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Early diagnosis of solitary functioning kidney: comparing the prognosis of kidney agenesis and multicystic dysplastic kidney
H. Flogelova, K. Bouchalova, O. Smakal, J. Halek, K. Langova, K. Cizkova
Language English Country Germany
Document type Journal Article, Comparative Study
NLK
ProQuest Central
from 1996-08-01 to 1 year ago
Medline Complete (EBSCOhost)
from 1996-08-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 1996-08-01 to 1 year ago
Health & Medicine (ProQuest)
from 1996-08-01 to 1 year ago
Family Health Database (ProQuest)
from 1996-08-01 to 1 year ago
- MeSH
- Early Diagnosis * MeSH
- Child MeSH
- Glomerular Filtration Rate * MeSH
- Hypertension diagnosis etiology epidemiology physiopathology MeSH
- Infant MeSH
- Kidney * abnormalities physiopathology diagnostic imaging MeSH
- Humans MeSH
- Multicystic Dysplastic Kidney * diagnosis complications physiopathology MeSH
- Follow-Up Studies MeSH
- Kidney Diseases congenital MeSH
- Infant, Newborn MeSH
- Neonatal Screening methods MeSH
- Child, Preschool MeSH
- Prognosis MeSH
- Proteinuria * etiology diagnosis MeSH
- Solitary Kidney * complications diagnosis physiopathology MeSH
- Congenital Abnormalities diagnosis diagnostic imaging MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
BACKGROUND: Individuals with congenital solitary functioning kidney (SFK) are at an increased risk of kidney damage. According to some studies, the risk is higher in unilateral kidney agenesis (UKA) than in unilateral multicystic dysplastic kidney (UMCDK). We hypothesized that with early detection of children with UKA and UMCDK, there would be no difference in the presence of hypertension, proteinuria, and reduced glomerular filtration rate (GFR) between UKA and UMCDK. METHODS: Based on a long-term follow-up protocol, we evaluated a cohort of 160 children followed from birth for SFK (84 with UKA and 76 with UMCDK) detected by prenatal or routine neonatal ultrasound screening. Hypertension, proteinuria, and reduced GFR were monitored as markers of kidney damage. We compared the characteristics and outcomes of the subgroups of children with UKA and UMCDK. RESULTS: GFR was reduced in 42 (26.2%) children, of whom 41 showed only mild reduction. Hypertension and proteinuria were found in 22 (13.8%) and 14 (8.8%) children, respectively. Combined kidney damage was present in 57 (35.6%) children. The UMCDK and UKA subgroups differed in GFR at final examination, with UMCDK patients being significantly more likely to have normal GFR compared to UKA patients (82% vs. 67%; p = 0.039). CONCLUSIONS: One third of the children showed signs of SFK damage, albeit mild. Patients with UKA had reduced GFR significantly more often than those with UMCDK, but did not differ in the rates of hyperfiltration injury or congenital anomalies of the kidneys and urinary tract (CAKUT) in SFK.
Department of Neonatology University Hospital Olomouc Olomouc Czech Republic
Department of Urology University Hospital Olomouc Olomouc Czech Republic
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- $a BACKGROUND: Individuals with congenital solitary functioning kidney (SFK) are at an increased risk of kidney damage. According to some studies, the risk is higher in unilateral kidney agenesis (UKA) than in unilateral multicystic dysplastic kidney (UMCDK). We hypothesized that with early detection of children with UKA and UMCDK, there would be no difference in the presence of hypertension, proteinuria, and reduced glomerular filtration rate (GFR) between UKA and UMCDK. METHODS: Based on a long-term follow-up protocol, we evaluated a cohort of 160 children followed from birth for SFK (84 with UKA and 76 with UMCDK) detected by prenatal or routine neonatal ultrasound screening. Hypertension, proteinuria, and reduced GFR were monitored as markers of kidney damage. We compared the characteristics and outcomes of the subgroups of children with UKA and UMCDK. RESULTS: GFR was reduced in 42 (26.2%) children, of whom 41 showed only mild reduction. Hypertension and proteinuria were found in 22 (13.8%) and 14 (8.8%) children, respectively. Combined kidney damage was present in 57 (35.6%) children. The UMCDK and UKA subgroups differed in GFR at final examination, with UMCDK patients being significantly more likely to have normal GFR compared to UKA patients (82% vs. 67%; p = 0.039). CONCLUSIONS: One third of the children showed signs of SFK damage, albeit mild. Patients with UKA had reduced GFR significantly more often than those with UMCDK, but did not differ in the rates of hyperfiltration injury or congenital anomalies of the kidneys and urinary tract (CAKUT) in SFK.
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