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Pharmacokinetic-based Dosing Individualization of Mycophenolate Mofetil in Solid Organ Transplanted Patients
S. Merdita, P. Ryšánek, J. M. Hartinger, O. Slanař, M. Šíma
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, přehledy
Grantová podpora
VFN00064165
Ministerstvo Zdravotnictví Ceské Republiky
NLK
Directory of Open Access Journals
od 2012
Medline Complete (EBSCOhost)
od 2012-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2013
- MeSH
- imunosupresiva * farmakokinetika aplikace a dávkování MeSH
- individualizovaná medicína MeSH
- kyselina mykofenolová * farmakokinetika aplikace a dávkování MeSH
- lidé MeSH
- rejekce štěpu prevence a kontrola MeSH
- transplantace orgánů * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Mycophenolate mofetil (MMF) is an immunosuppressant drug approved for prophylaxis of transplant rejection in patients undergoing solid organ transplantation and is further employed in management of various autoimmune disorders. MMF exhibits notable pharmacokinetic inter- and intraindividual variability necessitating tailored therapeutic approaches to achieve optimal therapeutic outcomes while mitigating risks of adverse effects. The objective of this review was to summarize factors that influence the pharmacokinetics of MMF and its active metabolite mycophenolic acid in order to deduce recommendations for personalized treatment strategies. Presumed predictors were analysed in relation to each of the four pharmacokinetic phases, providing tools and targets for MMF dosing optimization amenable to clinical implementation.
Citace poskytuje Crossref.org
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