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Exploring caspase functions in mouse models
E. Svandova, B. Vesela, E. Janeckova, Y. Chai, E. Matalova
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, přehledy
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2000-02-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
- MeSH
- apoptóza MeSH
- kaspasy * metabolismus genetika MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- myši knockoutované * MeSH
- myši MeSH
- zánět enzymologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Caspases are enzymes with protease activity. Despite being known for more than three decades, caspase investigation still yields surprising and fascinating information. Initially associated with cell death and inflammation, their functions have gradually been revealed to extend beyond, targeting pathways such as cell proliferation, migration, and differentiation. These processes are also associated with disease mechanisms, positioning caspases as potential targets for numerous pathologies including inflammatory, neurological, metabolic, or oncological conditions. While in vitro studies play a crucial role in elucidating molecular pathways, they lack the context of the body's complexity. Therefore, laboratory animals are an indispensable part of successfully understanding and applying caspase networks. This paper aims to summarize and discuss recent knowledge, understanding, and challenges in caspase knock-out mice.
Center for Craniofacial Molecular Biology University of Southern California Los Angeles USA
Department of Physiology University of Veterinary Sciences Brno Czech Republic
Citace poskytuje Crossref.org
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