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Sex dependence of postoperative pulmonary complications - A post hoc unmatched and matched analysis of LAS VEGAS
TD. Vermeulen, L. Hol, P. Swart, M. Hiesmayr, GH. Mills, C. Putensen, W. Schmid, A. Serpa Neto, P. Severgnini, MF. Vidal Melo, H. Wrigge, MW. Hollmann, M. Gama de Abreu, MJ. Schultz, SN. Hemmes, DM. van Meenen, LAS VEGAS Collaborators group,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, pozorovací studie, multicentrická studie
NLK
ProQuest Central
od 2003-01-01 do Před 2 měsíci
Nursing & Allied Health Database (ProQuest)
od 2003-01-01 do Před 2 měsíci
Health & Medicine (ProQuest)
od 2003-01-01 do Před 2 měsíci
- MeSH
- celková anestezie * škodlivé účinky MeSH
- délka pobytu * statistika a číselné údaje MeSH
- dospělí MeSH
- incidence MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- plicní nemoci * epidemiologie etiologie MeSH
- pooperační komplikace * epidemiologie etiologie MeSH
- rizikové faktory MeSH
- senioři MeSH
- sexuální faktory MeSH
- tendenční skóre MeSH
- umělé dýchání statistika a číselné údaje MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
STUDY OBJECTIVE: Male sex has inconsistently been associated with the development of postoperative pulmonary complications (PPCs). These studies were different in size, design, population and preoperative risk. We reanalysed the database of 'Local ASsessment of Ventilatory management during General Anaesthesia for Surgery study' (LAS VEGAS) to evaluate differences between females and males with respect to PPCs. DESIGN, SETTING AND PATIENTS: Post hoc unmatched and matched analysis of LAS VEGAS, an international observational study in patients undergoing intraoperative ventilation under general anaesthesia for surgery in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs in the first 5 postoperative days. Individual PPCs, hospital length of stay and mortality were secondary endpoints. Propensity score matching was used to create a similar cohort regarding type of surgery and epidemiological factors with a known association with development of PPCs. MAIN RESULTS: The unmatched cohort consisted of 9697 patients; 5342 (55.1%) females and 4355 (44.9%) males. The matched cohort consisted of 6154 patients; 3077 (50.0%) females and 3077 (50.0%) males. The incidence in PPCs was neither significant between females and males in the unmatched cohort (10.0 vs 10.7%; odds ratio (OR) 0.93 [0.81-1.06]; P = 0.255), nor in the matched cohort (10.5 vs 10.0%; OR 1.05 [0.89-1.25]; P = 0.556). New invasive ventilation occurred less often in females in the unmatched cohort. Hospital length of stay and mortality were similar between females and males in both cohorts. CONCLUSIONS: In this conveniently-sized worldwide cohort of patients receiving intraoperative ventilation under general anaesthesia for surgery, the PPC incidence was not significantly different between sexes. REGISTRATION: LAS VEGAS was registered at clinicaltrial.gov (study identifier NCT01601223).
Cleveland Clinic Department of Cardiothoracic Anaesthesia 9500 Euclid Avenue OH 44195 Cleveland USA
Cleveland Clinic Department of Outcomes Research 9500 Euclid Avenue OH 44195 Cleveland USA
Columbia University Department of Anesthesiology 622 W 168th St NY 10032 New York USA
Martin Luther University of Halle Wittenberg Medical Faculty 06108 Halle Germany
Citace poskytuje Crossref.org
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- $a STUDY OBJECTIVE: Male sex has inconsistently been associated with the development of postoperative pulmonary complications (PPCs). These studies were different in size, design, population and preoperative risk. We reanalysed the database of 'Local ASsessment of Ventilatory management during General Anaesthesia for Surgery study' (LAS VEGAS) to evaluate differences between females and males with respect to PPCs. DESIGN, SETTING AND PATIENTS: Post hoc unmatched and matched analysis of LAS VEGAS, an international observational study in patients undergoing intraoperative ventilation under general anaesthesia for surgery in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs in the first 5 postoperative days. Individual PPCs, hospital length of stay and mortality were secondary endpoints. Propensity score matching was used to create a similar cohort regarding type of surgery and epidemiological factors with a known association with development of PPCs. MAIN RESULTS: The unmatched cohort consisted of 9697 patients; 5342 (55.1%) females and 4355 (44.9%) males. The matched cohort consisted of 6154 patients; 3077 (50.0%) females and 3077 (50.0%) males. The incidence in PPCs was neither significant between females and males in the unmatched cohort (10.0 vs 10.7%; odds ratio (OR) 0.93 [0.81-1.06]; P = 0.255), nor in the matched cohort (10.5 vs 10.0%; OR 1.05 [0.89-1.25]; P = 0.556). New invasive ventilation occurred less often in females in the unmatched cohort. Hospital length of stay and mortality were similar between females and males in both cohorts. CONCLUSIONS: In this conveniently-sized worldwide cohort of patients receiving intraoperative ventilation under general anaesthesia for surgery, the PPC incidence was not significantly different between sexes. REGISTRATION: LAS VEGAS was registered at clinicaltrial.gov (study identifier NCT01601223).
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