BACKGROUND: Since many acutely admitted older adults display signs of dehydration, treatment using balanced crystalloids is an important part of medical care. Additionally, many of these patients suffer from chronic malnutrition. We speculated that the early addition of glucose might ameliorate the hospital-related drop of caloric intake and modify their catabolic status. METHODS: We included patients 78 years and older, admitted acutely for non-traumatic illnesses. The patients were randomized into either receiving balanced crystalloid (PlasmaLyte; group P) or balanced crystalloid enriched with 100 g of glucose per liter (group G). The information about fluid balance and levels of minerals were collected longitudinally. RESULTS: In the G group, a significantly higher proportion of patients developed signs of refeeding syndrome, i.e., drops in phosphates, potassium and/or magnesium when compared to group P (83.3 vs. 16.7%, p < 0.01). The drop in phosphate levels was the most pronounced. The urinalysis showed no differences in the levels of these minerals in the urine, suggesting their uptake into the cells. There were no differences in the in-hospital mortality or in the 1-year mortality. CONCLUSION: The short-term administration of balanced crystalloids with glucose induced an anabolic shift of electrolytes in acutely admitted older adults.

3rd Department of Internal Medicine Metabolism and Gerontology University Hospital Hradec Kralove 500 05 Hradec Kralove Czech Republic

Department of Military Internal Medicine and Military Hygiene Military Faculty of Medicine University of Defence 500 01 Hradec Kralove Czech Republic

Faculty of Medicine in Hradec Kralove Charles University 500 03 Hradec Kralove Czech Republic

Geriatric Center Pardubice Hospital 532 03 Pardubice Czech Republic

Oroboros Instruments 6020 Innsbruck Austria

Citace poskytuje Crossref.org