Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

APOL1 polymorphisms are not influencing acute coronary syndrome risk in Czech males

JA. Hubacek, V. Adamkova, V. Lanska, V. Stanek, J. Mrazkova, M. Gebauerova, J. Kettner, J. Kautzner, J. Pitha

. 2024 ; 12 (8) : e2449. [pub] -

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24019425

Grantová podpora
00023001 Ministerstvo Zdravotnictví Ceské Republiky

BACKGROUND: The highest mortality and morbidity worldwide is associated with atherosclerotic cardiovascular disease (ASCVD), which has in background both environmental and genetic risk factors. Apolipoprotein L1 (APOL1) variability influences the risk of ASCVD in Africans, but little is known about the APOL1 and ASCVD in other ethnic groups. METHODS: To investigate the role of APOL1 and ASCVD, we have genotyped four (rs13056427, rs136147, rs10854688 and rs9610473) APOL1 polymorphisms in a group of 1541 male patients with acute coronary syndrome (ACS) and 1338 male controls. RESULTS: Individual APOL1 polymorphisms were not associated with traditional CVD risk factors such as smoking, hypertension or diabetes prevalence, with BMI values or plasma lipid levels. Neither individual polymorphisms nor haplotypes were associated with an increased risk of ACS nor did they predict total or cardiovascular mortality over the 10.2 ± 3.9 years of follow-up. CONCLUSIONS: We conclude that APOL1 genetic variability has no major effect on risk of ACS in Caucasians.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24019425
003      
CZ-PrNML
005      
20241024110724.0
007      
ta
008      
241015s2024 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/mgg3.2449 $2 doi
035    __
$a (PubMed)39171649
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Hubacek, Jaroslav A $u Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic $u 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic $1 https://orcid.org/0000000165371353
245    10
$a APOL1 polymorphisms are not influencing acute coronary syndrome risk in Czech males / $c JA. Hubacek, V. Adamkova, V. Lanska, V. Stanek, J. Mrazkova, M. Gebauerova, J. Kettner, J. Kautzner, J. Pitha
520    9_
$a BACKGROUND: The highest mortality and morbidity worldwide is associated with atherosclerotic cardiovascular disease (ASCVD), which has in background both environmental and genetic risk factors. Apolipoprotein L1 (APOL1) variability influences the risk of ASCVD in Africans, but little is known about the APOL1 and ASCVD in other ethnic groups. METHODS: To investigate the role of APOL1 and ASCVD, we have genotyped four (rs13056427, rs136147, rs10854688 and rs9610473) APOL1 polymorphisms in a group of 1541 male patients with acute coronary syndrome (ACS) and 1338 male controls. RESULTS: Individual APOL1 polymorphisms were not associated with traditional CVD risk factors such as smoking, hypertension or diabetes prevalence, with BMI values or plasma lipid levels. Neither individual polymorphisms nor haplotypes were associated with an increased risk of ACS nor did they predict total or cardiovascular mortality over the 10.2 ± 3.9 years of follow-up. CONCLUSIONS: We conclude that APOL1 genetic variability has no major effect on risk of ACS in Caucasians.
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    12
$a apolipoprotein L1 $x genetika $7 D000075944
650    12
$a akutní koronární syndrom $x genetika $7 D054058
650    _2
$a lidé středního věku $7 D008875
650    _2
$a senioři $7 D000368
650    _2
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a apolipoproteiny $x genetika $7 D001053
650    _2
$a lipoproteiny HDL $x genetika $7 D008075
650    _2
$a rizikové faktory $7 D012307
650    _2
$a studie případů a kontrol $7 D016022
650    _2
$a genetická predispozice k nemoci $7 D020022
650    _2
$a běloši $x genetika $7 D044465
650    _2
$a haplotypy $7 D006239
651    _2
$a Česká republika $7 D018153
655    _2
$a časopisecké články $7 D016428
700    1_
$a Adamkova, Vera $u Preventive Cardiology Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Lanska, Vera $u Department of Informatics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Stanek, Vladimir $u Cardiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Mrazkova, Jolana $u Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Gebauerova, Marie $u Cardiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Kettner, Jiri $u Cardiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Kautzner, Josef $u Cardiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Pitha, Jan $u Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
773    0_
$w MED00205675 $t Molecular genetics & genomic medicine $x 2324-9269 $g Roč. 12, č. 8 (2024), s. e2449
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39171649 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20241015 $b ABA008
991    __
$a 20241024110718 $b ABA008
999    __
$a ok $b bmc $g 2201953 $s 1231398
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 12 $c 8 $d e2449 $e - $i 2324-9269 $m Molecular genetics & genomic medicine $n Mol Genet Genomic Med $x MED00205675
GRA    __
$a 00023001 $p Ministerstvo Zdravotnictví Ceské Republiky
LZP    __
$a Pubmed-20241015

Najít záznam

Citační ukazatele

Možnosti archivace