Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women

J. Vitku, A. Varausova, T. Skodova, L. Kolatorova, M. Vosatkova, J. Vcelak, J. Vrbikova, M. Simkova, M. Svojtkova

. 2024 ; 25 (17) : . [pub] 20240907

Language English Country Switzerland

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc24018966

Grant support
Institute of Endocrinology EÚ, 00023761. Ministry of Health of the Czech Republic - DRO

Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) are androgen excess disorders requiring the determination of classic androgen levels for diagnosis. 11-oxygenated androgens have high androgenic potential, yet their clinical value in those disorders is not clear. Additionally, the role of endocrine disruptors (EDs), particularly in IH, remains understudied. We analyzed 25 steroids and 18 EDs in plasma samples from women with IH, PCOS, and controls using LC-MS/MS. Cytokine levels and metabolic parameters were assessed. Comparisons included non-obese women with PCOS (n = 10), women with IH (n = 12) and controls (n = 20), and non-obese versus obese women with PCOS (n = 9). Higher levels of 11-oxygenated androgens were observed in women with PCOS compared to those with IH, but not controls. Conversely, 11-oxygenated androgen levels were lower in women with IH compared to controls. Cytokine levels did not differ between women with IH and controls. Bisphenol A (BPA) levels were higher in obese women with PCOS compared to non-obese women with PCOS. Bisphenol S occurrence was higher in women with PCOS (90%) compared to controls (65%) and IH (50%). Significant correlations were found between androgens (11-ketotestosterone, androstenedione, testosterone) and insulin and HOMA-IR, as well as between immunomodulatory 7-oxygenated metabolites of DHEA and nine interleukins. Our data confirms that PCOS is a multiendocrine gland disorder. Higher BPA levels in obese women might exacerbate metabolic abnormalities. IH was not confirmed as an inflammatory state, and no differences in BPA levels suggest BPA does not play a role in IH pathogenesis.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24018966
003      
CZ-PrNML
005      
20250318090336.0
007      
ta
008      
241015s2024 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms25179691 $2 doi
035    __
$a (PubMed)39273637
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Vitku, Jana $u Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic $1 https://orcid.org/0000000308057602
245    14
$a The Role of 11-Oxygenated Androgens and Endocrine Disruptors in Androgen Excess Disorders in Women / $c J. Vitku, A. Varausova, T. Skodova, L. Kolatorova, M. Vosatkova, J. Vcelak, J. Vrbikova, M. Simkova, M. Svojtkova
520    9_
$a Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) are androgen excess disorders requiring the determination of classic androgen levels for diagnosis. 11-oxygenated androgens have high androgenic potential, yet their clinical value in those disorders is not clear. Additionally, the role of endocrine disruptors (EDs), particularly in IH, remains understudied. We analyzed 25 steroids and 18 EDs in plasma samples from women with IH, PCOS, and controls using LC-MS/MS. Cytokine levels and metabolic parameters were assessed. Comparisons included non-obese women with PCOS (n = 10), women with IH (n = 12) and controls (n = 20), and non-obese versus obese women with PCOS (n = 9). Higher levels of 11-oxygenated androgens were observed in women with PCOS compared to those with IH, but not controls. Conversely, 11-oxygenated androgen levels were lower in women with IH compared to controls. Cytokine levels did not differ between women with IH and controls. Bisphenol A (BPA) levels were higher in obese women with PCOS compared to non-obese women with PCOS. Bisphenol S occurrence was higher in women with PCOS (90%) compared to controls (65%) and IH (50%). Significant correlations were found between androgens (11-ketotestosterone, androstenedione, testosterone) and insulin and HOMA-IR, as well as between immunomodulatory 7-oxygenated metabolites of DHEA and nine interleukins. Our data confirms that PCOS is a multiendocrine gland disorder. Higher BPA levels in obese women might exacerbate metabolic abnormalities. IH was not confirmed as an inflammatory state, and no differences in BPA levels suggest BPA does not play a role in IH pathogenesis.
650    _2
$a lidé $7 D006801
650    _2
$a ženské pohlaví $7 D005260
650    12
$a syndrom polycystických ovarií $x krev $x metabolismus $7 D011085
650    12
$a androgeny $x krev $x metabolismus $7 D000728
650    12
$a endokrinní disruptory $x krev $7 D052244
650    _2
$a dospělí $7 D000328
650    12
$a hirzutismus $x krev $x etiologie $x chemicky indukované $7 D006628
650    _2
$a obezita $x krev $x metabolismus $7 D009765
650    _2
$a cytokiny $x krev $x metabolismus $7 D016207
650    _2
$a tandemová hmotnostní spektrometrie $7 D053719
650    _2
$a benzhydrylové sloučeniny $x krev $7 D001559
650    _2
$a hyperandrogenismus $x krev $7 D017588
650    _2
$a fenoly $7 D010636
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Varausová, Anežka $u Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic $1 https://orcid.org/0009000240658619 $7 xx0330058
700    1_
$a Skodova, Tereza $u Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic $1 https://orcid.org/0000000319386946
700    1_
$a Kolatorova, Lucie $u Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic $1 https://orcid.org/0000000282064598 $7 xx0140729
700    1_
$a Vosatkova, Michala $u Department of Clinical Biochemistry, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic
700    1_
$a Vcelak, Josef $u Department of Molecular Endocrinology, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic $1 https://orcid.org/0000000265460580 $7 xx0107261
700    1_
$a Vrbikova, Jana $u Department of Clinical Endocrinology, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic
700    1_
$a Simkova, Marketa $u Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic $1 https://orcid.org/0000000204179867
700    1_
$a Svojtkova, Michaela $u Department of Steroids and Proteofactors, Institute of Endocrinology, Narodni 8, 116 94 Prague, Czech Republic $1 https://orcid.org/0000000247811447 $7 xx0080454
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 25, č. 17 (2024)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39273637 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20241015 $b ABA008
991    __
$a 20250318090333 $b ABA008
999    __
$a ok $b bmc $g 2201668 $s 1230939
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 25 $c 17 $e 20240907 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a Institute of Endocrinology EÚ, 00023761. $p Ministry of Health of the Czech Republic - DRO
LZP    __
$a Pubmed-20241015

Find record

Citation metrics

Archiving options