Circadian Dexras1 in rats: Development, location and responsiveness to light
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Dexras1, light, rat, suprachiasmatic nucleus,
- MeSH
- Biological Clocks physiology MeSH
- Period Circadian Proteins metabolism MeSH
- Circadian Rhythm physiology MeSH
- RNA, Messenger metabolism MeSH
- Suprachiasmatic Nucleus physiology MeSH
- Rats, Wistar MeSH
- ras Proteins genetics MeSH
- Photic Stimulation methods MeSH
- Light MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Period Circadian Proteins MeSH
- RNA, Messenger MeSH
- ras Proteins MeSH
- Rasd1 protein, rat MeSH Browser
Dexras1 has been shown to exhibit clock-dependent rhythm in mice suprachiasmatic nucleus (SCN), and its genetic deletion modulates circadian responses to photic and nonphotic cues. We show that the rhythmic expression of Dexras1 mRNA and protein in rat SCN already oscillates with low amplitude at postnatal day 3 and can be detected as early as embryonic day 20. In contrast, its expression in peripheral tissues is not rhythmic in adult rats either. The Dexras1 protein is expressed predominantly in the dorsomedial part of the SCN and the light pulse has only a limited effect on its expression. Our data provide the descriptive basis for speculation about the Dexras1 involvement in the rat circadian physiology.
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