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Early diagnosis of solitary functioning kidney: comparing the prognosis of kidney agenesis and multicystic dysplastic kidney
H. Flogelova, K. Bouchalova, O. Smakal, J. Halek, K. Langova, K. Cizkova
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, srovnávací studie
NLK
ProQuest Central
od 1996-08-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 1996-08-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 1996-08-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1996-08-01 do Před 1 rokem
Family Health Database (ProQuest)
od 1996-08-01 do Před 1 rokem
- MeSH
- časná diagnóza * MeSH
- dítě MeSH
- hodnoty glomerulární filtrace * MeSH
- hypertenze diagnóza etiologie epidemiologie patofyziologie MeSH
- kojenec MeSH
- ledviny * abnormality patofyziologie diagnostické zobrazování MeSH
- lidé MeSH
- multicystické dysplastické ledviny * diagnóza komplikace patofyziologie MeSH
- následné studie MeSH
- nemoci ledvin vrozené MeSH
- novorozenec MeSH
- novorozenecký screening metody MeSH
- předškolní dítě MeSH
- prognóza MeSH
- proteinurie * etiologie diagnóza MeSH
- solitární ledvina * komplikace diagnóza patofyziologie MeSH
- vrozené vady diagnóza diagnostické zobrazování MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
BACKGROUND: Individuals with congenital solitary functioning kidney (SFK) are at an increased risk of kidney damage. According to some studies, the risk is higher in unilateral kidney agenesis (UKA) than in unilateral multicystic dysplastic kidney (UMCDK). We hypothesized that with early detection of children with UKA and UMCDK, there would be no difference in the presence of hypertension, proteinuria, and reduced glomerular filtration rate (GFR) between UKA and UMCDK. METHODS: Based on a long-term follow-up protocol, we evaluated a cohort of 160 children followed from birth for SFK (84 with UKA and 76 with UMCDK) detected by prenatal or routine neonatal ultrasound screening. Hypertension, proteinuria, and reduced GFR were monitored as markers of kidney damage. We compared the characteristics and outcomes of the subgroups of children with UKA and UMCDK. RESULTS: GFR was reduced in 42 (26.2%) children, of whom 41 showed only mild reduction. Hypertension and proteinuria were found in 22 (13.8%) and 14 (8.8%) children, respectively. Combined kidney damage was present in 57 (35.6%) children. The UMCDK and UKA subgroups differed in GFR at final examination, with UMCDK patients being significantly more likely to have normal GFR compared to UKA patients (82% vs. 67%; p = 0.039). CONCLUSIONS: One third of the children showed signs of SFK damage, albeit mild. Patients with UKA had reduced GFR significantly more often than those with UMCDK, but did not differ in the rates of hyperfiltration injury or congenital anomalies of the kidneys and urinary tract (CAKUT) in SFK.
Department of Neonatology University Hospital Olomouc Olomouc Czech Republic
Department of Urology University Hospital Olomouc Olomouc Czech Republic
Citace poskytuje Crossref.org
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- $a Flogelova, Hana $u Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Zdravotniku 248/7, 779 00, Olomouc, Czech Republic. Hana.Flogelova@seznam.cz $1 https://orcid.org/0000000329955735 $7 xx0096386
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- $a BACKGROUND: Individuals with congenital solitary functioning kidney (SFK) are at an increased risk of kidney damage. According to some studies, the risk is higher in unilateral kidney agenesis (UKA) than in unilateral multicystic dysplastic kidney (UMCDK). We hypothesized that with early detection of children with UKA and UMCDK, there would be no difference in the presence of hypertension, proteinuria, and reduced glomerular filtration rate (GFR) between UKA and UMCDK. METHODS: Based on a long-term follow-up protocol, we evaluated a cohort of 160 children followed from birth for SFK (84 with UKA and 76 with UMCDK) detected by prenatal or routine neonatal ultrasound screening. Hypertension, proteinuria, and reduced GFR were monitored as markers of kidney damage. We compared the characteristics and outcomes of the subgroups of children with UKA and UMCDK. RESULTS: GFR was reduced in 42 (26.2%) children, of whom 41 showed only mild reduction. Hypertension and proteinuria were found in 22 (13.8%) and 14 (8.8%) children, respectively. Combined kidney damage was present in 57 (35.6%) children. The UMCDK and UKA subgroups differed in GFR at final examination, with UMCDK patients being significantly more likely to have normal GFR compared to UKA patients (82% vs. 67%; p = 0.039). CONCLUSIONS: One third of the children showed signs of SFK damage, albeit mild. Patients with UKA had reduced GFR significantly more often than those with UMCDK, but did not differ in the rates of hyperfiltration injury or congenital anomalies of the kidneys and urinary tract (CAKUT) in SFK.
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