• Je něco špatně v tomto záznamu ?

Poly(ε-Caprolactone)-Based Composites Modified With Polymer-Grafted Magnetic Nanoparticles and L-Ascorbic Acid for Bone Tissue Engineering

A. Hlukhaniuk, M. Świętek, V. Patsula, J. Hodan, O. Janoušková, L. Bystrianský, A. Brož, M. Malić, B. Zasońska, W. Tokarz, L. Bačáková, D. Horák

. 2024 ; 112 (9) : e35480. [pub] -

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24019047

Grantová podpora
European Union
2022 Akademie Věd České Republiky
Grantová Agentura České Republiky
20-07015S Czech Science Foundation
LX22NPO5102 National Institute for Cancer Research

The aim of this study was to develop multifunctional magnetic poly(ε-caprolactone) (PCL) mats with antibacterial properties for bone tissue engineering and osteosarcoma prevention. To provide good dispersion of magnetic iron oxide nanoparticles (IONs), they were first grafted with PCL using a novel three-step approach. Then, a series of PCL-based mats containing a fixed amount of ION@PCL particles and an increasing content of ascorbic acid (AA) was prepared by electrospinning. AA is known for increasing osteoblast activity and suppressing osteosarcoma cells. Composites were characterized in terms of morphology, mechanical properties, hydrolytic stability, antibacterial performance, and biocompatibility. AA affected both the fiber diameter and the mechanical properties of the nanocomposites. All produced mats were nontoxic to rat bone marrow-derived mesenchymal cells; however, a composite with 5 wt.% of AA suppressed the initial proliferation of SAOS-2 osteoblast-like cells. Moreover, AA improved antibacterial properties against Staphylococcus aureus and Escherichia coli compared to PCL. Overall, these magnetic composites, reported for the very first time, can be used as scaffolds for both tissue regeneration and osteosarcoma prevention.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24019047
003      
CZ-PrNML
005      
20241024111145.0
007      
ta
008      
241015s2024 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/jbm.b.35480 $2 doi
035    __
$a (PubMed)39223717
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Hlukhaniuk, Anna $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic $u Faculty of Science, Charles University, Prague, Czech Republic
245    10
$a Poly(ε-Caprolactone)-Based Composites Modified With Polymer-Grafted Magnetic Nanoparticles and L-Ascorbic Acid for Bone Tissue Engineering / $c A. Hlukhaniuk, M. Świętek, V. Patsula, J. Hodan, O. Janoušková, L. Bystrianský, A. Brož, M. Malić, B. Zasońska, W. Tokarz, L. Bačáková, D. Horák
520    9_
$a The aim of this study was to develop multifunctional magnetic poly(ε-caprolactone) (PCL) mats with antibacterial properties for bone tissue engineering and osteosarcoma prevention. To provide good dispersion of magnetic iron oxide nanoparticles (IONs), they were first grafted with PCL using a novel three-step approach. Then, a series of PCL-based mats containing a fixed amount of ION@PCL particles and an increasing content of ascorbic acid (AA) was prepared by electrospinning. AA is known for increasing osteoblast activity and suppressing osteosarcoma cells. Composites were characterized in terms of morphology, mechanical properties, hydrolytic stability, antibacterial performance, and biocompatibility. AA affected both the fiber diameter and the mechanical properties of the nanocomposites. All produced mats were nontoxic to rat bone marrow-derived mesenchymal cells; however, a composite with 5 wt.% of AA suppressed the initial proliferation of SAOS-2 osteoblast-like cells. Moreover, AA improved antibacterial properties against Staphylococcus aureus and Escherichia coli compared to PCL. Overall, these magnetic composites, reported for the very first time, can be used as scaffolds for both tissue regeneration and osteosarcoma prevention.
650    12
$a polyestery $x chemie $7 D011091
650    12
$a tkáňové inženýrství $7 D023822
650    12
$a kyselina askorbová $x chemie $x farmakologie $7 D001205
650    _2
$a lidé $7 D006801
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a zvířata $7 D000818
650    12
$a Staphylococcus aureus $x účinky léků $x růst a vývoj $7 D013211
650    _2
$a Escherichia coli $x účinky léků $7 D004926
650    _2
$a antibakteriální látky $x chemie $x farmakologie $7 D000900
650    _2
$a magnetické nanočástice $x chemie $7 D058185
650    _2
$a osteoblasty $x metabolismus $x cytologie $7 D010006
650    _2
$a nádorové buněčné linie $7 D045744
650    _2
$a osteosarkom $x patologie $7 D012516
650    _2
$a kosti a kostní tkáň $7 D001842
650    _2
$a nanokompozity $x chemie $7 D053761
650    _2
$a tkáňové podpůrné struktury $x chemie $7 D054457
650    _2
$a testování materiálů $7 D008422
655    _2
$a časopisecké články $7 D016428
700    1_
$a Świętek, Małgorzata $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic $1 https://orcid.org/0000000278005130
700    1_
$a Patsula, Vitalii $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Hodan, Jiří $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Janoušková, Olga $u Faculty of Science, Jan Evangelista Purkyně University in Ústí nad Labem, Ústí nad Labem, Czech Republic
700    1_
$a Bystrianský, Lukáš $u Faculty of Science, Jan Evangelista Purkyně University in Ústí nad Labem, Ústí nad Labem, Czech Republic
700    1_
$a Brož, Antonín $u Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Malić, Marina $u Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Zasońska, Beata $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Tokarz, Waldemar $u Faculty of Physics and Applied Computer Science, AGH University of Krakow, Krakow, Poland
700    1_
$a Bačáková, Lucie $u Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Horák, Daniel $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Prague, Czech Republic $1 https://orcid.org/0000000269079701 $7 xx0076519
773    0_
$w MED00007497 $t Journal of biomedical materials research. Part B, Applied biomaterials $x 1552-4981 $g Roč. 112, č. 9 (2024), s. e35480
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39223717 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20241015 $b ABA008
991    __
$a 20241024111139 $b ABA008
999    __
$a ok $b bmc $g 2201706 $s 1231020
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 112 $c 9 $d e35480 $e - $i 1552-4981 $m Journal of biomedical materials research. Part B, Applied biomaterials $n J Biomed Mater Res B Appl Biomater $x MED00007497
GRA    __
$p European Union
GRA    __
$a 2022 $p Akademie Věd České Republiky
GRA    __
$p Grantová Agentura České Republiky
GRA    __
$a 20-07015S $p Czech Science Foundation
GRA    __
$a LX22NPO5102 $p National Institute for Cancer Research
LZP    __
$a Pubmed-20241015

Najít záznam

Citační ukazatele

Možnosti archivace