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Mpox across countries from Central and Eastern Europe - 2022 outbreak

I. Ianache, A. Skrzat-Klapaczynska, D. Jilich, L. Fleischhans, I. Gmizic, J. Ranin, A. Papadopoulos, K. Protopapas, V. Mulabdic, B. Lakatos, EL. Nagy, J. Begovac, T. Holban, DY. Sevgi, A. Cicic, N. Yancheva, L. Sojak, N. Rukhadze, J. Kowalska, C....

. 2024 ; 59 (-) : 102719. [pub] 20240402

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24014094

BACKGROUND: The aim of the study was to assess socio-demographical characteristics, clinical presentation, and outcomes in patients diagnosed with mpox. METHODS: A survey on patients diagnosed with mpox was performed in 14 countries from Central and Eastern Europe. Data was compared according to HIV status and country of origin (EU vs. non-EU). Mpox diagnosis was confirmed by RT-PCR from oropharyngeal swabs, skin lesions, and other body fluids. RESULTS: Out of 154 patients confirmed with mpox in 2022, 99.3% were males, with a median age (years) of 35 (IQR 30-39), 90.2% MSM and 48.7% PLWH. Compared to HIV-negative subjects, PLWH had more frequent high-risk behaviours:chemsex (p = 0.015), group sex (p = 0.027), and a history of sexually transmitted infections (STIs) (p = 0.004). Persons from EU were more often PLWH (p = 0.042), MSM (p < 0.0001), had multiple sexual partners (p = 0.025), practiced chemsex (p = 0.008) or group-sex (p = 0.005) and had more often history of STIs (p < 0.0001). The median CD4 cell count/mL at mpox diagnosis was 713 (IQR 486-996) and 73.5% had undetectable HIV VL. The commonest clinical features were fever (108 cases), lymphadenopathy (78), and vesiculo-pustular rash: penile (76), perianal (48), limbs (67). Fifty-one (31%) persons were hospitalized due to complications or epidemiological reasons. Three patients received tecovirimat or cidofovir. The outcome was favorable for all patients, including 4 with severe forms. CONCLUSIONS: Mpox was diagnosed predominantly in young MSM, with high-risk behaviors and history of STIs. Effective contact tracing and vaccination are important strategic pillars to control mpox outbreaks.

Citace poskytuje Crossref.org

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$a BACKGROUND: The aim of the study was to assess socio-demographical characteristics, clinical presentation, and outcomes in patients diagnosed with mpox. METHODS: A survey on patients diagnosed with mpox was performed in 14 countries from Central and Eastern Europe. Data was compared according to HIV status and country of origin (EU vs. non-EU). Mpox diagnosis was confirmed by RT-PCR from oropharyngeal swabs, skin lesions, and other body fluids. RESULTS: Out of 154 patients confirmed with mpox in 2022, 99.3% were males, with a median age (years) of 35 (IQR 30-39), 90.2% MSM and 48.7% PLWH. Compared to HIV-negative subjects, PLWH had more frequent high-risk behaviours:chemsex (p = 0.015), group sex (p = 0.027), and a history of sexually transmitted infections (STIs) (p = 0.004). Persons from EU were more often PLWH (p = 0.042), MSM (p < 0.0001), had multiple sexual partners (p = 0.025), practiced chemsex (p = 0.008) or group-sex (p = 0.005) and had more often history of STIs (p < 0.0001). The median CD4 cell count/mL at mpox diagnosis was 713 (IQR 486-996) and 73.5% had undetectable HIV VL. The commonest clinical features were fever (108 cases), lymphadenopathy (78), and vesiculo-pustular rash: penile (76), perianal (48), limbs (67). Fifty-one (31%) persons were hospitalized due to complications or epidemiological reasons. Three patients received tecovirimat or cidofovir. The outcome was favorable for all patients, including 4 with severe forms. CONCLUSIONS: Mpox was diagnosed predominantly in young MSM, with high-risk behaviors and history of STIs. Effective contact tracing and vaccination are important strategic pillars to control mpox outbreaks.
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$a Jilich, David $u Department of Infectious Diseases, 1st Faculty of Medicine, Charles University in Prague and Faculty Hospital Bulovka, Czech Republic
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$a Fleischhans, Lukas $u Department of Infectious Diseases, 1st Faculty of Medicine, Charles University in Prague and Faculty Hospital Bulovka, Czech Republic
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$a Gmizic, Ivana $u Clinic for Infectious and Tropical Diseases, University Clinical Centre of Serbia, Belgrade, Serbia
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$a Ranin, Jovan $u Clinic for Infectious and Tropical Diseases, University Clinical Centre of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Serbia
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$a Papadopoulos, Antonios $u 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Greece
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$a Protopapas, Konstantinos $u 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Greece
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$a Mulabdic, Velida $u Clinic for Infectious Diseases, Clinical Center University of Sarajevo, Bosnia and Herzegovina
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$a Lakatos, Botond $u National Institute of Hematology and Infectious Diseases, National Center of HIV, Budapest, Hungary
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$a Nagy, Eva Livia $u National Institute of Hematology and Infectious Diseases, National Center of HIV, Budapest, Hungary
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$a Begovac, Josip $u University Hospital for Infectious Diseases, Zagreb, Croatia
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$a Holban, Tiberiu $u Nicolae Testemitanu Medical and Pharmaceutical State University, Chișinău, Republic of Moldova
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$a Sevgi, Dilek Yildiz $u University of Health Sciences, Turkey
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$a Cicic, Alma $u Centre for Communicable Diseases Control and Prevention Institute for Public Health, Podgorica, Montenegro
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$a Yancheva, Nina $u Medical University of Sofia, Specialized Hospital for Infectious and Parasitic Diseases, Sofia, Bulgaria
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$a Sojak, Lubomir $u The University Hospital Bratislava, Slovakia
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$a Rukhadze, Nino $u Infectious Diseases, AIDS and Clinical Immunology Research Center, Tbilisi, Georgia
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$a Kowalska, Justyna $u Department of Adults' Infectious Diseases, Hospital for Infectious Diseases, Medical University of Warsaw, Poland
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$a Oprea, Cristiana $u Victor Babes Hospital for Infectious and Tropical Diseases, Bucharest, Romania; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Electronic address: cristiana_oprea@umfcd.ro
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