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Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer's disease
HM. Albadrani, P. Chauhan, S. Ashique, MA. Babu, D. Iqbal, AG. Almutary, MM. Abomughaid, M. Kamal, AC. Paiva-Santos, M. Alsaweed, M. Hamed, P. Sachdeva, S. Dewanjee, SK. Jha, S. Ojha, P. Slama, NK. Jha
Jazyk angličtina Země Francie
Typ dokumentu časopisecké články, přehledy
- MeSH
- Alzheimerova nemoc * farmakoterapie dietoterapie metabolismus MeSH
- amyloidní beta-protein metabolismus MeSH
- biologická dostupnost MeSH
- dieta MeSH
- lidé MeSH
- nanočástice chemie MeSH
- neuroprotektivní látky terapeutické užití farmakologie MeSH
- polyfenoly * farmakologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with memory loss and a progressive decline in cognitive activity. The two major pathophysiological factors responsible for AD are amyloid plaques (comprising amyloid-beta aggregates) and neurofibrillary tangles (consisting of hyperphosphorylated tau protein). Polyphenols, a class of naturally occurring compounds, are immensely beneficial for the treatment or management of various disorders and illnesses. Naturally occurring sources of polyphenols include plants and plant-based foods, such as fruits, herbs, tea, vegetables, coffee, red wine, and dark chocolate. Polyphenols have unique properties, such as being the major source of anti-oxidants and possessing anti-aging and anti-cancerous properties. Currently, dietary polyphenols have become a potential therapeutic approach for the management of AD, depending on various research findings. Dietary polyphenols can be an effective strategy to tackle multifactorial events that occur with AD. For instance, naturally occurring polyphenols have been reported to exhibit neuroprotection by modulating the Aβ biogenesis pathway in AD. Many nanoformulations have been established to enhance the bioavailability of polyphenols, with nanonization being the most promising. This review comprehensively provides mechanistic insights into the neuroprotective potential of dietary polyphenols in treating AD. It also reviews the usability of dietary polyphenol as nanoformulation for AD treatment.
Centre of Research Impact and Outcome Chitkara University Rajpura 140401 Punjab India
Department of Pathology Faculty of Medicine Umm Al Qura University Makkah 21955 Saudi Arabia
Department of Pharmaceutical Sciences Maharshi Dayanad University Rohtak Haryana 124001 India
Department of Zoology Kalindi College University of Delhi 110008 India
Institute of Pharmaceutical Research GLA University Mathura India
School of Bioengineering and Biosciences Lovely Professional University Phagwara 144411 India
Citace poskytuje Crossref.org
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- $a Albadrani, Hind Muteb $u Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province 34212, Saudi Arabia
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- $a Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with memory loss and a progressive decline in cognitive activity. The two major pathophysiological factors responsible for AD are amyloid plaques (comprising amyloid-beta aggregates) and neurofibrillary tangles (consisting of hyperphosphorylated tau protein). Polyphenols, a class of naturally occurring compounds, are immensely beneficial for the treatment or management of various disorders and illnesses. Naturally occurring sources of polyphenols include plants and plant-based foods, such as fruits, herbs, tea, vegetables, coffee, red wine, and dark chocolate. Polyphenols have unique properties, such as being the major source of anti-oxidants and possessing anti-aging and anti-cancerous properties. Currently, dietary polyphenols have become a potential therapeutic approach for the management of AD, depending on various research findings. Dietary polyphenols can be an effective strategy to tackle multifactorial events that occur with AD. For instance, naturally occurring polyphenols have been reported to exhibit neuroprotection by modulating the Aβ biogenesis pathway in AD. Many nanoformulations have been established to enhance the bioavailability of polyphenols, with nanonization being the most promising. This review comprehensively provides mechanistic insights into the neuroprotective potential of dietary polyphenols in treating AD. It also reviews the usability of dietary polyphenol as nanoformulation for AD treatment.
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