Circadian Dexras1 in rats: Development, location and responsiveness to light
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- Klíčová slova
- Dexras1, light, rat, suprachiasmatic nucleus,
- MeSH
- biologické hodiny fyziologie MeSH
- cirkadiánní proteiny Period metabolismus MeSH
- cirkadiánní rytmus fyziologie MeSH
- messenger RNA metabolismus MeSH
- nucleus suprachiasmaticus fyziologie MeSH
- potkani Wistar MeSH
- Ras proteiny genetika MeSH
- světelná stimulace metody MeSH
- světlo MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cirkadiánní proteiny Period MeSH
- messenger RNA MeSH
- Ras proteiny MeSH
- Rasd1 protein, rat MeSH Prohlížeč
Dexras1 has been shown to exhibit clock-dependent rhythm in mice suprachiasmatic nucleus (SCN), and its genetic deletion modulates circadian responses to photic and nonphotic cues. We show that the rhythmic expression of Dexras1 mRNA and protein in rat SCN already oscillates with low amplitude at postnatal day 3 and can be detected as early as embryonic day 20. In contrast, its expression in peripheral tissues is not rhythmic in adult rats either. The Dexras1 protein is expressed predominantly in the dorsomedial part of the SCN and the light pulse has only a limited effect on its expression. Our data provide the descriptive basis for speculation about the Dexras1 involvement in the rat circadian physiology.
Citace poskytuje Crossref.org
