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European consensus-based interdisciplinary guideline for diagnosis, treatment and prevention of actinic keratoses, epithelial UV-induced dysplasia and field cancerization on behalf of European Association of Dermato-Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes)
L. Kandolf, K. Peris, J. Malvehy, K. Mosterd, MV. Heppt, MC. Fargnoli, C. Berking, P. Arenberger, M. Bylaite-Bučinskiene, V. Del Marmol, T. Dirschka, B. Dreno, AM. Forsea, CA. Harwood, A. Hauschild, IM. Heerfordt, R. Kauffman, N....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, směrnice pro lékařskou praxi
PubMed
38451047
DOI
10.1111/jdv.19897
Knihovny.cz E-zdroje
- MeSH
- aktinická keratóza * diagnóza terapie prevence a kontrola MeSH
- dermatologie normy metody MeSH
- konsensus MeSH
- lidé MeSH
- nádory kůže * prevence a kontrola diagnóza terapie etiologie MeSH
- spinocelulární karcinom prevence a kontrola diagnóza terapie etiologie MeSH
- ultrafialové záření škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- směrnice pro lékařskou praxi MeSH
- Geografické názvy
- Evropa MeSH
A collaboration of multidisciplinary experts from the European Association of Dermato-Oncology, the European Dermatology Forum, the European Academy of Dermatology and Venereology, and the European Union of Medical Specialists was formed to develop European recommendations on AK diagnosis and treatment, based on current literature and expert consensus. This guideline addresses the epidemiology, diagnostics, risk stratification and treatments in immunocompetent as well as immunosuppressed patients. Actinic keratoses (AK) are potential precursors of cutaneous squamous cell carcinoma (cSCC) and display typical histopathologic and immunohistochemical features of this malignancy in an early stage. They can develop into cSSC in situ and become invasive in a low percentage of cases. AK is the most frequent neoplasia in white populations, frequently occurring within a cancerous field induced by ultraviolet radiation. Since it cannot be predicted, which lesion will progress to cSCC and when treatment is usually recommended. The diagnosis of AK and field cancerization is made by clinical examination. Dermatoscopy, confocal microscopy, optical coherence tomography or line-field confocal-OCT can help in the differential diagnosis of AK and other skin neoplasms. A biopsy is indicated in clinically and/or dermatoscopically suspicious and/or treatment-refractory lesions. The choice of treatment depends on patients' and lesion characteristics. For single non-hyperkeratotic lesions, the treatment can be started upon patient's request with destructive treatments or topical treatments. For multiple lesions, field cancerization treatment is advised with topical treatments and photodynamic therapy. Preventive measures such as sun protection, self-examination and repeated field cancerization treatments of previously affected skin areas in high-risk patients are advised.
1st Department of Dermatology Aristotle University Thessaloniki Greece
Centre for Dermatooncology Department of Dermatology Eberhard Karls University Tuebingen Germany
CentroDerm Clinic Wuppertal Germany
Comprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg Erlangen Germany
Department of Dermatology University Hospital Erasme Université Libre de Bruxelles Brussels Belgium
Department of Dermatology University Hospital Kiel Germany
Department of Dermatology University of Modena and Reggio Emilia Modena Italy
Dermatologia Università Cattolica del Sacro Cuore Rome Italy
Faculty of Health University Witten Herdecke Witten Germany
GROW School for Oncology and Reproduction Maastricht University Maastricht The Netherlands
Skin Cancer Center Azienda Unità Sanitaria Locale IRCCS di Reggio Emilia Reggio Emilia Italy
Skin Cancer Center Department of Dermatology Ruhr University Bochum Bochum Germany
Citace poskytuje Crossref.org
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- $a A collaboration of multidisciplinary experts from the European Association of Dermato-Oncology, the European Dermatology Forum, the European Academy of Dermatology and Venereology, and the European Union of Medical Specialists was formed to develop European recommendations on AK diagnosis and treatment, based on current literature and expert consensus. This guideline addresses the epidemiology, diagnostics, risk stratification and treatments in immunocompetent as well as immunosuppressed patients. Actinic keratoses (AK) are potential precursors of cutaneous squamous cell carcinoma (cSCC) and display typical histopathologic and immunohistochemical features of this malignancy in an early stage. They can develop into cSSC in situ and become invasive in a low percentage of cases. AK is the most frequent neoplasia in white populations, frequently occurring within a cancerous field induced by ultraviolet radiation. Since it cannot be predicted, which lesion will progress to cSCC and when treatment is usually recommended. The diagnosis of AK and field cancerization is made by clinical examination. Dermatoscopy, confocal microscopy, optical coherence tomography or line-field confocal-OCT can help in the differential diagnosis of AK and other skin neoplasms. A biopsy is indicated in clinically and/or dermatoscopically suspicious and/or treatment-refractory lesions. The choice of treatment depends on patients' and lesion characteristics. For single non-hyperkeratotic lesions, the treatment can be started upon patient's request with destructive treatments or topical treatments. For multiple lesions, field cancerization treatment is advised with topical treatments and photodynamic therapy. Preventive measures such as sun protection, self-examination and repeated field cancerization treatments of previously affected skin areas in high-risk patients are advised.
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