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Seroprevalence of adeno-associated virus types 1, 2, 3, 4, 5, 6, 8, and 9 in a Basque cohort of healthy donors

M. Navarro-Oliveros, A. Vidaurrazaga, G. Soares Guerra, D. Castellana, N. Embade, O. Millet, UM. Marigorta, NGA. Abrescia

. 2024 ; 14 (1) : 15941. [pub] 20240710

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24019765

Grantová podpora
RTI2018-095700-B-I00, Agencia Estatal de Investigación
RTI2018-095700-B-I00, Agencia Estatal de Investigación
CEX2021-001136-S Agencia Estatal de Investigación
CEX2021-001136-S Agencia Estatal de Investigación
LCF/BQ/DI19/11730041 'la Caixa' Foundation
LCF/BQ/DI19/11730041 'la Caixa' Foundation
bg21 and bg23 Basque Elkartek programme
bg21 and bg23 Basque Elkartek programme

Adeno-associated viruses (AAVs) are promising gene therapy vectors, but challenges arise when treating patients with preexisting neutralizing antibodies. Worldwide seroprevalence studies provide snapshots of existing immunity in diverse populations. Owing to the uniqueness of the Basque socio-geographical landscape, we investigated the seroprevalence of eight AAV serotypes in residents of the Basque Country. We found the highest seroprevalence of AAV3, and the lowest seroprevalence of AAV9. Additionally, less than 50% of the Basque population has neutralizing antibodies against AAV4, AAV6, and AAV9. Our findings provide insight into AAV infections in the Basque region, public health, and the development of AAV-based therapeutics.

Citace poskytuje Crossref.org

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