• Je něco špatně v tomto záznamu ?

Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies

Z. Tao, Z. Chyra, J. Kotulová, P. Celichowski, J. Mihályová, S. Charvátová, R. Hájek

. 2024 ; 14 (1) : 213. [pub] 20241203

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc25003105

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment paradigms for hematological malignancies. However, more than half of these patients cannot achieve sustainable tumor control, partially due to the inadequate potency of CAR-T cells in eradicating tumor cells. T cells are crucial components of the anti-tumor immune response, and multiple intrinsic T-cell features significantly influence the outcomes of CAR-T cell therapy. Herein, we review progressing research on T-cell characteristics that impact the effectiveness of CAR-T cells, including T-cell exhaustion, memory subsets, senescence, regulatory T-cells, the CD4+ to CD8+ T-cell ratio, metabolism, and the T-cell receptor repertoire. With comprehensive insight into the biological processes underlying successful CAR-T cell therapy, we will further refine the applications of these novel therapeutic modalities, and enhance their efficacy and safety for patients.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25003105
003      
CZ-PrNML
005      
20250206104037.0
007      
ta
008      
250121s2024 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41408-024-01193-6 $2 doi
035    __
$a (PubMed)39627220
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Tao, Zhongfei $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $1 https://orcid.org/0009000384236300
245    10
$a Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies / $c Z. Tao, Z. Chyra, J. Kotulová, P. Celichowski, J. Mihályová, S. Charvátová, R. Hájek
520    9_
$a Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment paradigms for hematological malignancies. However, more than half of these patients cannot achieve sustainable tumor control, partially due to the inadequate potency of CAR-T cells in eradicating tumor cells. T cells are crucial components of the anti-tumor immune response, and multiple intrinsic T-cell features significantly influence the outcomes of CAR-T cell therapy. Herein, we review progressing research on T-cell characteristics that impact the effectiveness of CAR-T cells, including T-cell exhaustion, memory subsets, senescence, regulatory T-cells, the CD4+ to CD8+ T-cell ratio, metabolism, and the T-cell receptor repertoire. With comprehensive insight into the biological processes underlying successful CAR-T cell therapy, we will further refine the applications of these novel therapeutic modalities, and enhance their efficacy and safety for patients.
650    _2
$a lidé $7 D006801
650    12
$a hematologické nádory $x terapie $x imunologie $7 D019337
650    12
$a imunoterapie adoptivní $x metody $7 D016219
650    12
$a chimerické antigenní receptory $x imunologie $7 D000076962
650    _2
$a T-lymfocyty $x imunologie $7 D013601
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Chyra, Zuzana $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
700    1_
$a Kotulová, Jana $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $1 https://orcid.org/0000000263213340
700    1_
$a Celichowski, Piotr $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
700    1_
$a Mihályová, Jana $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
700    1_
$a Charvátová, Sandra $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
700    1_
$a Hájek, Roman $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic. roman.hajek@fno.cz $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic. roman.hajek@fno.cz $1 https://orcid.org/0000000169556267 $7 nlk20000083645
773    0_
$w MED00187996 $t Blood cancer journal $x 2044-5385 $g Roč. 14, č. 1 (2024), s. 213
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39627220 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250121 $b ABA008
991    __
$a 20250206104033 $b ABA008
999    __
$a ok $b bmc $g 2263079 $s 1239112
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 14 $c 1 $d 213 $e 20241203 $i 2044-5385 $m Blood cancer journal $n Blood Cancer J $x MED00187996
LZP    __
$a Pubmed-20250121

Najít záznam

Citační ukazatele

Možnosti archivace