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Neuronal maturation and axon regeneration: unfixing circuitry to enable repair
BJ. Hilton, JM. Griffin, JW. Fawcett, F. Bradke
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
NLK
ProQuest Central
od 2000-10-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2000-10-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-10-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2000-10-01 do Před 1 rokem
- MeSH
- axony * fyziologie MeSH
- lidé MeSH
- neurogeneze * fyziologie MeSH
- neurony fyziologie MeSH
- regenerace nervu * fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Mammalian neurons lose the ability to regenerate their central nervous system axons as they mature during embryonic or early postnatal development. Neuronal maturation requires a transformation from a situation in which neuronal components grow and assemble to one in which these components are fixed and involved in the machinery for effective information transmission and computation. To regenerate after injury, neurons need to overcome this fixed state to reactivate their growth programme. A variety of intracellular processes involved in initiating or sustaining neuronal maturation, including the regulation of gene expression, cytoskeletal restructuring and shifts in intracellular trafficking, have been shown to prevent axon regeneration. Understanding these processes will contribute to the identification of targets to promote repair after injury or disease.
Citace poskytuje Crossref.org
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- $a Mammalian neurons lose the ability to regenerate their central nervous system axons as they mature during embryonic or early postnatal development. Neuronal maturation requires a transformation from a situation in which neuronal components grow and assemble to one in which these components are fixed and involved in the machinery for effective information transmission and computation. To regenerate after injury, neurons need to overcome this fixed state to reactivate their growth programme. A variety of intracellular processes involved in initiating or sustaining neuronal maturation, including the regulation of gene expression, cytoskeletal restructuring and shifts in intracellular trafficking, have been shown to prevent axon regeneration. Understanding these processes will contribute to the identification of targets to promote repair after injury or disease.
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