irena $u Department of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Czech Republic
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$a Elzeinova, Fatima $u Department of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Czech Republic
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$a Pelclova, Daniela $u Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
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$a Klusackova, Pavlina $u Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
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$a Zdimal, Vladimir $u Department of Aerosol Chemistry and Physics, Institute of Chemical Process Fundamentals CAS, Czech Republic
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$a Ondrackova, Lucie $u Department of Aerosol Chemistry and Physics, Institute of Chemical Process Fundamentals CAS, Czech Republic
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$a Bradna, Pavel $u Institute of Dental Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
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$a Roubickova, Adela $u Institute of Dental Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic
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$a Simova, Zuzana $u Department of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Czech Republic
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