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Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies

Z. Tao, Z. Chyra, J. Kotulová, P. Celichowski, J. Mihályová, S. Charvátová, R. Hájek

. 2024 ; 14 (1) : 213. [pub] 20241203

Language English Country United States

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc25003105

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment paradigms for hematological malignancies. However, more than half of these patients cannot achieve sustainable tumor control, partially due to the inadequate potency of CAR-T cells in eradicating tumor cells. T cells are crucial components of the anti-tumor immune response, and multiple intrinsic T-cell features significantly influence the outcomes of CAR-T cell therapy. Herein, we review progressing research on T-cell characteristics that impact the effectiveness of CAR-T cells, including T-cell exhaustion, memory subsets, senescence, regulatory T-cells, the CD4+ to CD8+ T-cell ratio, metabolism, and the T-cell receptor repertoire. With comprehensive insight into the biological processes underlying successful CAR-T cell therapy, we will further refine the applications of these novel therapeutic modalities, and enhance their efficacy and safety for patients.

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$a Kotulová, Jana $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $1 https://orcid.org/0000000263213340
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